Analysis of Complex Disease Association Studies
Analysis of Complex Disease Association Studies

Author: Eleftheria Zeggini

Publisher: Academic Press

Published: 2010-11-17

Total Pages: 353

ISBN-13: 0123751438

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According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. - Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests - Extensive list of references including links to tutorial websites - Case studies and Tips and Tricks

Consanguinity in Context
Consanguinity in Context

Author: Alan H. Bittles

Publisher: Cambridge University Press

Published: 2012-05-24

Total Pages: 325

ISBN-13: 1107376939

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An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely comprehensive account of intra-familial marriage. Detailed information on past and present religious, social and legal practices and prohibitions is presented as a backdrop to the preferences and beliefs of the 1100+ million people in consanguineous unions. Chapters on population genetics, and the role of consanguinity in reproductive behaviour and genetic variation, set the scene for critical analyses of the influence of consanguinity on health in the early years of life. The discussion on consanguinity and disorders of adulthood is the first review of its kind and is particularly relevant given the ageing of the global population. Incest is treated as a separate issue, with historical and present-day examples examined. The final three chapters deal in detail with practical issues, including genetic testing, education and counselling, national and international legislation and imperatives, and the future of consanguineous marriage worldwide.

Encyclopedia of Biodiversity
Encyclopedia of Biodiversity

Author:

Publisher: Academic Press

Published: 2013-02-05

Total Pages: 5485

ISBN-13: 0123847206

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The 7-volume Encyclopedia of Biodiversity, Second Edition maintains the reputation of the highly regarded original, presenting the most current information available in this globally crucial area of research and study. It brings together the dimensions of biodiversity and examines both the services it provides and the measures to protect it. Major themes of the work include the evolution of biodiversity, systems for classifying and defining biodiversity, ecological patterns and theories of biodiversity, and an assessment of contemporary patterns and trends in biodiversity. The science of biodiversity has become the science of our future. It is an interdisciplinary field spanning areas of both physical and life sciences. Our awareness of the loss of biodiversity has brought a long overdue appreciation of the magnitude of this loss and a determination to develop the tools to protect our future. Second edition includes over 100 new articles and 226 updated articles covering this multidisciplinary field— from evolution to habits to economics, in 7 volumes The editors of this edition are all well respected, instantly recognizable academics operating at the top of their respective fields in biodiversity research; readers can be assured that they are reading material that has been meticulously checked and reviewed by experts Approximately 1,800 figures and 350 tables complement the text, and more than 3,000 glossary entries explain key terms

Encyclopedia of Rose Science
Encyclopedia of Rose Science

Author: Thomas Debener

Publisher: Academic Press

Published: 2003-10-27

Total Pages: 4142

ISBN-13: 0080917976

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The Encyclopedia of Rose Science brings together a wealth of information on the rose, long treasured for its captivating perfumes and splendid colors. Now, more than ever, science plays a central place in the production of this flower at the center of one of the world's biggest floricultural industries. A team of internationally renowned experts has contributed scores of articles, from the history of rose cultivation to discoveries in rose genetics. For researchers and students, as well as commercial rose growers and breeders, the Encyclopedia of Rose Science is an invaluable reference. The Encyclopedia of Rose Science is available online on ScienceDirect. The print edition price for this reference work does not include online access. For more information on pricing for access to the online edition, please review our Licensing Options. The richness and authority of Elsevier reference works is now lent valuable functionality and accessibility through the online launch of Elsevier Reference Works on ScienceDirect. Features: Extensive browsing and searching across subject, thematic, alphabetical, author and cited author indexes - as applicable to the work Basic and advanced search functionality within volumes, parts of volumes, or across the whole work Ability to build, save and re-run searches as well as combine saved searches Internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy All articles are available as full-text HTML files, and as PDF files that can be viewed, downloaded or printed out in their original print format A dedicated Reference Works navigation tab and homepage on ScienceDirect to enable easy linking from your OPAC or library website For more information about the Elsevier Reference Works on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/reference_works. Presents complete, up-to-date information on over 35 subject areas of major importance to rose scientists Encyclopedic format provides for concise, readable entires, easy searches, and extensive cross-references Incorporates MODERN ROSES XI, published by the American Rose Society as International Cultivar Registration Authority for Roses, the most comprehensive list of roses of historical and botanical importance! High quality full-color production, with many figures and tables

Behaviour, Development and Evolution
Behaviour, Development and Evolution

Author: Patrick Bateson

Publisher: Open Book Publishers

Published: 2017-02-20

Total Pages: 125

ISBN-13: 1783742518

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The role of parents in shaping the characters of their children, the causes of violence and crime, and the roots of personal unhappiness are central to humanity. Like so many fundamental questions about human existence, these issues all relate to behavioural development. In this lucid and accessible book, eminent biologist Professor Sir Patrick Bateson suggests that the nature/nurture dichotomy we often use to think about questions of development in both humans and animals is misleading. Instead, he argues that we should pay attention to whole systems, rather than to simple causes, when trying to understand the complexity of development. In his wide-ranging approach Bateson discusses why so much behaviour appears to be well-designed. He explores issues such as ‘imprinting’ and its importance to the attachment of offspring to their parents; the mutual benefits that characterise communication between parent and offspring; the importance of play in learning how to choose and control the optimal conditions in which to thrive; and the vital function of adaptability in the interplay between development and evolution. Bateson disputes the idea that a simple link can be found between genetics and behaviour. What an individual human or animal does in its life depends on the reciprocal nature of its relationships with the world about it. This knowledge also points to ways in which an animal’s own behaviour can provide the variation that influences the subsequent course of evolution. This has relevance not only for our scientific approaches to the systems of development and evolution, but also on how humans change institutional rules that have become dysfunctional, or design public health measures when mismatches occur between themselves and their environments. It affects how we think about ourselves and our own capacity for change.

Inbreeding, Incest, and the Incest Taboo
Inbreeding, Incest, and the Incest Taboo

Author: Arthur P. Wolf

Publisher: Stanford University Press

Published: 2005

Total Pages: 240

ISBN-13: 0804751412

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Why is incest widely prohibited? Why does the scope of the prohibition vary from society to society? Why does incest occur despite the prohibition? What are the consequences? To reexamine these questions, this book brings together contributions from the fields of genetics, behavioral biology, primatology, biological and social anthropology, philosophy, and psychiatry.

Inbreeding and Brood Stock Management
Inbreeding and Brood Stock Management

Author: Douglas Tave

Publisher: Food & Agriculture Org.

Published: 1999

Total Pages: 138

ISBN-13: 9789251043400

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A manual dealing primarily with the problems caused by unwanted inbreeding in cultured fish populations, describing management techniques for preventing or minimising inbreeding, and also how inbreeding can be used to improve captive populations of fish

Animal Biotechnology
Animal Biotechnology

Author: Ashish S. Verma

Publisher: Academic Press

Published: 2013-11-04

Total Pages: 685

ISBN-13: 0123914345

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Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field.Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. - Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases - Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering

Introduction to Conservation Genetics
Introduction to Conservation Genetics

Author: Richard Frankham

Publisher: Cambridge University Press

Published: 2010

Total Pages: 643

ISBN-13: 0521878470

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This impressive author team brings the wealth of advances in conservation genetics into the new edition of this introductory text, including new chapters on population genomics and genetic issues in introduced and invasive species. They continue the strong learning features for students - main points in the margin, chapter summaries, vital support with the mathematics, and further reading - and now guide the reader to software and databases. Many new references reflect the expansion of this field. With examples from mammals, birds ...

Introduction to Theoretical Population Genetics
Introduction to Theoretical Population Genetics

Author: Thomas Nagylaki

Publisher: Springer Science & Business Media

Published: 2013-03-12

Total Pages: 381

ISBN-13: 364276214X

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This book covers those areas of theoretical population genetics that can be investigated rigorously by elementary mathematical methods. I have tried to formulate the various models fairly generally and to state the biological as sumptions quite explicitly. I hope the choice and treatment of topics will en able the reader to understand and evaluate detailed analyses of many specific models and applications in the literature. Models in population genetics are highly idealized, often even over idealized, and their connection with observation is frequently remote. Further more, it is not practicable to measure the parameters and variables in these models with high accuracy. These regrettable circumstances amply justify the use of appropriate, lucid, and rigorous approximations in the analysis of our models, and such approximations are often illuminating even when exact solu tions are available. However, our empirical and theoretical limitations justify neither opaque, incomplete formulations nor unconvincing, inadequate analy ses, for these may produce uninterpretable, misleading, or erroneous results. Intuition is a principal source of ideas for the construction and investigation of models, but it can replace neither clear formulation nor careful analysis. Fisher (1930; 1958, pp. x, 23-24, 38) not only espoused similar ideas, but he recognized also that our concepts of intuition and rigor must evolve in time. The book is neither a review of the literature nor a compendium of results. The material is almost entirely self-contained. The first eight chapters are a thoroughly revised and greatly extended version of my published lecture notes (Nagylaki, 1977a).