The Hostage Brain
Author: Bruce S. McEwen
Publisher: Rockefeller Univ. Press
Published: 1994
Total Pages: 336
ISBN-13: 9780874700565
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Author: Bruce S. McEwen
Publisher: Rockefeller Univ. Press
Published: 1994
Total Pages: 336
ISBN-13: 9780874700565
DOWNLOAD EBOOKAuthor: Florian Markowetz
Publisher: Cambridge University Press
Published: 2015-07-02
Total Pages: 287
ISBN-13: 131638098X
DOWNLOAD EBOOKWhereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Author: X. Johné Liu
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 487
ISBN-13: 1597450006
DOWNLOAD EBOOKA collection of standard and cutting-edge techniques for using Xenopus oocytes and oocytes/egg extracts to reconstitute biological and cellular processes. These readily reproducible methods take advantage of the oocyte's impressive protein abundance, its striking protein translation capacity, and its breathtaking possibilities for the assembly of infectious viral particles by single cell injection of multiple RNAs. The authors focus on the versatility of frog oocytes and egg extracts in cell biology and signal transduction, and cover all the major uses of oocytes/extracts as experimental models.
Author: Harvey F. Lodish
Publisher:
Published: 1990
Total Pages: 1344
ISBN-13: 9780716723806
DOWNLOAD EBOOKAuthor: Thomas J. Carew
Publisher: John Wiley & Sons
Published: 1998-06-29
Total Pages: 346
ISBN-13: 9780471977025
DOWNLOAD EBOOKAt the turn of the century, the pioneering neuroscientist Ramon y Cajal articulated the hypothesis that growth processes involved in the development of the central nervous system may persist into adulthood, where they might be retained to mediate the formation and maintenance of memory. Over the decades since Cajal s seminal suggestion, extensive experimental attention has been directed at elucidating the cellular and molecular mechanisms underlying both neuronal development and learning and memory. Many exciting technical and conceptual advances have been made on each front. Thus, as we approach the end of this century, the field is now poised to assess the status of Cajal s provocative hypothesis directly. This volume reflects a highly interdisciplinary dialog among experts in the fields of development and learning and memory, who came together not only to assess the validity of the general hypotheses that development and learning might share mechanistic features, but also to identify issues, preparations, and paradigms that would allow for a rigorous evaluation of ways to advance the hypothesis, on the one hand, and determine its fundamental limitations, on the other. Towards this end, the volume is organized into four levels of analysis: behavioral, systems, cellular, and molecular. At each level, neuroscientists from the general fields of development and learning engage in lively exchange of ideas which serve to highlight the similarities and differences of both the concepts and the experimental approaches used in their diverse fields. The result of this endeavor is a collection of seminal chapters and summary reports that provide a novel synthesis of important advances in two exciting areas of modern neuroscience. Goal of this Dahlem Workshop: to evaluate the validity of the general thesis that mechanisms utilized in the development of the nervous system are reutilized in the adult to mediate formation and maintenance of memory.
Author: Roberto Scatena
Publisher: Springer Science & Business Media
Published: 2012-03-08
Total Pages: 459
ISBN-13: 9400728697
DOWNLOAD EBOOKMitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Author: Phillip R. Shaver
Publisher: Amer Psychological Assn
Published: 2011
Total Pages: 422
ISBN-13: 9781433808593
DOWNLOAD EBOOKThis book provides an impressive, well-rounded, authoritative overview of the latest research and theory about human aggression. Written by a diverse phalanx of highly respected experts, from evolutionary psychologists and behavioral geneticists to developmental, social, and clinical psychologists, the chapters offer a rich assortment of perspectives and an indispensable survey of issues, facts, and theories about why and how people hurt each other. It is an ideal introduction to the modern psychology of aggression for scholars and students, and a convenient reference for specialists, journalists, and the general public.-Roy F. Baumeister, author of Evil: Inside Human Violence and Cruelty This volume is an outstanding, integrated, biopsychosocial approach to aggression ranging over the contributions of genes, neurophysiology, early life influences, social relationships, personality, and cultures and exploring the "victim perspective." Edited by internationally renowned researchers in attachment and social relationships, this gem of a book provides detailed, up-to-date access to current work by world leaders in the field. The best way of dealing aggression and becoming more compassionate is to better understand the facilitators and inhibitors of aggression, and this volume significantly contributes to this important endeavor.ùPaul Gilbert, author of The Compassionate Mind In this exciting book, leading experts cover contemporary theory, research, and practice in the psychology of aggression and violence. There is something here for everyone interested in these topics: basic theory, up-to-date reviews, and practical applications. There is a broad range of approachesùincluding evolutionary background, neuroscience and genetics, environmental influences, violence between groups, and the impact on victims.ùJohn Archer, School of Psychology University of Central Lancashire, Lancashire, United Kingdom Violence and aggression have existed as long, as humankind, and the need to understand and control these forces has only continued to grow throughout history. Thanks to the advance of psychological research within the social and behavioral sciences, as well as several other scientific disciplines, we have more knowledge than ever before about the genetic, developmental, interpersonal, and cultural causes of aggression. Yet these findings have not been integrated into meaningful discussions about how to transform aggression research into practical applications. With so many answers to the question "What makes a person violent?" there is surprisingly little insight into "How do we prevent violence?" In this comprehensive book, editors Phillip R. Shaver and Mario Mikulincer have assembled chapters from international experts to provide a broad-based and multidisciplinary analysis of aggression and violence, their negative consequences, and promising interventions. Five sections examine major theoretical perspectives, genetic and environmental determinants, and the psychological and relational processes underlying human violence and aggression. The tone of the book is realistic in its investigation of violence as an inherent part of human genetics and interaction, but hopeful in its exploration of research-based interventions aimed at reducing violence in future generations. In its assessment of aggression and violence across individual, relational and societal levels, this book will engage a broad audience. This book is part of the Herzliya Series on Personality and Social Psychology. Phillip R. Shaver, PhD,, a social and personality psychologist, is Distinguished Professor of Psychology at the University of California, Davis. Before moving there, he served on the faculties of Columbia University, New York University, University of Denver, and State University of New York at Buffalo. He has coauthored and co-edited numerous books. He is a member of the editorial boards of Attachment and Human Development, Personal Relationships, the Journal of Personality and Social Psychology, and Emotion, and has served on grant review panels for the National Institutes of Health and the National Science Foundation. He has been executive officer of the Society of Experimental Social Psychology and is a fellow of both the American Psychological Association and the Association for Psychological Science. Dr. Shaver received a Distinguished Career Award from the International Association for Relationship Research and has served as president of that organization. Mario Mikulincer, PhD, is professor of psychology and dean of the New School of Psychology at the Interdisciplinary Center in Herzliya, Israel. He has published 3 books and over 280 scholarly journal articles and book chapters. He is a member of the editorial boards of several scientific journals, including the Journal of Personality and Social Psychology, Psychological Inquiry, and Personality and Social Psychology Review, and has served as associate editor of two journals. Recently, he was elected to serve as chief editor of the Journal of Social and Personal Relationships. He is a fellow of the Society for Personality and Social Psychology and the Association for Psychological Sciences. He received the EMET Prize in Social science for his contributions to psychology and the Berscheid-Hatfield Award for Distinguished Mid-Career Achievement from the International Association for Relationship Research
Author: Kenneth J. Muller
Publisher:
Published: 1981
Total Pages: 0
ISBN-13: 9781936113095
DOWNLOAD EBOOKIn the 19th century, the medicinal applications of leeches prompted basic research into their neurobiology, reproduction, development, and anatomy; subsequently, leeches became an important model for understanding the nervous system. In this monograph, each chapter provides a narrative account of experimental work on a particular area of leech neurobiology, and explains its significance for the broader field of neuroscience. The appendices describe methods for maintaining and manipulating leeches in the laboratory and include an atlas of neurons in the leech Hirudo medicinalis. Extensively illustrated, this book is a classic in the field and is considered a "must read" for neuroscientists and those interested in leech biology. It has been out of print for many years; however, some recent inquiries have prompted us to reprint it and make it available at an affordable price.
Author: M. Neale
Publisher: Springer Science & Business Media
Published: 2013-03-09
Total Pages: 503
ISBN-13: 9401580189
DOWNLOAD EBOOKFew would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package. The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears.