Ligand Design in Medicinal Inorganic Chemistry

Ligand Design in Medicinal Inorganic Chemistry

Author: Tim Storr

Publisher: John Wiley & Sons

Published: 2014-06-12

Total Pages: 650

ISBN-13: 1118697898

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Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.


Medicinal Inorganic Chemistry

Medicinal Inorganic Chemistry

Author: Jonathan L. Sessler

Publisher:

Published: 2005

Total Pages: 480

ISBN-13:

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This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.


Advances in Metallodrugs

Advances in Metallodrugs

Author: Shahid Ul Islam

Publisher: John Wiley & Sons

Published: 2020-07-08

Total Pages: 432

ISBN-13: 1119640423

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This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.


Uses of Inorganic Chemistry in Medicine

Uses of Inorganic Chemistry in Medicine

Author: Nicholas Farrell

Publisher: Royal Society of Chemistry

Published: 1999

Total Pages: 180

ISBN-13: 9780854044443

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This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will be an invaluable asset for many in the discipline.


Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

Author: Kenneth Kam-Wing Lo

Publisher: Academic Press

Published: 2016-12-30

Total Pages: 408

ISBN-13: 012803887X

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Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. - Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas - Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells - Foscuses on the fundamentals and their potential therapeutic and diagnostic applications - Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents


Medicinal Inorganic Chemistry

Medicinal Inorganic Chemistry

Author: Ajay Kumar Goswami

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2024-12-16

Total Pages: 153

ISBN-13: 3111426734

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The book is novel in many aspects in the field of Inorganic Medicinal Chemistry which is a less explored area. The salient feature include Theoretical drug designing using PASS, ADMET and Docking studies for organic ligands Hydroxytriazenes and their cobalt complexes. Alternative systems of medicine like Ayurveda , Zuotai and Chinese system. Role of metal complexes in medicine has been extensively reviewed and presented. Extremely useful book for students of Pharma. Medicinal chemistry and doctoral students of chemistry as well as allied branches.


Metals in Medicine

Metals in Medicine

Author: James C. Dabrowiak

Publisher: John Wiley & Sons

Published: 2017-05-02

Total Pages: 751

ISBN-13: 1119191343

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Working from basic chemical principles, Metals in Medicine, 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer's, Wilson's and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine, 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.


Fluorescence Microscopy in Life Sciences

Fluorescence Microscopy in Life Sciences

Author: Juan Carlos Stockert

Publisher: Bentham Science Publishers

Published: 2017-12-15

Total Pages: 751

ISBN-13: 1681085186

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Fluorescence Microscopy is a precise and widely employed technique in many research and clinical areas nowadays. Fluorescence Microscopy In Life Sciences introduces readers to both the fundamentals and the applications of fluorescence microscopy in the biomedical field as well as biological research. Readers will learn about physical and chemical mechanisms giving rise to the phenomenon of luminescence and fluorescence in a comprehensive way. Also, the different processes that modulate fluorescence efficiency and fluorescence features are explored and explained.


Ruthenium Chemistry

Ruthenium Chemistry

Author: Ajay Kumar Mishra

Publisher: CRC Press

Published: 2018-01-17

Total Pages: 260

ISBN-13: 1351616498

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This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.


Metal Ions in Bio-Imaging Techniques

Metal Ions in Bio-Imaging Techniques

Author: Astrid Sigel

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2021-03-08

Total Pages: 547

ISBN-13: 3110685701

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Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.