Host-pathogen Interactions in Mycobacterium Tuberculosis Infection of Airway Epithelial Cells
Author: Stacey-Ann Lee Wanpei
Publisher:
Published: 2022
Total Pages:
ISBN-13:
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Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions
Author: Seyed Ehtesham Hasnain
Publisher: Springer Nature
Published: 2019-11-30
Total Pages: 524
ISBN-13: 9813294132
DOWNLOAD EBOOKThis book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.
Study of Host Pathogen Interactions Using a Model of Pseudomonas Aeruginosa Infection of Lung Epithelial Cells
Author: Rebecca Jean Barnes
Publisher:
Published: 2008
Total Pages: 358
ISBN-13:
DOWNLOAD EBOOK"Pseudomonas aeruginosa is an opportunistic pulmonary pathogen that can cause acute, life-threatening pneumonia in immunocompromised individuals, it is a common cause of high-mortality ventilator associated pneumonia, and frequently colonizes the lungs of cystic fibrosis patients. As an opportunist, P. aeruginosa uses multiple strategies to exploit host cells during pulmonary infections, and many of these mechanisms are not completely understood. The goal of this study was to develop and optimize a set of experimental methods that would allow us to explore the host-pathogen interactions between P. aeruginosa and lung epithelial cells, and to use these methods to specifically investigate the role of lung epithelial integrin receptors in P. aeruginosa pathogenesis ....
Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism
Author: Jean Pieters
Publisher: Springer Science & Business Media
Published: 2013-12-09
Total Pages: 248
ISBN-13: 3642402321
DOWNLOAD EBOOKMycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
Systems Biology of Tuberculosis
Author: Johnjoe McFadden
Publisher: Springer Science & Business Media
Published: 2012-12-09
Total Pages: 238
ISBN-13: 1461449669
DOWNLOAD EBOOKThe book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.
Molecular Biology of the Cell
Author:
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
DOWNLOAD EBOOKESX-1: A Novel Alternative Secretion System in Mycobacterium Tuberculosis that Mediates the Host-pathogen Interaction
Author: Sarah A. Stanley
Publisher:
Published: 2006
Total Pages: 318
ISBN-13:
DOWNLOAD EBOOKMycobacterium tuberculosis is one of the world's most successful pathogens, infecting approximately one-third of humanity. This remarkable bacterium has infected human beings for millennia, and has evolved mechanisms for the manipulation of host biology to create an optimal environment for bacterial survival and growth. Here we describe the identification and characterization of ESX-1, the first alternative secretion system identified in M. tuberculosis, and show its fundamental importance for virulence. We have identified three genes, Rv3870, Rv3871, and Rv3877, that encode components of the ESX-1 secretion system, which functions to secrete ESAT-6 and CFP-10, proteins with dual functions as immunodominant antigens and virulence factors. Components and substrates of ESX-1 are required for full virulence of M. tuberculosis in both mice and macrophages. The ESX-1 secretion system functions to subvert host cell biology, and is required for the suppression of Interleukin-12 (IL-12) and Tumor Necrosis Factor-alpha (TNF-alpha). ESX-1 is also required for the induction, both in vivo and in vitro, of type I Interferons (IFNs), cytokines usually associated with an anti-viral immune response. We show that the induction of type I IFNs may be a pathogenic strategy that enhances virulence of M. tuberculosis. We also examine the role of the ESAT-6 and CFP-10 in the protective immune response in M. tuberculosis. We find that restoration of a functional ESX-1 system to the live attenuated vaccine strain mycobacterium Bacille Calmette-Guerin results in an increase in immunogenicity of this strain, which may lead to the development of more a more effective vaccine. These studies identify ESX-1 mediated secretion of ESAT-6 and CFP-10 to one of the most important pathways identified in M. tuberculosis, both for virulence of the organism and for induction of the protective immune response to infection, and begin to describe the mechanisms by which ESX-1 secretion regulates host biology and the outcome of infection.
Host Pathogen Interaction During Streptococcus Pneumoniae Infection of Lung Epithelial Cells
Author: Björn Klabunde
Publisher:
Published: 2023
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOKSARS, MERS and other Viral Lung Infections
Author: David S. Hui
Publisher: European Respiratory Society
Published: 2016-06-01
Total Pages: 148
ISBN-13: 1849840709
DOWNLOAD EBOOKViral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Neurobiology of Respiration
Author: Mieczyslaw Pokorski
Publisher: Springer Science & Business Media
Published: 2013-07-08
Total Pages: 427
ISBN-13: 9400766270
DOWNLOAD EBOOKRespiration is an area of the medical study that undergoes fast developments. A better understanding of the neural and cellular mechanisms underlying respiratory disorders and lung function is essential for the evidence-based pharmacotherapy and for optimizing the patient care and prophylactic measures to improve the health and quality of life. This comprehensive book is a blend of basic and clinical research. The book is thought to promote the translation of science into clinical practice. The book presents an update on the areas of current research and clinical interest in the neurobiology of the respiratory system. Recent innovations in detection and management of respiratory diseases are described. The book will be a base of reference in the field of respiration for years to come and a source of future research ideas. This book is a required text for respiratory scientists, neuropathologists, and for clinicians searching for ‘bench to bedside’ treatments of lung diseases.
