Diabetes Mellitus in Children
Author: Mark A. Sperling
Publisher:
Published: 2005
Total Pages: 0
ISBN-13: 9781416027539
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Diabetes Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment
Author: Enzo Bonora
Publisher: Springer
Published: 2018-10-23
Total Pages: 0
ISBN-13: 9783319450148
DOWNLOAD EBOOKThis book provides the reader with comprehensive information on the epidemiology, etiology, pathogenesis, pathophysiology, clinical features, prevention, and treatment of diabetes with the aim of empowering health care providers in their daily battle against the disease. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book, combining basic science with a practical clinical orientation, will be of value for all physicians and nurses who care for patients with diabetes.
International Textbook of Diabetes Mellitus
Author: R. A. DeFronzo
Publisher: John Wiley & Sons
Published: 2015-03-11
Total Pages: 1200
ISBN-13: 1118387678
DOWNLOAD EBOOKThe International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Molecular Nutrition and Diabetes
Author: Didac Mauricio
Publisher: Academic Press
Published: 2015-12-08
Total Pages: 400
ISBN-13: 0128017619
DOWNLOAD EBOOKMolecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes. - Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitus - Explores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complications - Investigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition
Diabetes Mellitus
Author: Derek LeRoith
Publisher: Lippincott Williams & Wilkins
Published: 2004
Total Pages: 1608
ISBN-13: 9780781740975
DOWNLOAD EBOOKThoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.
CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Author: B. Kyewski
Publisher: Springer Science & Business Media
Published: 2006-01-09
Total Pages: 331
ISBN-13: 3540277021
DOWNLOAD EBOOKThe vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
The Genetic Landscape of Diabetes
Author: Laura Dean
Publisher:
Published: 2004
Total Pages:
ISBN-13:
DOWNLOAD EBOOKType I Diabetes
Author: George S. Eisenbarth
Publisher:
Published: 1996
Total Pages: 328
ISBN-13:
DOWNLOAD EBOOKType I diabetes is rapidly becoming one of the most studied autoimmune disorders. The existence of two spontaneous animal models, transgenic models which both create or suppress disease, coupled with the clinical importance of the illness with millions affected and thousands killed each year, has led to enormous efforts by an international groups of investigators to understand, treat and prevent type I diabetes. This timely new book presents a synthesis of the molecular and cellular immunology of type I diabetes by basic immunologists and physician investigators at the Barbara Davis Center for Childhood Diabetes. At this center, T cell clones able to produce diabetes were discovered, the first antigen with which they react characterized, combinatorial, biochemical autoantibody screening for diabetes risk was recently published and multiple trials for the prevention of type I diabetes were carried out. This volume discusses the latest research in this rapidly developing field, including diagnostic strategies and therapies being developed to prevent this disease.
Textbook of Diabetes
Author: Richard I. G. Holt
Publisher: John Wiley & Sons
Published: 2017-03-06
Total Pages: 1104
ISBN-13: 1118912020
DOWNLOAD EBOOKNow in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.
Immunotherapy of Type 1 Diabetes
Author: Domenico Andreani
Publisher: John Wiley & Sons
Published: 1989
Total Pages: 280
ISBN-13:
DOWNLOAD EBOOKRecent national, European and international diabetes meetings have seen controversial discussions on the potential benefit and also on ethical aspects of immune intervention in patients with Type 1 diabetes or in persons with a high risk of developing the disease.
