Annual Report of the Officers of the Town
Author:
Publisher:
Published: 1888
Total Pages: 520
ISBN-13:
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Cystogenesis
Author: Jong Hoon Park
Publisher: Springer
Published: 2016-10-12
Total Pages: 128
ISBN-13: 9811020418
DOWNLOAD EBOOKAutosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Podocytopathy
Author: Z.-H. Liui
Publisher: Karger Medical and Scientific Publishers
Published: 2014-05-16
Total Pages: 274
ISBN-13: 3318026514
DOWNLOAD EBOOKThe podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Final Report
Author: International Commission on the Holocaust in Romania
Publisher:
Published: 2005
Total Pages: 424
ISBN-13:
DOWNLOAD EBOOKThe International Commission on the Holocaust in Romania was established in October 2003 on the initiative of Ion Iliescu, the President of Romania; this final report was presented to him in November 2004. The aim of the Commission was to research the facts and determine the truth about the Holocaust in Romania during World War II. The report examines various aspects of the state-organized participation of Romania in the mass murder of Jews in Romania and in Romanian-controlled territories, as well as in northern Transylvania where the genocide was perpetrated by the Nazis and their Hungarian allies. Inter alia, it discusses antisemitism and the evolution of Romanian anti-Jewish policies from the late 1930s to 1944, the impact of the Soviet annexation of Bessarabia and Northern Bukovina on antisemitism in Romania, anti-Jewish incidents in 1940 and the pogroms in Bucharest and Iaşi, mass murders of Jews in the recaptured provinces and deportation to Transnistria in 1941, mass murder of Jews in Odessa and in Transnistrian camps, the "Romanianization" of the economy and the expropriation of Romanian Jews, the reaction of the Jewish community in Romania to anti-Jewish policies, and the personal responsibility of Ion Antonescu for the genocide. Relates, also, to war crimes trials held in Romania, and to the trivialization of the Holocaust and its "selective" and outright denial in postwar Romania.
Secondary Fracture Prevention
Author: Markus J. Seibel
Publisher: Academic Press
Published: 2018-10-11
Total Pages: 0
ISBN-13: 9780128131367
DOWNLOAD EBOOKSecondary Fracture Prevention: An International Perspective presents practitioners and academic clinicians with a better understanding of secondary fracture prevention and models of care from a variety of settings and countries. This must-have guide provides practitioners and academic clinicians with essential information about this broad clinical and research topic that extends across the globe. Preventing secondary fractures starts with assessing what works and what does not work, reviewing major society guidelines, and what workup and management is necessary. This book reviews these topics and provides the rationale for pursuing a workup to prevent fractures in this patient population.
Social Security Programs and Retirement around the World
Author: Axel Börsch-Supan
Publisher: University of Chicago Press
Published: 2025-03-10
Total Pages: 0
ISBN-13: 0226836363
DOWNLOAD EBOOKA global analysis of the effects of social security reforms on the retirement incentives and labor force trends of older workers. Employment among older men and women has increased dramatically in recent years, reversing a downward trend in the closing decades of the twentieth century. Social Security Programs and Retirement around the World examines how changing retirement incentives have reshaped labor force participation trends among older workers. The chapters feature country-specific analyses for Belgium, Canada, Denmark, France, Germany, Italy, Japan, Netherlands, Spain, Sweden, the United Kingdom, and the United States. They find that while there is significant heterogeneity across countries, the reforms of recent decades have generally reduced the implicit tax on work at older ages. These changes correlate positively with labor force participation. The studies exploit the variation in the timing and extent of reforms of retirement incentives and employ microeconometric methods to investigate whether this correlation reflects a causal relationship. Policy changes appear to have contributed to rising labor force activity, but other factors like the role of women in the labor force, improved health, and changes in private pensions likely also play important roles.
An Economic Review of the Patent System
Author: Fritz Machlup
Publisher:
Published: 1958
Total Pages: 100
ISBN-13:
DOWNLOAD EBOOKAt head of title: 85th Cong., 2d sess. Committee print. Bibliography: p. 81-86.
Managing National Innovation Systems
Author: Organisation for Economic Co-operation and Development
Publisher: OECD Publishing
Published: 1999
Total Pages: 132
ISBN-13:
DOWNLOAD EBOOKThis study defines the aims and tools of a new innovation policy and identifies examples of good policy practice recently implemented in OECD countries.
Managerial and Organizational Cognition
Author: Colin Eden
Publisher: SAGE
Published: 1998-03-19
Total Pages: 278
ISBN-13: 9781446231913
DOWNLOAD EBOOKInterest in the field of managerial and organizational cognition has been intense over the last few years. This book explores and provides an in-depth overview of the latest developments in the area and presents answers to the questions accompanying its growth: Is the field distinctive? How does it extend our understanding of managerial processes? From different disciplinary perspectives and empirical settings, the contributors study patterns of managerial cognition. In particular, the longitudinal approach reflected in the volume contributes to its impact as a grounded, practice-based analysis of cognition in organizations.
Godel
Author: John L. Casti
Publisher:
Published: 2009-04-21
Total Pages: 222
ISBN-13: 0786747609
DOWNLOAD EBOOKKurt Gödel was an intellectual giant. His Incompleteness Theorem turned not only mathematics but also the whole world of science and philosophy on its head. Shattering hopes that logic would, in the end, allow us a complete understanding of the universe, Gödel's theorem also raised many provocative questions: What are the limits of rational thought? Can we ever fully understand the machines we build? Or the inner workings of our own minds? How should mathematicians proceed in the absence of complete certainty about their results? Equally legendary were Gödel's eccentricities, his close friendship with Albert Einstein, and his paranoid fear of germs that eventually led to his death from self-starvation. Now, in the first book for a general audience on this strange and brilliant thinker, John Casti and Werner DePauli bring the legend to life.
