Annotation Contains 42 seminal papers illustrating advances in cell biology, along with brief commentaries that place the papers in historical and intellectual context. All papers are studies of eukaryotes, and are grouped according to themes of genome organization and replication, transcription, nuclear envelope and nuclear import, mitosis and cell cycle control, cell membrane and extracellular matrix, protein synthesis and membrane traffic, and cytoskeleton. Lacks a subject index. Gall teaches embryology at the Carnegie Institution. McIntosh teaches cell biology at the University of Colorado. Annotation c. Book News, Inc., Portland, OR (booknews.com).
Landmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. - Includes detailed analysis of classically designed and executed experiments - Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries - Provides critical analysis of the history of molecular biology to inform the future of scientific discovery - Examines the machinery of inheritance and biological information handling
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Evidence-based medicine is a concept that has come to the fore in the past few years. Clinicians are increasingly encouraged to practise patient management based on available evidence in the scientific literature. For example, new pharmacological therapies are only used when large randomized trials have 'proven' that a particular drug is better than existing ones. This is also the case in surgical specialties, although surgery has traditionally seen a lack of useof this information, with individual surgeon's preferences being most influential in treatment choices. However, more recently, there has been a large expansion of trials and studies aimed at providingsurgeons with information to guide their choices using firm evidence. This new edition has been revised and expanded to include new data where relevant, and also features a new chapter on pituitary surgery. Landmark Papers in Neurosurgery 2e remains a key collection of the most important trials and studies in neurosurgery, allowing the reader to rapidly extract key results, and making it essential reading for all neurosurgeons and trainees in the field.
Otolaryngological conditions affect people of all ages from newborns to older members of society, and have serious consequences for daily functions such as breathing, taste, and communication. There is a constant desire to understand the best evidence for current practice in a constantly evolving field such as medicine, and key publications underpin this contemporary knowledge. Landmark Papers in Otolaryngology presents a distilled summary of 99 of the classic, ground-breaking, and significant publications in the field of otolaryngology that are of essential relevance to the speciality today. Each paper is described, critiqued, and brought into the context of modern-day practice by a carefully selected team of international authorities from each subspecialist area to provide the reader with a clear understanding of the key publications in otolaryngology. Whether your aim is to understand the origins of otolaryngology, to review advances in key areas, or to gain insight from experts, this book offers a wealth of knowledge for everyone in the field, from the new trainee to the senior clinician. Landmark Papers in Otolaryngology is an invaluable and easily accessible reference text for all practitioners in the field, as well as those in overlapping specialities such as maxillofacial surgery, neurology, and plastic surgery.
Advances in the practice of psychiatry have occurred in "fits and starts" over the last several decades. These advances are evident to anyone long affiliated with the field and are best appreciated through direct experience of living through the times. These advances can also be gleaned from historical overviews in textbooks or the recollections of one's teachers and mentors. Returning to the original papers that have ushered in these changes is rarely done for various, mostly practical, reasons. Filtering through thousands of articles in psychiatry may prove daunting, access to the manuscripts may be limited (especially for papers not available electronically), and understanding their impact requires a broader context. Moreover, with so much active research currently occurring in various branches of psychiatry, current practitioners or trainees may find their attention focused on the present, and this is reinforced by electronic search algorithms, which return articles in reverse chronological order. Not surprisingly, citations for articles in virtually all fields decline precipitously for articles over five years old. As scholars and professionals, we are losing touch with our academic heritage. Yet navigating the future of psychiatry requires a firm understanding of its past. This resource serves as a guide for anyone seeking to understand the evolution of psychiatry as a scientific discipline. It does so by summarizing over 100 landmark papers in psychiatry and placing their scientific contributions within a historical context. An introductory section sets the stage for the major theoretical constructs within the field, with chapters devoted to ontology and nosology. Subsequent sections examine major facets of the theory and practice of psychiatry, such as pathogenesis of psychiatric illness, pharmacotherapy, psychotherapy, and somatic treatments. These sections are divided logically into chapters addressing important contributions to the understanding and treatment of specific disorders. A final section explores ethical considerations within each field. This framework echoes the complexity of psychiatry, which cannot be reduced to a single set of diagnoses or subspecialty categories. Highlighting the research trajectory of psychiatry, this resource will appeal to academics, trainees, and practitioners who desire a comprehensive, easy-to-read, up-to-date collection of psychiatry's pivotal moments. By understanding the challenges, inspirations, and insights from the past, readers will be better poised to address new and ongoing challenges within the field.
With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, "Molecular Cell Biology" has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.
The yeasts have been important experimental organisms for more than 50 years. This volume contains over 100 selected papers, in sections with introductions that describe the process of discovery and the context and significance of the research. The selections include early classics as well as recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This book is designed as a guide for a literature-based course.
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
