Hormone Receptors in Breast Cancer
Hormone Receptors in Breast Cancer

Author: Suzanne A. W. Fuqua

Publisher: Springer Science & Business Media

Published: 2008-12-10

Total Pages: 289

ISBN-13: 0387094636

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Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Clinical Interest of Steroid Hormone Receptors in Breast Cancer
Clinical Interest of Steroid Hormone Receptors in Breast Cancer

Author: G. Leclercq

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 381

ISBN-13: 364282188X

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Several papers dealing with the clinical relevance of steroid hormone receptors in breast cancer have already been published. However, no publication has overviewed studies currently being conducted in Europe, nor is there a register of the european centers performing receptor assays. It has been our purpose to fill these gaps. A large majority of authors who we contacted kindly agreed to con tribute to our book. Papers were grouped into six main parts according to their contents. The abundance of clinical data relevant to receptor assays led us to add critical summaries to help the reader to form his own opinions on the subject. We would like to thank Drs. R. J. B. King, G. Contesso, L. Santi, and E. Engelsman, who helped us in this regard. We hope that this book will enable the reader to become acquainted with the present state of European steroid hormone receptor studies devoted to breast cancer treatment. We also hope that it will promote cooperation between European oncologists involved in this field of research.

Hormone Receptors in Breast Cancer
Hormone Receptors in Breast Cancer

Author: Suzanne A. W. Fuqua

Publisher: Springer

Published: 2008-11-01

Total Pages: 0

ISBN-13: 9780387560380

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Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Hormone Receptors in Breast Cancer
Hormone Receptors in Breast Cancer

Author: Suzanne A. W. Fuqua

Publisher: Springer

Published: 2014-10-20

Total Pages: 0

ISBN-13: 9781489996800

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Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Estrogens, Estrogen Receptor and Breast Cancer
Estrogens, Estrogen Receptor and Breast Cancer

Author: Fritz F. Parl

Publisher: IOS Press

Published: 2000

Total Pages: 280

ISBN-13: 9780967335544

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Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.

The Heterogeneity of Cancer Metabolism
The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Hormone Receptors in Breast Cancer Prognosis - Racial and Quantitative Effects
Hormone Receptors in Breast Cancer Prognosis - Racial and Quantitative Effects

Author:

Publisher:

Published: 2001

Total Pages: 0

ISBN-13:

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Breast cancer survivors compose the largest group of cancer survivors in the United States. As heterogeneity exists within stages and between races in breast cancer survival, it is important to develop a better understanding of prognostic factors. Tumor estrogen and progesterone receptors are one of the more important prognostic factors in breast cancer patients. However, currently in clinical practice hormone receptor status is treated as either being present or absent and is treated similarly in all groups. The dichotomization of hormone status may lead to loss of valuable information and hormone receptor status may not have the same effect in African Americans and Whites. This historical cohort study evaluates quantitative differences in tumor hormone receptors in African Americans and Whites and determines whether survival effects differ between the two groups. This study also assesses whether a dose-response relationship, linear or nonlinear, exists between hormone receptors and survival. Findings of this study may lead to better prediction of survival and to identification of subsets of patients at higher risk that may have gone unrecognized by the application of a single cutpoint. Our preliminary findings indicate that African American breast cancer patients have more estrogen receptor negativity and a worse survival.

Sex Hormone Receptor Signals in Human Malignancies
Sex Hormone Receptor Signals in Human Malignancies

Author: Hiroshi Miyamoto

Publisher: MDPI

Published: 2019-10-01

Total Pages: 150

ISBN-13: 3039211730

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Sex steroids, including androgens, estrogens, and progestogens, are known to have widespread physiological actions beyond the reproductive system via binding to the sex hormone receptors. Meanwhile, emerging evidence has indicated that sex hormone receptor signals are involved in the outgrowth of some malignancies, such as prostate and breast carcinomas, as well as others that have not traditionally been considered as endocrine-related neoplasms. This Special Issue “Sex Hormone Receptor Signals in Human Malignancies” covers various aspects of the potential role of sex hormone receptors and related signals in prostate cancer, breast cancer, and other neoplastic conditions by depicting promising findings derived from in vitro and in vivo experiments as well as the analyses of surgical specimens. The current observations described may thus provide a unique insight into novel or known functions of sex hormone receptors and related molecules.

The New Testosterone Treatment
The New Testosterone Treatment

Author: Edward Friedman

Publisher: Rowman & Littlefield

Published: 2023-12-21

Total Pages: 388

ISBN-13: 1493083678

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Written by the leading authority on hormone receptors and prostate cancer, this book reveals the surprising truth about how you can prevent and treat breast cancer, prostate cancer, and Alzheimer's with testosterone and other FDA-approved drugs.For decades, doctors have sought to combat prostate cancer under the mistaken assumption that testosterone fueled its growth. But the latest research into the nature of hormone receptors and therapies using bioidentical instead of synthetic hormones have caused a shift in thinking and new hope for treating this cancer with testosterone. Today the medical profession equates a diagnosis of Alzheimer's with a death sentence. In fact, the only thing doctors do is throw ineffective drugs at it and resign themselves to failure. For the first time, this book explains how testosterone can halt the disease and cure early-stage Alzheimer's. Similar breakthroughs for fighting breast cancer follow close on the heels of these revelations, outlining how the avoidance of synthetic progestins and the use of aromatase inhibitors are crucial tools in prevention and treatment. At the core of this book is the remarkable observation that we experience our highest hormone levels during our teen years--a time of life when there is no breast cancer, prostate cancer, or Alzheimer's. Could bringing hormones back to teen levels be the key to vibrant good health? The answer is a resounding yes. This thoroughly researched guide to the latest biomedical research is must-reading for medical professionals and anyone concerned about their health.