Hemoperfusion, Plasmaperfusion And Other Clinical Uses Of General, Biospecific, Immuno And Leucocyte Adsorbents
Hemoperfusion, Plasmaperfusion And Other Clinical Uses Of General, Biospecific, Immuno And Leucocyte Adsorbents

Author: Thomas Ming Swi Chang

Publisher: World Scientific

Published: 2017-02-17

Total Pages: 1015

ISBN-13: 9814749095

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Written by 30 worldwide leading scientists, experts and medical doctors, this comprehensive book provides a broad, multi-disciplinary overview on hemoperfusion. The research of the subject was started by TMS Chang — the pioneer and inventor of microcapsules who is well known as the 'the Father of Microcapsules.' The book presents the numerous recent developments in this field. A series of tailor-made, toxin removing and cell separating adsorbents or microcapsules with unique properties have been designed, prepared and produced for use in the treatment of diseases such as autoimmune disease, drug over-dose, acute inflammation, etc., in which ordinary medical treatments shows little or no efficacy. Various modalities of hemoperfusion treatments and results are described to provide readers with up-to-date information on the highly interdisciplinary field of hemoperfusion.

ABO-incompatible Kidney Transplantation
ABO-incompatible Kidney Transplantation

Author: Kōta Takahashi

Publisher:

Published: 2001

Total Pages: 180

ISBN-13:

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ABO incompatible kidney transplantation is indicated for patients for whom no ABO-identical or minor mismatch donor is available. Since the author and his colleagues performed the first ABO-incompatible kidney transplantation in Japan in 1989, 400 such transplantations have been performed in 41 hospitals in Japan and this practice has contributed to a number of new developments. One is a clearer and more suitable model for conceptualising the mechanism of humoral immune response which enables identification of antigens and antibodies and a therapeutic strategy against rejection. The rejection mechanisms are discussed not only from the perspective of immunology but also viewed from different angles, including anatomy, microscopic and macroscopic pathology, molecular biology and haematology. Immunosuppressive therapy is discussed, divided in four categories: extracorporeal immunomodulation with removal of humoral antibodies; drug therapy to suppress cellular immunity; splenectomy; and anticoagulation therapy. Surgical procedures for kidney transplantation and splenectomy are treated, including discussion of the best timing for the latter. The book gives an overview of the current status with statistics and results of questionnaires and ends with discussions of 17 case histories.

Alphaherpesviruses
Alphaherpesviruses

Author: Sandra Knowles Weller

Publisher: Caister Academic Press Limited

Published: 2011

Total Pages: 0

ISBN-13: 9781904455769

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Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

Body Fluid Management
Body Fluid Management

Author: F.E. Agro

Publisher: Springer Science & Business Media

Published: 2012-08-21

Total Pages: 271

ISBN-13: 8847026601

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The administration of intravenous fluids is one of the most common and important therapeutic practices in the treatment of surgical, medical and critically ill patients. The international literature accordingly contains a vast number of works on fluid management, yet there is still confusion as to the best options in the various situations encountered in clinical practice. The purpose of this volume is to help the decision-making process by comparing different solution properties describing their indications, mechanisms of action and side-effects according to physiologic body water distribution, electrolytic and acid-base balance, and to clarify which products available on the market represent the best choice in different circumstances. The book opens by discussing in detail the concepts central to a sound understanding of abnormalities in fluid and electrolyte homeostasis and the effect of intravenous fluid administration. In the second part of the monograph, these concepts are used to explain the advantages and disadvantages of solutions available on the market in different clinical settings. Body Fluid Management: From Physiology to Therapy will serve as an invaluable decision-making guide, including for those who are not experts in the subject.

The Chromosomal Proteins
The Chromosomal Proteins

Author: E Johns

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 262

ISBN-13: 0323158749

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The HMG Chromosomal Proteins focuses on various research on HMG proteins, particularly their association with active genes. Composed of literature of authors that are divided into 10 chapters, the book starts with the discussions on the history and problems in the study of chromosomal proteins. The text proceeds with the discussions on the occurrence of HMG proteins in eukaryotes; tissue specificity of HMG proteins; and species specificity and evolution of HMG proteins. The book presents techniques that are used to analyze HMG proteins and provides information on the primary structures of different proteins, such as HMG 14 and HMG 17, and the methods for cleaving these proteins. The processes involved in isolating proteins and postsynthetic modifications of their structures are noted, clarified with the study done on the HMG proteins of rainbow trout. The text ends with discussions on the association of HMG proteins with chromatin and nucleosomes and a tabulation of accumulated data. This selection is valuable for readers interested in studying HMG proteins.