Haunted by the murderous demons of her past, Kathleen Freeborne rips down her shingle as a paranormal investigator and hammers up a new one as a clairvoyant, hoping to better the lives of her shell-shocked clients. Her dreams of a harmonious life are quickly shattered when she feels a man's terrifying rage coursing through her body. With the help of local police, she investigates disturbing events and learns the shocking truth—a feral animal is infecting locals with a rage virus. Struggling with a traumatized mind, Kathleen discovers the spread of the virus might be linked to a successful businessman and perhaps even government officials. Assembling pieces of a macabre jigsaw puzzle, she learns she is being hunted by a professional hit man. Adding another layer of terror, her peaceful home is attacked by a pack of frothing, rage-infected zombies. She’s unwittingly plunged into a grueling journey for self-preservation and a search for the horrifying truth behind the rage virus.
From New York Times Bestselling author (creator of the Netflix series V Wars), Jonathan Maberry comes the first in a brand new series featuring Joe Ledger and Rogue Team International. A small island off the coast of Korea is torn apart by a bioweapon that drives everyone—men, women, and children—insane with murderous rage. The people behind the attack want Korea reunified or destroyed. No middle ground. No mercy. Soon Japan, China, and the United States are pushed to the brink of war, while terrorists threaten to release the rage bioweapon in a way of pure destructive slaughter. Joe Ledger leads his newly formed band of international troubleshooters in their first mission to stop the terror cell, fighting alongside agents from North and South Korea. With the lives of billions at stake, Ledger is willing to bring his own brand of terror to this frightening new war.
As a strung-out team of paranormal investigators approach the shocking truth surrounding deadly rage-filled attacks in an unassuming small town, dangerous roadblocks quickly emerge. Kathleen Freeborne discovers their inner demons are preventing them from getting to the bottom of the sudden and violent outbursts. Her once loyal and loving boyfriend has suddenly become distant and cold, withdrawing into an alcoholic abyss. Her best friend starts keeping disturbing secrets from the team and retreating into a catatonic shell of her former self. Meanwhile, Detective Blaine Redmond, close to learning the disturbing truth behind the uncontrolled aggression possessing unsuspecting townsfolk, abruptly vanishes. Including extensive research from actual paranormal investigations, Poison Rage is a chilling and mind-bending examination of haunted happenings that paranormal investigators—often in the face of life-threatening consequences—choose to confront.
The immune system detects "danger" through a series of what we call pathogen-associated molecular patterns (PAMPs) or damage-associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. PAMPs are molecules associated with groups of pathogens that are small molecular motifs conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors. A vast array of different types of molecules can serve as PAMPs, including glycans and glycoconjugates. Bacterial lipopolysaccharides (LPSs), endotoxins found on the cell membranes of Gram-negative bacteria, are considered to be the prototypical class of PAMPs. LPSs are specifically recognized by TLR4, a recognition receptor of the innate immune system. Other PAMPs include bacterial flagellin (recognized by TLR5), lipoteichoic acid from Gram-positive bacteria, peptidoglycan, and nucleic acid variants normally associated with viruses, such as double-stranded RNA, recognized by TLR3 or unmethylated CpG motifs, recognized by TLR9. DAMPs, also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial, mesenchymal, etc.) and injured tissue. Some endogenous danger signals include heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular matrix breakdown products such as hyaluronan fragments, neuromediators, and cytokines like the interferons (IFNs). Non-protein DAMPs include ATP, uric acid, heparin sulfate, and DNA. Furthermore, accumulating evidence supports correlation between alarmins and changes in the microbiome. Increased serum or plasma levels of these DAMPs have been associated with many inflammatory diseases, including gastric and intestinal inflammatory diseases, graft-versus-host disease (GVHD), sepsis and multiple organ failure, allergies particularly in the lungs, atherosclerosis, age-associated insulin resistance, arthritis, lupus, neuro-inflammation/degeneration and more recently in tumors, which is particularly interesting with the emergence of immunotherapies. Therapeutic strategies are being developed to modulate the expression of these DAMPs for the treatment of these diseases. A vast number of reviews have already been published in this area; thus, in an effort to not duplicate what has already been written, we will focus on recent discoveries particularly in disease models that are epidemic in Western society: intestinal chronic inflammatory diseases including GVHD and its relationship with the microbiome, chronic infectious diseases, allergies, autoimmune diseases, neuroinflammation and cancers. We will also focus on the basic cellular roles of macrophages, T cells and B cells. This research topic brings together sixteen articles that provide novel insights into the mechanisms of action of DAMPS/alarmins and their regulation and subsequent immunologically driven responses.
Summary: As the world reels from the effects of the COVID-19 pandemic, a more devastating virus has infected the global population. It is a spiritual virus, and it has triggered the rage, offense, and murderous attacks that have exploded in our nation and around the world. If left unchecked, this virus leads to insanity, affecting the mind and body. We see the results all around us-and people have no idea it is ruling their lives. Is there a vaccine? There is. But first we must recognize that the virus exists and that it is being passed from person to person at unprecedented rates. Are you infected? This can be determined by taking a simple test. There is also a simple cure. The question is: are we willing to take it and stop this spiritual pandemic before it takes over?
In the fight against zombies, our most important weapons are our brains. It's time to unleash them. Think you know a thing or two about zombies? Think again. If you’re going to keep your wits – and your brains – about you during a zombie attack, you need expert advice. Braaaiiinnnsss!: From Academics to Zombies gathers together an irreverent group of scholars and writers to take a serious look at how zombies threaten almost every aspect of our lives. Spawned from the viral publication "When Zombies Attack!: Mathematical Modelling of an Outbreak of Zombie Infection," this multidisciplinary book draws on a variety of fields including biology, history, law, gender studies, archaeology, library science and landscape architecture. Part homage to zombie films and fiction, part cultural study, this collection humorously explores our deep-seated fear of the undead. Engaging and accessible, Braaaiiinnnnssss! will amuse academics and zombie fans alike. Publié en anglais.
A terrifying thriller that will crawl beneath your skin . . . and leave fresh blood on every page. “Fraught with tension . . . Invasion of the Body Snatchers meets The Hot Zone.”—Rocky Mountain News Across America a mysterious disease is turning ordinary people into raving, paranoid murderers who inflict brutal horrors on strangers, themselves, and even their own families. Working under the government’s shroud of secrecy, CIA operative Dew Phillips crisscrosses the country trying in vain to capture a live victim. With only decomposing corpses for clues, CDC epidemiologist Margaret Montoya races to analyze the science behind this deadly contagion. She discovers that these killers all have one thing in common—they’ve been contaminated by a bioengineered parasite, shaped by a complexity far beyond the limits of known science. Meanwhile Perry Dawsey—a hulking former football star now resigned to life as a cubicle-bound desk jockey—awakens one morning to find several mysterious welts growing on his body. Soon Perry finds himself acting and thinking strangely, hearing voices . . . he is infected. The fate of the human race may well depend on the bloody war Perry must wage with his own body, because the parasites want something from him, something that goes beyond mere murder.
On the surface, the zombie seems the polar opposite of the human--they are the living dead; we, in essence, are the dying alive. But the zombie is also "us." Although decaying, it looks like us, dresses like us, and sometimes (if rarely) acts like us. In this volume, essays by scholars from a range of disciplines examine the zombie as a thematic presence in literature, film, video games, legal language, and philosophy, exploring topics including zombies and the environment, litigation, the afterlife, capitalism, and the erotic. Through this wide-ranging examination of the zombie phenomenon, the authors seek to discover what the zombie can teach us about being human. Instructors considering this book for use in a course may request an examination copy here.
Rage is an unprecedented and intimate tour de force of new reporting on the Trump presidency facing a global pandemic, economic disaster and racial unrest. Woodward, the #1 international bestselling author of Fear: Trump in the White House, has uncovered the precise moment the president was warned that the Covid-19 epidemic would be the biggest national security threat to his presidency. In dramatic detail, Woodward takes readers into the Oval Office as Trump’s head pops up when he is told in January 2020 that the pandemic could reach the scale of the 1918 Spanish Flu that killed 675,000 Americans. In 17 on-the-record interviews with Woodward over seven volatile months—an utterly vivid window into Trump’s mind—the president provides a self-portrait that is part denial and part combative interchange mixed with surprising moments of doubt as he glimpses the perils in the presidency and what he calls the “dynamite behind every door.” At key decision points, Rage shows how Trump’s responses to the crises of 2020 were rooted in the instincts, habits and style he developed during his first three years as president. Revisiting the earliest days of the Trump presidency, Rage reveals how Secretary of Defense James Mattis, Secretary of State Rex Tillerson and Director of National Intelligence Dan Coats struggled to keep the country safe as the president dismantled any semblance of collegial national security decision making. Rage draws from hundreds of hours of interviews with firsthand witnesses as well as participants’ notes, emails, diaries, calendars and confidential documents. Woodward obtained 25 never-seen personal letters exchanged between Trump and North Korean leader Kim Jong Un, who describes the bond between the two leaders as out of a “fantasy film.” Trump insists to Woodward he will triumph over Covid-19 and the economic calamity. “Don’t worry about it, Bob. Okay?” Trump told the author in July. “Don’t worry about it. We’ll get to do another book. You’ll find I was right.”
