Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Author: Richard K. Burt

Publisher: CRC Press

Published: 2021-11-17

Total Pages: 687

ISBN-13: 1351364766

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This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Stem Cell Therapy for Autoimmune Disease
Stem Cell Therapy for Autoimmune Disease

Author: Richard K. Burt

Publisher: CRC Press

Published: 2019-11-11

Total Pages: 512

ISBN-13: 1000716856

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Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Stem Cell Transplantation for Autoimmune Diseases and Inflammation
Stem Cell Transplantation for Autoimmune Diseases and Inflammation

Author: Phuc Van Pham

Publisher: Springer

Published: 2019-08-13

Total Pages: 163

ISBN-13: 3030234215

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This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.

Manual of Hematopoietic Cell Transplantation and Cellular Therapies - E-Book
Manual of Hematopoietic Cell Transplantation and Cellular Therapies - E-Book

Author: Qaiser Bashir

Publisher: Elsevier Health Sciences

Published: 2022-12-23

Total Pages: 608

ISBN-13: 0323798349

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Led by authors from MD Anderson’s Stem Cell Transplantation and Cellular Therapy Department, the world’s largest and highly respected program at the forefront of rapidly advancing treatments in the field, Manual of Hematopoietic Cell Transplantation and Cellular Therapies is a comprehensive, focused reference covering the latest clinical developments and applications of stem cell transplant and cellular therapies for hematologic malignancies and solid tumors. This cutting-edge title, with a majority contribution from the MD Anderson Cancer Center and leading faculty from other academic institutions, covers breakthrough cell-based therapies for various diseases including lymphoma, multiple myeloma, leukemia, and select solid tumor and autoimmune diseases. This unique, definitive resource is essential for hematologists, fellows in hematology and immunotherapy, mid-level providers, pharmacists, and oncologists who refer patients for cell-based therapies. Addresses hematologic conditions including leukemia, lymphoma, and myeloma. Offers guidance on hematopoietic cell transplantation for solid tumors. Covers basic science principles, clinical aspects, pharmacology, radiation therapy, and disease-specific guidelines, including prevention and management of complications. Discusses key topics such as hematopoietic cell collection, bone marrow harvesting, umbilical cord blood transplantation, CAR T-cell therapy, and patient/donor selection and preparation of HCT. Features extensive summary boxes, bulleted content, and algorithms throughout for quick and easy reference. Offers team-based, clinically-focused coverage from world-renowned leaders in the field.

The EBMT Handbook
The EBMT Handbook

Author: Nicolaus Kröger

Publisher:

Published: 2020-10-08

Total Pages: 688

ISBN-13: 9781013273674

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This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Non-Myeloablative Allogeneic Transplantation
Non-Myeloablative Allogeneic Transplantation

Author: Asad Bashey

Publisher: Springer Science & Business Media

Published: 2002-02-28

Total Pages: 240

ISBN-13: 9780792376460

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Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Everyday Miracles
Everyday Miracles

Author: Dr. Richard Burt

Publisher: Simon and Schuster

Published: 2023-01-10

Total Pages: 129

ISBN-13: 1637631251

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A life-changing treatment is conquering auto-immune disorders—why doesn’t anyone know about it? Thirty-five years ago, Dr. Richard Burt began a journey to treat chronic autoimmune diseases as they’d never been treated before. Using a treatment originally developed for leukemia but modified to be more gentle—a one-time combination of immune targeting drugs followed by a transplant of the patient’s blood stem cells—he has documented the successful and often dramatic reversal of multiple sclerosis, systemic sclerosis (scleroderma), chronic inflammatory demyelinating polyradiculoneuropathy (CIPD), neuromyelitis optica, and Crohn’s disease. After decades of study and randomized trials, his approach, which has been duplicated in other parts of the world, is finally being recognized as an effective means of reversing these “incurable” diseases. Some of his patients have been symptom-free for more than twenty years, and in this book Dr. Burt tells their stories alongside his own journey of developing and refining the treatment, known as hematopoietic stem cell transplant (HSCT) for autoimmune disorders. “These patients are the heroes,” Dr. Burt has said. “Their bodies and spirits faced unrelenting disease, and yet they fight valiantly against the suffering and obstacles.” What is HSCT? How does it work? What are the risks? Why aren’t more doctors talking about it? And why is it still out of reach for so many patients who could benefit from it? Dr. Burt answers these questions and many more. Written for the layperson, Everyday Miracles grants patients with autoimmune diseases and the people who love them insights into the revolutionary approach that could convert their life sentence into a one-time reversible illness.

The European Blood and Marrow Transplantation Textbook for Nurses
The European Blood and Marrow Transplantation Textbook for Nurses

Author: Michelle Kenyon

Publisher: Springer

Published: 2018-03-14

Total Pages: 318

ISBN-13: 3319500260

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This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Immune Profile after Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: Where Do We Stand?
Immune Profile after Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: Where Do We Stand?

Author: Kelen Cristina Ribeiro Malmegrim

Publisher: Frontiers Media SA

Published: 2020-02-12

Total Pages: 135

ISBN-13: 2889634728

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Autologous hematopoietic stem cell transplantation (AHSCT) was proposed 20 years ago as an alternative therapeutic approach for patients with severe and refractory autoimmune diseases. Since then, this innovative therapy has been successfully used to treat several autoimmune diseases, such as neurological disorders (Multiple Sclerosis), connective tissue diseases (Systemic Sclerosis and Systemic Lupus Erythematous), gastrointestinal inflammatory diseases (Crohn’s Disease) and others (Juvenile Arthritis, Type 1 Diabetes, Vasculitis). Experience in phase I-II and III clinical trials over the years has led to increased safety and efficacy of this procedure. Recent studies have demonstrated superior therapeutic efficacy of AHSCT versus conventional therapies, showing that transplantation can induce long-term disease remission in the absence of any further immunosuppressive treatment. Immune monitoring studies have showed that AHSCT is able to reduce the inflammatory milieu, to reset the immune balance and to promote the generation of a new auto-tolerant immune repertoire. However, some patients fail to remain in remission, and disease is re-activated after some time post-transplantation. This scenario indicates that further immunological interventions may be still required to improve AHSCT efficacy. Clear understanding of the operating immune mechanisms that contribute to specific clinical outcomes is vital to enable improvement of AHSCT protocols for autoimmune diseases.

Advances in Allogeneic Hematopoietic Stem Cell Transplantation
Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Author: Richard K. Burt

Publisher: Springer

Published: 2012-11-28

Total Pages: 419

ISBN-13: 1461549876

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The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).