Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases
Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

Author: Christophe Wiart

Publisher: Academic Press

Published: 2013-12-16

Total Pages: 415

ISBN-13: 0123983835

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Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. - Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research - Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area - Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease - Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Phytochemicals as Lead Compounds for New Drug Discovery
Phytochemicals as Lead Compounds for New Drug Discovery

Author: Chukwuebuka Egbuna

Publisher: Elsevier

Published: 2019-09-07

Total Pages: 382

ISBN-13: 0128178914

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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. - Presents fundamental concepts and factors affecting choice for plant-based products - Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward - Highlights recent advances in computational-based drug discovery - Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

The Benefits of Natural Products for Neurodegenerative Diseases
The Benefits of Natural Products for Neurodegenerative Diseases

Author: M. Mohamed Essa

Publisher: Springer

Published: 2016-09-20

Total Pages: 497

ISBN-13: 3319283839

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Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health
Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

Author: Kavita Sharma

Publisher: BoD – Books on Demand

Published: 2021-04-07

Total Pages: 358

ISBN-13: 1838808876

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Bioactive compounds are abundant in nature, particularly in plants, which have the capacity to synthesize phenolics, flavonoids, caffeine, carotenoids, and much more. Different bioactive compounds can change or alter the life process due to their different biological activities. This book examines bioactive compounds and their sources, structures, and potential uses in various industries, including pharmaceuticals, medicine, cosmetics, and food processing.

Parkinson's Disease in the Older Patient
Parkinson's Disease in the Older Patient

Author: Jeremy R. Playfer

Publisher: Radcliffe Publishing

Published: 2008

Total Pages: 428

ISBN-13: 1846191149

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This text represents a detailed guide to the holistic assessment and the management of older patients with Parkinson's disease, based on current concepts in the management of chronic diseases and the caring strategies required in the four stages.

Plant-derived Bioactives
Plant-derived Bioactives

Author: Mallappa Kumara Swamy

Publisher: Springer Nature

Published: 2020-05-11

Total Pages: 619

ISBN-13: 9811517614

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Plants produce a vast number of bioactive compounds with different chemical scaffolds, which modulate a diverse range of molecular targets and are used as drugs for treating numerous diseases. Most present-day medicines are derived either from plant compounds or their derivatives, and plant compounds continue to offer limitless reserves for the discovery of new medicines. While different classes of plant compounds, like phenolics, flavonoids, saponins and alkaloids, and their potential pharmacological applications are currently being explored, their curative mechanisms are yet to be understood in detail. This book is divided into 2 volumes and offers detailed information on plant-derived bioactive compounds, including recent research findings. Volume 1, Plant-derived Bioactives: Chemistry and Mode of Action, discusses the chemistry of highly valued plant bioactive compounds and their mode of actions at the molecular level. Volume 2, Plant-derived Bioactives: Production, Properties and Therapeutic Applications, explores the sources, biosynthesis, production, biological properties and therapeutic applications of plant bioactives. Given their scope, these books are valuable resources for members of the scientific community wishing to further explore various medicinal plants and the therapeutic applications of their bioactive compounds. They appeal to scholars, teachers and scientists involved in plant product research, and facilitate the development of innovative new drugs.

Medicinal Plants of Sabah, North Borneo
Medicinal Plants of Sabah, North Borneo

Author: Christophe Wiart

Publisher: CRC Press

Published: 2024-06-28

Total Pages: 319

ISBN-13: 1040033350

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Researchers in the field of natural product chemistry and pharmacology focus on discovering new drugs from medicinal plants. The medicinal plants of Sabah (North Borneo), many of which are found in all of Asia and the Pacific, represent a vast array of resources that could be used for the discovery of drugs and the development of cosmetics as well as functional food. No other book focuses on the medicinal plants from this part of the globe in such depth. The author is well known in natural products and this text will appeal to a global audience in presenting the botanical description, chemical constituents, pharmacology, pharmaceutical, cosmetic, and functional food potentials of these plants. Features: Describes in a phylogenetic order the habitats, distributions, botanical descriptions, local names, uses, chemical constituents, pharmacological activities, and toxic effects of more than 250 species of medicinal plants of Sabah Provides a selection of botanical plates of medicinal plants endemic to Sabah, hand-drawn by the author Provides comment sections to invite further research on the topic of the development of drugs, dietary products, and cosmetics from Sabah medicinal plants

Handbook of Medicinal Plants of the World for Aging
Handbook of Medicinal Plants of the World for Aging

Author: Christophe Wiart

Publisher: CRC Press

Published: 2023-12-11

Total Pages: 359

ISBN-13: 1003819486

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Handbook of Medicinal Plants of the World for Aging: Botany, Ethnopharmacology, Natural Products, and Molecular Pathways provides an unprecedented comprehensive overview of more than 100 plants used globally as medicine with the potential to prevent premature aging. This handbook covers the pathophysiology of aging from the molecular and cellular to the organ levels, as well as the current state of knowledge about the modes of action of natural products from plants on the pathophysiological pathways related to the (i) cardiovascular system and metabolism, (ii) central nervous system, (iii) kidneys, (iv) bones, (v) skin and hair, and (vi) immune system. Medicinal plants are presented alphabetically. For each plant is indicated the botanical family, synonyms, and common names in English, French, German, Portuguese, Russian, and Spanish. For each plant, the reader will also find the part used, active principles, medical history, contemporary medicinal uses, as well as pharmacological, clinical, and toxicological studies. The bibliographical references have been carefully selected for their relevance. This handbook is intended for medical doctors, nurses, pharmacists, dieticians, and nutritionists, as well as readers with interest in health food and herbs. FEATURES • Alphabetical presentation of over 100 medicinal plants and the pharmacological rationales for their uses for aging • Discusses the medical history, current medicinal uses, and potential candidates for the prevention of premature aging • Introduces the molecular mechanism of natural products on the pathophysiology of aging • Contains a selection of bibliographic references • A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries Handbook of Medicinal Plants of the World for Aging: Botany, Ethnopharmacology, Natural Products, and Molecular Pathways presents comment sections that invite further research and reflection on the fascinating and timely subject of herbals for healthy aging. This is an ideal reference text for medicinal plant enthusiasts.

Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants, Volume 1
Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants, Volume 1

Author: Bharat Singh

Publisher: CRC Press

Published: 2023-10-24

Total Pages: 575

ISBN-13: 1000934918

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This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest. In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures. This volume: · Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. · Presents ethnopharmacological applications of various species of the 56 genera included in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world. · Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities. · Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis. · Provides a complete overview of each species of 56 genera and complete information up to 2022. Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, and biological and pharmacological activities of plants.

Botanical Medicine for Women's Health E-Book
Botanical Medicine for Women's Health E-Book

Author: Aviva Romm

Publisher: Elsevier Health Sciences

Published: 2017-01-25

Total Pages: 671

ISBN-13: 0702065137

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Use herbal medicines to treat women at any stage of life! Botanical Medicine for Women's Health, 2nd Edition provides an evidence-based, patient-centered approach to botanical interventions for many different medical conditions. More than 150 natural products are covered, showing their benefits in gynecologic health, fertility and childbearing, and menopausal health. This edition includes new full-color photos of herbal plants along with a discussion of the role of botanicals in healthy aging. Written by Aviva Romm, an experienced herbalist, midwife, and physician, this unique guide is an essential resource for everyday practice of herbal medicine. Winner of the 2010 American Botanical Council's James A. Duke Excellence in Botanical Literature Award! - Current, evidence-based information covers more than 150 botanicals for over 35 different conditions. - Case studies provide realistic scenarios and help you apply the content to the real world. - Treatment and formula boxes summarize the most important information. - Color illustrations and photographs of plants enable you to identify herbs visually as well as by substance make-up. - Logical chapter organization begins with the principles of herbal medicine and then covers women's health conditions organized chronologically by lifecycle, from teen and reproductive years to midlife and mature years. - Appendices include practical, at-a-glance information on common botanical names, chemical constituents of medicinal plants, and a summary table of herbs for women's health. - NEW! Updates reflect the latest research and the most current information. - NEW Full-color design and detailed, professional color photos of plants make this a unique, essential resource. - NEW! Coverage of the role of botanicals in healthy aging for women features phytoestrogens, Ayurvedic/Chinese herbs, and discussions of health promotion.