High-Performance In-Memory Genome Data Analysis
High-Performance In-Memory Genome Data Analysis

Author: Hasso Plattner

Publisher: Springer Science & Business Media

Published: 2013-11-19

Total Pages: 239

ISBN-13: 3319030353

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Recent achievements in hardware and software developments have enabled the introduction of a revolutionary technology: in-memory data management. This technology supports the flexible and extremely fast analysis of massive amounts of data, such as diagnoses, therapies, and human genome data. This book shares the latest research results of applying in-memory data management to personalized medicine, changing it from computational possibility to clinical reality. The authors provide details on innovative approaches to enabling the processing, combination, and analysis of relevant data in real-time. The book bridges the gap between medical experts, such as physicians, clinicians, and biological researchers, and technology experts, such as software developers, database specialists, and statisticians. Topics covered in this book include - amongst others - modeling of genome data processing and analysis pipelines, high-throughput data processing, exchange of sensitive data and protection of intellectual property. Beyond that, it shares insights on research prototypes for the analysis of patient cohorts, topology analysis of biological pathways, and combined search in structured and unstructured medical data, and outlines completely new processes that have now become possible due to interactive data analyses.

High Performance Computing
High Performance Computing

Author: Ponnuswamy Sadayappan

Publisher:

Published: 2020

Total Pages: 0

ISBN-13: 9788303050748

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This book constitutes the refereed proceedings of the 35th International Conference on High Performance Computing, ISC High Performance 2020, held in Frankfurt/Main, Germany, in June 2020.* The 27 revised full papers presented were carefully reviewed and selected from 87 submissions. The papers cover a broad range of topics such as architectures, networks & infrastructure; artificial intelligence and machine learning; data, storage & visualization; emerging technologies; HPC algorithms; HPC applications; performance modeling & measurement; programming models & systems software. *The conference was held virtually due to the COVID-19 pandemic. Chapters "Scalable Hierarchical Aggregation and Reduction Protocol (SHARP) Streaming-Aggregation Hardware Design and Evaluation", "Solving Acoustic Boundary Integral Equations Using High Performance Tile Low-Rank LU Factorization", "Scaling Genomics Data Processing with Memory-Driven Computing to Accelerate Computational Biology", "Footprint-Aware Power Capping for Hybrid Memory Based Systems", and "Pattern-Aware Staging for Hybrid Memory Systems" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

A Course in In-Memory Data Management
A Course in In-Memory Data Management

Author: Hasso Plattner

Publisher: Springer

Published: 2014-05-28

Total Pages: 315

ISBN-13: 3642552706

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Recent achievements in hardware and software development, such as multi-core CPUs and DRAM capacities of multiple terabytes per server, enabled the introduction of a revolutionary technology: in-memory data management. This technology supports the flexible and extremely fast analysis of massive amounts of enterprise data. Professor Hasso Plattner and his research group at the Hasso Plattner Institute in Potsdam, Germany, have been investigating and teaching the corresponding concepts and their adoption in the software industry for years. This book is based on an online course that was first launched in autumn 2012 with more than 13,000 enrolled students and marked the successful starting point of the openHPI e-learning platform. The course is mainly designed for students of computer science, software engineering, and IT related subjects, but addresses business experts, software developers, technology experts, and IT analysts alike. Plattner and his group focus on exploring the inner mechanics of a column-oriented dictionary-encoded in-memory database. Covered topics include - amongst others - physical data storage and access, basic database operators, compression mechanisms, and parallel join algorithms. Beyond that, implications for future enterprise applications and their development are discussed. Step by step, readers will understand the radical differences and advantages of the new technology over traditional row-oriented, disk-based databases. In this completely revised 2nd edition, we incorporate the feedback of thousands of course participants on openHPI and take into account latest advancements in hard- and software. Improved figures, explanations, and examples further ease the understanding of the concepts presented. We introduce advanced data management techniques such as transparent aggregate caches and provide new showcases that demonstrate the potential of in-memory databases for two diverse industries: retail and life sciences.

Next-Generation Sequencing Data Analysis
Next-Generation Sequencing Data Analysis

Author: Xinkun Wang

Publisher: CRC Press

Published: 2016-04-06

Total Pages: 252

ISBN-13: 1482217899

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A Practical Guide to the Highly Dynamic Area of Massively Parallel SequencingThe development of genome and transcriptome sequencing technologies has led to a paradigm shift in life science research and disease diagnosis and prevention. Scientists are now able to see how human diseases and phenotypic changes are connected to DNA mutation, polymorphi

High Performance Computing
High Performance Computing

Author: Julian M. Kunkel

Publisher: Springer

Published: 2016-06-14

Total Pages: 506

ISBN-13: 331941321X

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This book constitutes the refereed proceedings of the 31st International Conference, ISC High Performance 2016 [formerly known as the International Supercomputing Conference] held in Frankfurt, Germany, in June 2016. The 25 revised full papers presented in this book were carefully reviewed and selected from 60 submissions. The papers cover the following topics: Autotuning and Thread Mapping; Data Locality and Decomposition; Scalable Applications; Machine Learning; Datacenters andCloud; Communication Runtime; Intel Xeon Phi; Manycore Architectures; Extreme-scale Computations; and Resilience.

Contemporary High Performance Computing
Contemporary High Performance Computing

Author: Jeffrey S. Vetter

Publisher: CRC Press

Published: 2017-11-23

Total Pages: 730

ISBN-13: 1466568356

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Contemporary High Performance Computing: From Petascale toward Exascale focuses on the ecosystems surrounding the world’s leading centers for high performance computing (HPC). It covers many of the important factors involved in each ecosystem: computer architectures, software, applications, facilities, and sponsors. The first part of the book examines significant trends in HPC systems, including computer architectures, applications, performance, and software. It discusses the growth from terascale to petascale computing and the influence of the TOP500 and Green500 lists. The second part of the book provides a comprehensive overview of 18 HPC ecosystems from around the world. Each chapter in this section describes programmatic motivation for HPC and their important applications; a flagship HPC system overview covering computer architecture, system software, programming systems, storage, visualization, and analytics support; and an overview of their data center/facility. The last part of the book addresses the role of clouds and grids in HPC, including chapters on the Magellan, FutureGrid, and LLGrid projects. With contributions from top researchers directly involved in designing, deploying, and using these supercomputing systems, this book captures a global picture of the state of the art in HPC.

EHealth - For Continuity of Care
EHealth - For Continuity of Care

Author: C. Lovis

Publisher: IOS Press

Published: 2014-09-30

Total Pages: 1328

ISBN-13: 1614994323

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Information technology and the information sciences have been part of our lives for some time now. They have revolutionized the healthcare system, changing the whole health landscape, as well as health culture. New devices, sources of data and roles for all those involved in healthcare are being developed as a result. This book presents the proceedings of the 25th European Medical Informatics Conference, held in Istanbul, Turkey in August/September 2014. The conference aims to present the most recent developments in biomedical informatics. The book is divided into 15 sections, which include: decision support systems and clinical practice guidelines; improved healthcare through informatics; data analysis; mobile health; technology and system evaluation; and text mining. The final two sections present posters from the conference. The book will be of interest to all those in the healthcare sector, researchers and practitioners alike, who develop, evaluate or work with information technology.

Cloud Computing
Cloud Computing

Author: Nick Antonopoulos

Publisher: Springer

Published: 2017-06-02

Total Pages: 418

ISBN-13: 3319546457

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This practically-focused reference presents a comprehensive overview of the state of the art in Cloud Computing, and examines the potential for future Cloud and Cloud-related technologies to address specific industrial and research challenges. This new edition explores both established and emergent principles, techniques, protocols and algorithms involved with the design, development, and management of Cloud-based systems. The text reviews a range of applications and methods for linking Clouds, undertaking data management and scientific data analysis, and addressing requirements both of data analysis and of management of large scale and complex systems. This new edition also extends into the emergent next generation of mobile telecommunications, relating network function virtualization and mobile edge Cloud Computing, as supports Smart Grids and Smart Cities. As with the first edition, emphasis is placed on the four quality-of-service cornerstones of efficiency, scalability, robustness, and security.

Encyclopedia of Bioinformatics and Computational Biology
Encyclopedia of Bioinformatics and Computational Biology

Author:

Publisher: Elsevier

Published: 2018-08-21

Total Pages: 3421

ISBN-13: 0128114320

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Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Transactions on Large-Scale Data- and Knowledge-Centered Systems XLVI
Transactions on Large-Scale Data- and Knowledge-Centered Systems XLVI

Author: Abdelkader Hameurlain

Publisher: Springer Nature

Published: 2020-11-20

Total Pages: 197

ISBN-13: 3662623862

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The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing (e.g., computing resources, services, metadata, data sources) across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. This, the 46th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains six fully revised selected regular papers. Topics covered include an elastic framework for genomic data management, medical data cloud federations, temporal pattern mining, scalable schema discovery, load shedding, and selectivity estimation using linked Bayesian networks.