Sex, drugs, rocks, gold, murder, war, mass poisonings, the deaths of Napoleon, Tchaikovsky, Mozart, and others are all linked by one element - arsenic! Arsenic has been around since the beginning of time and the word has become a metaphor for poison with associated shock value. The general public are fearful of any possible exposure to it and yet it holds a certain dark and eerie fascination! The average person has only one idea about arsenic - it is poison - and this reputation has a sound base. Some arsenic compounds are very toxic and have been used with criminal intent from the time of the.
Sex, drugs, rocks, gold, murder, war, mass poisonings, the deaths of Napoleon, Tchaikovsky, Mozart, and others are all linked by one element - arsenic! Arsenic has been around since the beginning of time and the word has become a metaphor for poison with associated shock value. The general public are fearful of any possible exposure to it and yet it holds a certain dark and eerie fascination! The average person has only one idea about arsenic - it is poison - and this reputation has a sound base. Some arsenic compounds are very toxic and have been used with criminal intent from the time of the ancient Romans to the present day. Up until now, there has been no book that covers arsenic with such breadth. This book is a general appreciation of how much the element, arsenic, has become part of our lives in an entertaining style covering the years 1000 BC to the present day. The coverage of the chemistry, toxicology, and medicinal aspects is deliberately kept at a level for the general reader to understand. It covers the way in which this ubiquitous element and its compounds have influenced the lives of the people of the world. The author's objective in writing this book was not to elaborate on the vast chemistry of the element, but to try to reveal to the general reader how the element and its compounds have become embedded in our social fabric, for good and for ill. No other element comes close in this regard and he uses the word sociochemistry to describe this interface between society and chemistry. The book covers a broad range of topics including the use of arsenic in human medicine in many cultures from Chinese medicine to the beginning of chemotherapy. This peaked in the western world in the early 20th century, with Ehrlich's discovery of salvarsan, an arsenic-based cure for syphilis that gave rise to the field of chemotherapy. Salvarsan and related compounds were eventually displaced by antibiotics such as penicillin. Arsenic trioxide has staged a comeback, however, and is being used as a successful treatment for a form of leukemia. Other chapters cover arsenic compounds which were widely used in agriculture and wood preservation during the 20th century and their associated myths as well as arsenic compounds as chemical warfare agents and the resulting stockpile. The topic of arsenic in the environment is discussed in depth - arsenic is all around us - in our soil, our water, and our food, and our bodies have adapted to its presence and it does not usually pose a problem. However, the natural presence of high concentrations of arsenic in drinking water currently threatens the lives of millions of people in India, Bangladesh, Mexico and elsewhere. It also covers mining and pesticide manufacturing which can lead to high local arsenic concentrations in soils, slag heaps and mine tailings which, when located close to human activities, can produce human health risks. Other chapters cover a variety of topics including: " A proposed connection between arsenic and Cot Death (SIDS) which caused panic " The high concentration of arsenic in kelp products-is this harmful? " What about the 237,000 tonnes of arsenic trioxide stored in a mine in Canada? " How toxic is arsenic anyway, and how do you assess the risks of exposure? " How did Napoleon die? These and many other topics are addressed at a level that will result in understanding without delving into too much technical detail or requiring a degree in chemistry. Essential reading for everyone with a general interest in science, this illuminating text covers a broad range of topics.
The shocking story of a deadly trend in Victorian wallpaper design, illustrated by beautiful and previously unseen arsenic-riddled designs from the British National Archives In Germany, in 1814, Wilhelm Sattler created an extremely toxic arsenic and verdigris compound pigment, Schweinfurt green–known also as Paris, Vienna, or emerald green–which became an instant favorite amongst designers and manufacturers the world over, thanks to its versatility in creating enduring yellows, vivid greens, and brilliant blues. Most insidiously, the arsenic-laced pigment made its way into intricately patterned, brightly colored wallpapers and from there, as they became increasingly in vogue, into the Victorian home. As its use became widespread, commercial arsenic mines increased production to meet the near-insatiable demand. Not least of which was the UK’s largest mining plant, DGC whose owner was William Morris, originator of the British Arts and Crafts movement and arguably the finest wallpaper designer of his generation. Bitten by Witch Fever (Morris’s own phrase to dismiss arsenic- and- wall-paper-related public health concerns in 1885) tells this fatal story of Victorian home décor, building upon new research conducted especially for this book by the British National Archive, on their own samples. Spliced between the sections of text are stunning facsimiles of the wallpapers themselves.
For centuries, arsenic's image as a poison has been inextricably tied to images of foul play. In King of Poisons, John Parascandola examines the surprising history of this deadly element. From Gustave Flaubert to Dorothy Sayers, arsenic has long held a place in the literary realm as an instrument of murder and suicide. It was delightfully used as a source of comedy in the famous play Arsenic and Old Lace. But as Parascandola shows, arsenic has had a number of surprising real-world applications. It was frequently found in such common items as wallpaper, paint, cosmetics, and even candy, and its use in medical treatments was widespread. American ambassador Clare Boothe Luce suffered from exposure to arsenical paint in her study, and Napoleon's death has long been speculated to be the result of accidental or intentional poisoning. But arsenic poisoning is still a public menace. In the neighborhood surrounding American University in Washington, D.C., the army has undertaken a massive cleanup of artillery shells and bottles containing chemical warfare agents such as arsenical lewisite after a number of workmen and residents became ill. Arsenic contamination of the water supply in Bangladesh and in West Bengal, India, is a major public health problem today as well. From murder to crime fiction, from industrial toxin to chemical warfare, arsenic remains a powerful force in modern life.
The planning and writing of this book has taken rather longer than I had originally intended; what began as a modest literary project for two second-year medical students has expanded over eight years to become a complete book. The subject matter lent itself all too easily to a sen sationalist approach yet, on the other hand, a strictly scientific approach would probably have resulted in a dull dry text of little interest to the general reader. I have therefore attempted to bridge the gap and make the book intelligible and entertaining to the non-special ist, but at the same time ensuring that it is factually correct and adequately researched for the scientist or clinician. I have always been impressed by Sir J .G. Frazer's introduction to his classic book The Golden Bough in which he apologizes for the fact that an article originally intended merely to explain the rules of succession to the priesthood of Diana at Aricia had expanded, over a period of thirty years, to twelve volumes. The present work cannot pretend to such heady levels of academic excellence.
Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: chemistry of As, Sb and Bi biological chemistry of arsenic biological chemistry of Sb and Bi arsenic and antimony speciation in environmental and biological samples arsenic in traditional chinese medicine arsenic in aquifers biomethylation of As, Sb and Bi uptake of metalloids by cells bismuth complexes of porphyrins and their potential in medical applications Helicobacter pylori and bismuth metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients anticancer properties of As, Sb and Bi radio-Bi in cancer therapy genotoxicity of As, Sb and Bi metallomics as a new technique for As, Sb and Bi metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.
Up to 200 million people in 70 countries are at risk from drinking water contaminated with arsenic, which is a major cause of chronic debilitating illnesses and fatal cancers. Until recently little was known about the mobility of arsenic, and how redox transformations determined its movement into or out of water supplies. Although human activities contribute to the release of arsenic from minerals, it is now clear that bacteria are responsible for most of the redox transformation of arsenic in the environment. Bacterial oxidation of arsenite (to the less mobile arsenate) has been known since 1918, but it was not until 2000 that a bacterium was shown to gain energy from this process. Since then a wide range of arsenite-oxidizing bacteria have been isolated, including aerobes and anaerobes; heterotrophs and autotrophs; thermophiles, mesophiles and psychrophiles. This book reviews recent advances in the study of such bacteria. After a section on background—geology and health issues—the main body of the book concerns the cellular machinery of arsenite oxidation. It concludes by examining possible applications. Topics treated are: The geology and cycling of arsenic Arsenic and disease Arsenite oxidation: physiology, enzymes, genes, and gene regulation. Community genomics and functioning, and the evolution of arsenite oxidation Microbial arsenite oxidation in bioremediation Biosensors for arsenic in drinking water and industrial effluents
In the 1950s, the residents of the southwestern coastal areas of Taiwan suffered greatly from Blackfoot disease (BFD) due to the consumption of arsenic-contaminated groundwater. Groundwater with high levels of arsenic in southwestern and northeastern Taiwan received much attention. After arsenic-safe tap water was utilized for drinking instead of g
