Lipid Rafts and Caveolae
Lipid Rafts and Caveolae

Author: Christopher J. Fielding

Publisher: John Wiley & Sons

Published: 2006-12-13

Total Pages: 294

ISBN-13: 3527607501

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This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.

Lipid Domains
Lipid Domains

Author:

Publisher: Academic Press

Published: 2015-06-08

Total Pages: 393

ISBN-13: 0128033274

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Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information

Membrane Dynamics and Domains
Membrane Dynamics and Domains

Author: Peter J. Quinn

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 502

ISBN-13: 1475758065

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The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.

Membrane Microdomain Signaling
Membrane Microdomain Signaling

Author: Mark P. Mattson

Publisher: Springer Science & Business Media

Published: 2007-10-27

Total Pages: 219

ISBN-13: 159259803X

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Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Lipid Rafts
Lipid Rafts

Author: Dan Sillence

Publisher: Nova Science Publishers

Published: 2014

Total Pages: 0

ISBN-13: 9781629489612

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For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells is not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organisation of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer -- 'lipid raft' hypothesis. Lipid rafts are compelling since they provide spontaneous organisation for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains? Do they rely on specific interactions and how do they change in response to cell signalling processes? Do they help in the understanding of cell signalling and immune function and how may they be disrupted in disease processes such as neurodegeneration?

B Cell Receptor Signaling
B Cell Receptor Signaling

Author: Tomohiro Kurosaki

Publisher: Springer

Published: 2015-12-26

Total Pages: 233

ISBN-13: 3319261339

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This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Lipid Rafts
Lipid Rafts

Author: Thomas Nils

Publisher:

Published: 2018

Total Pages: 0

ISBN-13: 9781536136241

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Lipid rafts are nanometer-sized subdomains of the plasma membrane containing higher concentrations of cholesterol, phosphatidylinositols, and sphingolipids. In Lipid Rafts: Properties and Role in Signaling, the authors summarize their observations that receptor preassembly is required for biological function; the interaction between receptor chains requires both the presence of Jak1 and their co-nanolocalization within lipid raft; a sequence-supported structural analysis of Janus kinases that suggests a significant influence of phospholipids on Janus kinase function; and critical observations made by others. The authors go on to discuss the way in which some studies have pointed out the relative contribution of microdomain lipid raft abnormalities to the pathophysiology of cardiovascular disease or cancer, and examples of substances known to affect lateral membrane organization in cells are discussed as potential therapeutics. A mini-review is included which summarizes the present data behind the relevance of lipid raft membrane domains in neuronal survival and death, with a particular emphasis in age-related neurodegenerative diseases. Furthermore, the emerging importance of the lipid matrix in alpha-synuclein protein configurations in synucleopathies will also be discussed. Lastly, the authors attempt to understand the molecular background of low-solubility of neuronal membrane to non-ionic detergent and find that phosphatidylserine prepared from brain showed insolubility to Triton X-100 at 4℃. Additionally, it was found that some lipid-derived molecules increased the solubility of neuronal DRM to non-ionic detergents.