Hargobind Khorana
Author: Nandini
Publisher: Prabhat Prakashan
Published: 2021-01-01
Total Pages: 13
ISBN-13: 9351861554
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Chemical Biology, Selected Papers Of H G Khorana (With Introductions)
Author: H Gobind Khorana
Publisher: World Scientific
Published: 2000-05-24
Total Pages: 633
ISBN-13: 9814496650
DOWNLOAD EBOOKThe first two chapters of this invaluable book trace the developments of the chemistry and macromolecular structures, respectively, of proteins and nuclei acids. Similarly, the introductions to the succeeding chapters review, step by step, the historical landmarks in the topics covered. These include discoveries of biological phosphate esters, nucleotides and nucleotide coenzymes (important in intermediary metabolism), the nature of the genetic material and biological synthesis of proteins, formulation of the problem of the genetic code, and perspectives on bioenergetics.The selected papers illustrate the developments of the chemical synthesis of nucleotides and nucleotide coenzymes of ribo- and deoxy-ribo-polynucleotides (RNA, DNA), of the total synthesis of genes in the laboratory, and principles for gene amplification (PCR). Another major section covers studies of enzymes that degrade nucleic acids, the structure of transfer RNA and its role in protein synthesis, and the author's work on the elucidation of the genetic code. Finally, there are descriptions of the studies on biological membranes and the membrane protein bacteriorhodopsin, a biological proton pump. These studies elucidated the mechanism of proton translocation, which is central to bioenergetics.
Landmark Experiments in Molecular Biology
Author: Michael Fry
Publisher: Academic Press
Published: 2016-06-10
Total Pages: 572
ISBN-13: 012802108X
DOWNLOAD EBOOKLandmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. - Includes detailed analysis of classically designed and executed experiments - Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries - Provides critical analysis of the history of molecular biology to inform the future of scientific discovery - Examines the machinery of inheritance and biological information handling
The Least Likely Man
Author: Franklin H. Portugal
Publisher: MIT Press
Published: 2015-02-06
Total Pages: 198
ISBN-13: 0262028476
DOWNLOAD EBOOKHow unassuming government researcher Marshall Nirenberg beat James Watson, Francis Crick, and other world-famous scientists in the race to discover the genetic code. The genetic code is the Rosetta Stone by which we interpret the 3.3 billion letters of human DNA, the alphabet of life, and the discovery of the code has had an immeasurable impact on science and society. In 1968, Marshall Nirenberg, an unassuming government scientist working at the National Institutes of Health, shared the Nobel Prize for cracking the genetic code. He was the least likely man to make such an earth-shaking discovery, and yet he had gotten there before such members of the scientific elite as James Watson and Francis Crick. How did Nirenberg do it, and why is he so little known? In The Least Likely Man, Franklin Portugal tells the fascinating life story of a famous scientist that most of us have never heard of. Nirenberg did not have a particularly brilliant undergraduate or graduate career. After being hired as a researcher at the NIH, he quietly explored how cells make proteins. Meanwhile, Watson, Crick, and eighteen other leading scientists had formed the “RNA Tie Club” (named after the distinctive ties they wore, each decorated with one of twenty amino acid designs), intending to claim credit for the discovery of the genetic code before they had even worked out the details. They were surprised, and displeased, when Nirenberg announced his preliminary findings of a genetic code at an international meeting in Moscow in 1961. Drawing on Nirenberg's “lab diaries,” Portugal offers an engaging and accessible account of Nirenberg's experimental approach, describes counterclaims by Crick, Watson, and Sidney Brenner, and traces Nirenberg's later switch to an entirely new, even more challenging field. Having won the Nobel for his work on the genetic code, Nirenberg moved on to the next frontier of biological research: how the brain works.
Life's Greatest Secret
Author: Matthew Cobb
Publisher: Hachette UK
Published: 2015-07-07
Total Pages: 464
ISBN-13: 0465062660
DOWNLOAD EBOOKEveryone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life's) future. Life's Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters -- mathematicians, physicists, information theorists, and biologists -- who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or "junk DNA" was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb's telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who'd like to explore those questions for themselves.
Sources of Medical Technology
Author: Committee on Technological Innovation in Medicine
Publisher: National Academies Press
Published: 1995-01-15
Total Pages: 255
ISBN-13: 0309587611
DOWNLOAD EBOOKEvidence suggests that medical innovation is becoming increasingly dependent on interdisciplinary research and on the crossing of institutional boundaries. This volume focuses on the conditions governing the supply of new medical technologies and suggest that the boundaries between disciplines, institutions, and the private and public sectors have been redrawn and reshaped. Individual essays explore the nature, organization, and management of interdisciplinary R&D in medicine; the introduction into clinical practice of the laser, endoscopic innovations, cochlear implantation, cardiovascular imaging technologies, and synthetic insulin; the division of innovating labor in biotechnology; the government- industry-university interface; perspectives on industrial R&D management; and the growing intertwining of the public and proprietary in medical technology.
Comprehensive Biochemistry for Dentistry
Author: Anil Gupta
Publisher: Springer
Published: 2018-12-30
Total Pages: 617
ISBN-13: 9811310351
DOWNLOAD EBOOKThis book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitamins and hormones, enriched with flow charts and diagrams for easy understanding and quick reference. It includes chapters on nucleic acids, nutrition and serum enzymes and organ function tests, and offers an innovative approach to familiarize dental students with the biochemical composition of enamel, dentine, cementum and saliva, explaining the biochemical basis of dental caries, periodontal diseases, role of fluorides in caries prophylaxis, fluoride toxicity, and the role of amino acids as anti-hypersensitive agents.
20 Indians Who Changed the World
Author: Shruthi Rao
Publisher:
Published: 2019-05-10
Total Pages: 242
ISBN-13: 9789388874724
DOWNLOAD EBOOKA brilliant collection of profiles of 20 trailblazing Indians who changed the world with their ideas, innovation and discoveries. For over 3000 years, the Indian subcontinent has contributed to fields as diverse as mathematics and science, spirituality and philosophy, as well as music and literature. In this absorbing book, Shruthi Rao profiles 20 legendary Indians who dared to think differently and changed the world--from starting a new religion based on the principles of compassion and peace; to creating the first set of rules for grammar; to discovering the existence of black holes, and so much more. 20 Indians Who Changed the World is as informative and well-researched as it is inspiring, a book every Indian can read with pride. Amartya Sen Ashoka Bhaskara II (Bhaskaracharya) Buddha C.V. Raman Faqir Chand Kohli Har Gobind Khorana Indra K. Nooyi Jawaharlal Nehru Kalpana Chawla Mohandas Karamchand Gandhi Mother Teresa Narinder Singh Kapany Pandit Ravi Shankar Panini Rabindranath Tagore Subrahmanyan Chandrasekhar Swami Vivekananda Tipu Sultan Venkatraman Ramakrishnan
Primates
Author: Jim Ottaviani
Publisher: Macmillan
Published: 2013-06-11
Total Pages: 146
ISBN-13: 1596438657
DOWNLOAD EBOOKA fun and immersive look into the lives of the three greatest primatologists of the twentieth century: Biruté Galdikas, Dian Fossey, and Jane Goodall, from the #1 New York Times bestselling author of Feynman.
Fred Sanger - Double Nobel Laureate
Author: George G. Brownlee
Publisher: Cambridge University Press
Published: 2020-04-02
Total Pages: 315
ISBN-13: 1316124053
DOWNLOAD EBOOKConsidered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.
