Not so long ago, antibiotics were considered miracle cures. The introduction of penicillin turned once fatal infections into minor problems. Tuberculosis, a fatal disease of the early twentieth century, seemed to disappear, but the appearance of microbes that are highly resistant to antibiotics in the late twentieth century meant that minor health problems were major again, and tuberculosis re-entered the scene. Author Nancy Day explains the history of antibiotics and how bacteria and protozoas have become resistant to antibiotic treatment. Day also discusses the fight against the overuse and abuse that have made antibiotics less effective.
An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.
Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Superbugs describes this growing global threat, the systematic failures that have led to it, and solutions that governments, industries, and public health specialists can adopt.--
"Provides information about tuberculosis and other drug-resistant diseases, including treatment, diagnosis, history, medical advances, and true stories about people with the diseases"--Provided by publisher.
Drug-resistant bacteria — known as superbugs — are one of the biggest medical threats of our time. Here, a doctor, researcher, and ethics professor tells the exhilarating story of his race to beat them and save countless lives. When doctor Matt McCarthy first meets Jackson, a mechanic from Queens, it is in the ER, where he has come for treatment for an infected gunshot wound. Usually, antibiotics would be prescribed, but Jackson’s infection is one of a growing number of superbugs, bacteria that have built up resistance to known drugs. He only has one option, and if that doesn’t work he may lose his leg or even his life. On the same day, McCarthy and his mentor Tom Walsh begin work on a groundbreaking clinical trial for a new antibiotic they believe will eradicate certain kinds of superbugs and demonstrate to Big Pharma that investment in these drugs can save millions of lives and prove financially viable. But there are countless hoops to jump through before they can begin administering the drug to patients, and for people like Jackson time is in short supply. Superbugs is a compelling tale of medical ingenuity. From the muddy trenches of the First World War, where Alexander Fleming searched for a cure for soldiers with infected wounds, to breakthroughs in antibiotics and antifungals today that could revolutionise how infections are treated, McCarthy takes the reader on a roller-coaster ride through the history — and future — of medicine. Along the way, we meet patients like Remy, a teenage girl with a dangerous and rare infection; Donny, a retired firefighter with a compromised immune system; and Bill, the author’s own father-in-law, who contracts a deadly staph infection. And we learn about the ethics of medical research: why potentially life-saving treatments are often delayed for years to protect patients from exploitation. Can McCarthy get his trial approved and underway in time to save the lives of his countless patients infected with deadly bacteria, who have otherwise lost all hope?
The volume presents an up-to-date collection of methodologically sensitive contributions providing mainly enthusiastic, at times also critical support for the cognitive-linguistic enterprise. The book is important for the advancement of cognitive linguistics because the contributions demonstrate the seriousness of its ambitions to develop into a set of testable linguistic approaches. For the same reason, the volume is a contribution to our understanding of language in general, since it puts a promising modern approach on firmer ground. Assets of the book include the wide range of linguistic phenomena studied (individual concepts, fundamental semantic problems like vagueness and polysemy, grammatical issues incl. gender and tense, collocations, constructions and speech acts) and the scope of applied perspectives including lexicographical, computational, developmental and critical discourse ones. The languages investigated are English, German, Dutch, Polish and Italian. Common to the contributions is the desire to bring together observed patterns of linguistic usage with concepts and models established in cognitive linguistics. In addition, all contributions have an empirical basis and emphasize the need to rely on a sound methodology. The linguistic phenomena investigated span the range from the lexico-conceptual and collocational level to constructions, grammatical categories and functions. Two complementary perspectives of language and cognition are represented in the volume: In one group, the established methods of psycholinguistic experimentation, quantitative corpus analysis and computational simulation are exploited to demonstrate the viability and to increase the plausibility of cognitive-linguistic thinking. The second group tests well-known cognitive-linguistic approaches like Conceptual Metaphor Theory, the Theory of Idealized Cognitive Models and Construction Grammar against authentic data demonstrating their applicability and explanatory potential. Both groups include contributions reaching beyond the scope of traditional cognitive-linguistic topics, e.g. by taking a critical stance of reductionist cognitive thinking. The volume is of interest to cognitive linguists, psycholinguists, theoretical linguists, lexicologists, and lexicographers.
This open access book explores a special species of trouble afflicting modern societies: creeping crises. These crises evolve over time, reveal themselves in different ways, and resist comprehensive responses despite periodic public attention. As a result, these crises continue to creep in front of our eyes. This book begins by defining the concept of a creeping crisis, showing how existing literature fails to properly define and explore this phenomenon and outlining the challenges such crises pose to practitioners. Drawing on ongoing research, this book presents a diverse set of case studies on: antimicrobial resistance, climate change-induced migration, energy extraction, big data, Covid-19, migration, foreign fighters, and cyberattacks. Each chapter explores how creeping crises come into existence, why they can develop unimpeded, and the consequences they bring in terms of damage and legitimacy loss. The book provides a proof-of-concept to help launch the systematic study of creeping crises. Our analysis helps academics understand a new species of threat and practitioners recognize and prepare for creeping crises.
The 1918 influenza pandemic. The Polio scourge. The AIDS epidemic. The Ebola and Zika outbreaks. Modern history has seen numerous deadly viruses and pandemics that have harmed or killed hundreds of millions of people. And the history is ongoing. The world is facing antibiotic-resistant “superbugs” and infectious diseases tied to climate change, and our previously reliable medicines and treatments no longer always work. What causes these outbreaks, how they spread, and how best to contain and combat them are often open to debate. The most informed opinions from the most respected doctors, researchers, and public health officials are found here, presenting various perspectives on our current and future health and offering both cause for hope and reason to fear.
