Lipids and Lipidoses
Lipids and Lipidoses

Author: G. Schettler

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 637

ISBN-13: 3642873677

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Advances which have been made in the field of lipid chemistry and bio chemistry during the last ten years mainly are the results of progress in metho dology. The introduction of isotopic and chromatographic techniques has not only enriched our knowledge of normal lipid metabolism but has also greatly enhanced the understanding of the various lipidoses. This is well illustrated by a comparison of the contents of the present monograph with those of my 1955 review in Handbuch der Inneren Medizin (Springer). In addition to better information about the classic lipid thesaurismoses Nie mann-Pick disease, Gaucher's disease and Tay-Sachs disease, the number of hereditary lipid storage diseases has increased considerably through the recogni tion of new syndromes such as metachromatic leukodystrophy, Fabry's disease, Refsum's disease (heredopathia atactica polyneuritiformis), a-p-lipoproteinemia, and Tangier disease. Conversely, disorders such as Hand-Scholler-Christian disease which has been considered a lipidosis up to 1958 (THANNHAUSER) must now be differentiated from the hereditary disturbances of lipid metabolism. Essential hyperlipemia which at one time seemed to be a well defined entity has now been recognized to consist of a number of subgroups, whose pathogeneses appear to be quite different, and whose classification is by no means definite. Similar problems exist for "essential hypercholesterolemia". Since the knowledge of today is the key for the solutions of tomorrow, we are fortunate that the chapters on lipidoses are supplemented by a comprehensive account of lipid chemistry and biochemistry which has been coordinated by W. STOFFEL.

A History of Gastric Secretion and Digestion
A History of Gastric Secretion and Digestion

Author: Horace W Davenport

Publisher: Springer

Published: 2013-05-27

Total Pages: 426

ISBN-13: 146147602X

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For centuries men speculated about the process of gastric digestion, but Iate in the eighteenth and early in the nineteenth centuries physiologists, both physicians and laymen, began to accumulate experimental evidence about its nature. At the same time, others discovered that the stomach is capable of secreting a strong mineral acid, and the questions of how that secretion is produced and how it is controlled became enduring problems. A Iittle later, the discovery that an acid extract of dead gastric mucosa is capable of digesting meat put the study of gastric secretion and digestion on a firm mechanistic foundation. From that time to the present, physi ologists have assiduously investigated gastric secretion and digestion, with the result that knowledge ofthose topics is as comprehensive and penetrating as isthat about other physiological processes. In addition, that knowledge is the basis of discrimi nating and effective clinical practice. I have described the experimental study of gastric secretion and digestion for two reasons. The firstisthat the successes and some ofthe failures ofphysiologists over two centuries are important parts of intellectual history that deserve to be recorded. The second is that some of those who use the accumulated knowledge every day are curious about its genesis. I assume that my readers have the technical knowledge to understand what I have written. If my account does not fully satisfy their curiosity, I have provided references that will open the path to further study.

Methods of Enzymatic Analysis V2
Methods of Enzymatic Analysis V2

Author: Hans-UIrich Bergmeyer

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 640

ISBN-13: 0323161375

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Methods of Enzymatic Analysis, Volume 2 reviews developments in the determination of enzyme activity, including advances in assay techniques. It discusses the principles on which measurements of enzymes are based, with each chapter including equations and each method consisting of the pipetting protocol. This volume is divided into four parts, each discussing a group of enzymes and their determination. Part I focuses on oxidoreductases, such as sorbitol dehydrogenase, lactate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, 6-phosphogluconate dehydrogenase, xanthine oxidase, and glutamate dehydrogenase. Part II is concerned with transferases ranging from ornithine carbamoyltransferase and transamidinase to transketolase, transaldolase, UDP-glucuronyltransferase, glutamate-pyruvate transaminase, and phosphotransferases. Part III discusses hydrolases including esterases, glycoside hydrolases, peptidases, and proteinases, whereas Part IV looks at lyases, isomerases, and ligases, such as fructose-1, 6-diphosphate aldolase, 1-phosphofructoaldolase, glucosephosphate isomerase, and tetrahydrofolate formylase. This book is a valuable resource for biochemists as well as students and researchers working in the field of analytical biochemistry.