Therapeutic Implications of Circadian Rhythms

Therapeutic Implications of Circadian Rhythms

Author: Guangrui Yang

Publisher: Frontiers Media SA

Published: 2015-10-12

Total Pages: 98

ISBN-13: 2889196658

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Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms


Bring That Beat Back

Bring That Beat Back

Author: Nate Patrin

Publisher: U of Minnesota Press

Published: 2020-06-09

Total Pages: 336

ISBN-13: 1452963800

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How sampling remade hip-hop over forty years, from pioneering superstar Grandmaster Flash through crate-digging preservationist and innovator Madlib Sampling—incorporating found sound and manipulating it into another form entirely—has done more than any musical movement in the twentieth century to maintain a continuum of popular music as a living document and, in the process, has become one of the most successful (and commercial) strains of postmodern art. Bring That Beat Back traces the development of this transformative pop-cultural practice from its origins in the turntable-manning, record-spinning hip-hop DJs of 1970s New York through forty years of musical innovation and reinvention. Nate Patrin tells the story of how sampling built hip-hop through the lens of four pivotal artists: Grandmaster Flash as the popular face of the music’s DJ-born beginnings; Prince Paul as an early champion of sampling’s potential to elaborate on and rewrite music history; Dr. Dre as the superstar who personified the rise of a stylistically distinct regional sound while blurring the lines between sampling and composition; and Madlib as the underground experimentalist and record-collector antiquarian who constantly broke the rules of what the mainstream expected from hip-hop. From these four artists’ histories, and the stories of the people who collaborated, competed, and evolved with them, Patrin crafts a deeply informed, eminently readable account of a facet of pop music as complex as it is commonly underestimated: the aesthetic and reconstructive power of one of the most revelatory forms of popular culture to emerge from postwar twentieth-century America. And you can nod your head to it.


Rhythm Science

Rhythm Science

Author: Paul D. Miller

Publisher: MIT Press

Published: 2004-03-19

Total Pages: 67

ISBN-13: 026263287X

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The art of the mix creates a new language of creativity. "Once you get into the flow of things, you're always haunted by the way that things could have turned out. This outcome, that conclusion. You get my drift. The uncertainty is what holds the story together, and that's what I'm going to talk about."—Rhythm Science The conceptual artist Paul Miller, also known as Dj Spooky that Subliminal Kid, delivers a manifesto for rhythm science—the creation of art from the flow of patterns in sound and culture, "the changing same." Taking the Dj's mix as template, he describes how the artist, navigating the innumerable ways to arrange the mix of cultural ideas and objects that bombard us, uses technology and art to create something new and expressive and endlessly variable. Technology provides the method and model; information on the web, like the elements of a mix, doesn't stay in one place. And technology is the medium, bridging the artist's consciousness and the outside world. Miller constructed his Dj Spooky persona ("spooky" from the eerie sounds of hip-hop, techno, ambient, and the other music that he plays) as a conceptual art project, but then came to see it as the opportunity for "coding a generative syntax for new languages of creativity." For example: "Start with the inspiration of George Herriman's Krazy Kat comic strip. Make a track invoking his absurd landscapes...What do tons and tons of air pressure moving in the atmosphere sound like? Make music that acts a metaphor for that kind of immersion or density." Or, for an online "remix" of two works by Marcel Duchamp: "I took a lot of his material written on music and flipped it into a DJ mix of his visual material—with him rhyming!" Tracing the genealogy of rhythm science, Miller cites sources and influences as varied as Ralph Waldo Emerson ("all minds quote"), Grandmaster Flash, W. E. B Dubois, James Joyce, and Eminem. "The story unfolds while the fragments coalesce," he writes. Miller's textual provocations are designed for maximum visual and tactile seduction by the international studio COMA (Cornelia Blatter and Marcel Hermans). They sustain the book's motifs of recontextualizing and relayering, texts and images bleed through from page to page, creating what amount to 2.5 dimensional vectors. From its remarkable velvet flesh cover, to the die cut hole through the center of the book, which reveals the colored nub holding in place the included audio CD, Rhythm Science: Excerpts and Allegories from the Sub Rosa Archives, this pamphlet truly lives up to Editorial Director Peter Lunenfeld's claim that the Mediawork Pamphlets are "theoretical fetish objects...'zines for grown-ups."


The Ultimate Icebreaker and Teambuilder Guide

The Ultimate Icebreaker and Teambuilder Guide

Author: Jon Tucker

Publisher: Lulu.com

Published: 2007

Total Pages: 290

ISBN-13: 1430306939

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The Ultimate Icebreaker and Teambuilder Guide offers over 200 different activities for you to use in a variety of contexts! If you are looking for a 5-minute warm up activity or you are building a team, there are exercises to meet your every need. Built upon practice in higher education, this book provides countless options for the business world, nonprofits, education or high school environments. Easily indexed and offering facilitation questions, this book will help you energize and organize your group!


体育英语

体育英语

Author:

Publisher: 清华大学出版社有限公司

Published: 2004

Total Pages: 280

ISBN-13: 9787302089278

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CCTV-5中央电视台体育节目中心体育英语教学节目清华经管


Boitano's Edge

Boitano's Edge

Author: Brian Boitano

Publisher: Simon and Schuster

Published: 1997-12

Total Pages: 151

ISBN-13: 0689819153

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Olympic ice skating champion Brian Boitano describes the sport of figure skating and his own experiences as a skater.


Studies

Studies

Author: Rockefeller Institute for Medical Research

Publisher:

Published: 1913

Total Pages: 704

ISBN-13:

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Energy and Rhythm

Energy and Rhythm

Author: Gordon Walker

Publisher: Rowman & Littlefield

Published: 2021-04-07

Total Pages: 239

ISBN-13: 1786613360

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Rhythms animate our lives and the worlds we inhabit. Rhythms of getting things done, of working technologies, of day and night and the seasons, and of shared patterns of work, home-life and moving around. Rhythms are also intrinsically about flows of energy – heat, light, motion – from the smallest movements of muscles, to the petrol-fuelled rhythms of the rush hour, the spinning of wind turbines and shifting cycles of solar radiation. This book sets out to energise Lefebvre’s rhythmanalysis in order to develop a novel and far reaching polyrhythmic conceptualisation of the beats and pulses of our relations with energy in both its natural and technological forms. Social theory, thermodynamic thinking and diverse streams of energy-oriented research are brought together to trace how the climate crisis has the rhythmic patterning of big power energy systems at its core; and how transitioning to a just, low carbon future means transforming energy systems and our everyday dependencies on them into new rhythmic patterns and interrelations.


Almost Us

Almost Us

Author: William H. Calvin

Publisher: William H. Calvin

Published: 2010-08-09

Total Pages: 648

ISBN-13: 0982916701

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Ghostly Campfire Stories of Western Canada

Ghostly Campfire Stories of Western Canada

Author: Barbara Smith

Publisher: Heritage House Publishing Co

Published: 2018-05-11

Total Pages: 112

ISBN-13: 1772032468

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Hair-raising tales of ghosts, spirits, and unexplained phenomena set across Western Canada. Praise for Campfire Stories of Western Canada: “Smith’s spooky tales are perfect for warm summer nights spent around the campfire. Her latest book of ghost stories focuses solely on Western Canada and is a wonderful fit for families looking for fun and spooky tales to tell under the stars.”—Quirk Magazine In this delightful companion to the bestselling Campfire Stories of Western Canada, Barbara Smith scours the spookiest corners of local folklore from Vancouver Island to the Canadian Rockies to the vast plains of the Prairies to bring readers a brand-new collection of ghost stories. Combining truth, legend, and a healthy dose of suspense, Smith weaves together over thirty bone-chilling tales perfectly suited for reading aloud on family camping trips or quiet nights at home. Suitable for ages eight to eighty-eight, this frighteningly fun collection reveals the supernatural side of Western Canada.