Immunoendocrinology: Scientific and Clinical Aspects
Immunoendocrinology: Scientific and Clinical Aspects

Author: George S. Eisenbarth

Publisher: Springer Science & Business Media

Published: 2010-12-13

Total Pages: 573

ISBN-13: 1603274782

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Immunoendocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems. Immunoendocrinology: Scientific and Clinical Aspects explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. Chapters cover both basic pathophysiology informed by studies of animal models as well as current understanding of multiple related clinical diseases—their pathophysiology, diagnosis, and therapy. Immunoendocrinology: Scientific and Clinical Aspects captures the central role of immunoendocrinologic processes in the pathogenesis of not only type 1 diabetes but in a range of other autoimmune and endocrine disorders.

Immunopathology in Toxicology and Drug Development
Immunopathology in Toxicology and Drug Development

Author: George A. Parker

Publisher: Springer

Published: 2017-03-27

Total Pages: 834

ISBN-13: 3319473859

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This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Endocrine Immunology
Endocrine Immunology

Author: W. Savino

Publisher: Karger Medical and Scientific Publishers

Published: 2017-02-28

Total Pages: 190

ISBN-13: 3318060143

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In the last decades, several in vitro and in vivo studies have revealed the existence of a very complex network between the neuroendocrine and immune system. Important molecular mechanisms underlying these interactions, in both physiological and pathological conditions, have also been described. Indeed, hormones play a pivotal role in the development and functional regulation of the immune system – both innate and acquired responses. Immune system cells present specific hormone receptors and themselves produce some hormones, thus influencing hormone secretion. More recently, the modulation of hormone secretion has been attempted for treating associated autoimmune disorders, further supporting the strong interplay between the endocrine and immune system. Distinguished experts, who have published extensively in their fields, have contributed comprehensive chapters to this volume. The focus is on the various aspects of endocrine-neuro-immune connections, providing an updated panorama - from basics to clinical applications - of current knowledge and still debated issues.

Physiologic Autoimmunity and Preventive Medicine
Physiologic Autoimmunity and Preventive Medicine

Author: Alexander B. Poletaev

Publisher: Bentham Science Publishers

Published: 2013-06-03

Total Pages: 254

ISBN-13: 1608057240

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The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. A considerable number of immune functions, including those related to antimicrobial defense, derive from autoclearance as well as construction and support of multicellularity. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonins), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the affected organ. Secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. Experimental and clinical production antibodies reveal antibodies against nuclear antigens, which penetrate into living cell nuclei and alter nuclear acid synthesis, cell proliferation and function. Autoantibodies can thus be regarded as hormone-like bioregulators of gene expression. The immune system is apparently able to reproduce complementary regulators for various cell receptors, including nuclear ones. The book focuses on physiological autoimmunity models and delves into the relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The E-book is a unique and comprehensive monograph and includes a history and contemporary research on natural autoimmunity - a fundamental concept essential for many branches of medicine and pathology. The concepts described in this e-book also have broad practical implications for the healthcare sector, because it establishes effective method of early prediction for many different diseases and creates a basis for prophylaxis. The reference gives medical and clinical professionals a chance to revisit old dogmas and acquire fruitful perspectives for theoretical reasoning and research planning.

Celiac Disease and Gluten
Celiac Disease and Gluten

Author: Peter Koehler

Publisher: Academic Press

Published: 2014-06-05

Total Pages: 273

ISBN-13: 0127999264

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Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities is a unique reference work—the first to integrate the insights of the causes and effects of celiac disease from the chemistry of reaction-causing foods to the diagnosis, pathogenesis, and symptoms that lead to proper diagnoses and treatment. With an estimated three million people in the United States alone affected by celiac disease, an autoimmune digestive disease, only five percent are properly diagnosed. Drawing on the connection between foods containing gluten and the resulting symptoms, this resource offers distinctive information that directly explores and links food science, medical diagnostics, and treatment information. A helpful tool for researchers and medical practitioners alike, Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities helps refine research targets, and provides a comprehensive overview on the multidisciplinary approaches to all crucial aspects related to celiac disease. - Presents key information from medical and food science research, as well as provides clinical insights - Provides direct corollary insights between source and symptom - Written by experts whose detailed experiments and results have shaped our understanding of celiac disease

The Autoimmune Diseases
The Autoimmune Diseases

Author: M. Eric Gershwin

Publisher: Academic Press

Published: 2019-10-15

Total Pages: 1534

ISBN-13: 0128122420

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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P's" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. - Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy - Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases - Keeps readers abreast of current trends and emerging areas in the field - Ensures that content is not only up-to-date, but applicable and relevant - Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Reproductive Immunology
Reproductive Immunology

Author: Gil Mor

Publisher: Academic Press

Published: 2021-02-12

Total Pages: 462

ISBN-13: 0128189304

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Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs. - Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus - Evaluates each immune cell type and its function during specific reproductive events - Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series

NeuroPsychopharmacotherapy
NeuroPsychopharmacotherapy

Author: Peter Riederer

Publisher: Springer Nature

Published: 2022-11-04

Total Pages: 4652

ISBN-13: 303062059X

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This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.

Author's Handbook of Styles for Life Science Journals
Author's Handbook of Styles for Life Science Journals

Author: Michel Atlas

Publisher: CRC Press

Published: 1995-11-08

Total Pages: 712

ISBN-13: 9780849325038

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Let the Author's Handbook of Styles for Life Science Journals save you time and trouble by providing a one-stop resource for all your manuscript writing requirements. No more plowing through your journal collection or wandering the library stacks to get those elusive journal pages containing instructions to authors. This unique book contains all the information you need to know: whether the journal will consider your manuscript; the journal's submission address; how to construct the abstract, illustrations, tables, and references; and specific information on copyright, multiple authorship, statistical analyses, and page charges. The Author's Handbook of Styles for Life Science Journals gives all this information for 440 of the most important English-language, life science journals. Titles were selected from the "Journal Rankings by Times Cited" list in the Science Citation Index Journal Citation Report. Because this report is heavily weighted toward the medical sciences, other life science journals are incorporated into the book based on general level of prestige and reputation. In addition, some new titles that promise to be important to their fields, like Nature Medicine and Emerging Infectious Diseases are also included. Organized by journal title, the handbook's entries are uniformly arranged to allow direct comparison between journals. Information is presented in an easy-to-use, easy-to-read format with clear and explicitly stated instructions. The Author's Handbook of Styles for Life Science Journals gives authors in the life sciences all the information necessary for the correct and complete compilation of a manuscript for submission to their journal of choice.