The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives
Molecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundamental knowledge about key challenges of these carriers down to the molecular level. The book satisfies the need of availability of literature at single platform with the detailed knowledge to understand crucial aspects, such as regulatory, clinical, toxicological and the formulation requirements of these carriers. This is a valuable resource for graduates, pharmaceutical researchers and anyone working on aspects of pharmaceutics, molecular pharmaceutics and nano-drug/gene delivery. So called 'novel drug delivery systems' are numerous, with each having different approaches to their production, characterization and evaluation. The proper understanding of these dosage forms, as well as their critical attributes such as toxicity and regulatory requirements are aspects which researchers should know before they begin working on these carriers. This book provides this critical information. - Provides a conceptual understanding of Molecular Pharmaceutics and drug/gene delivery systems of biological origin - Presents a detailed description and discussion on nanotechnological carriers, from basics to advances, including gene delivery and protein-oriented delivery - Includes regulatory and toxicological requirements for novel drug delivery systems
As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered. KEY FEATURES • Discusses source of the drug or chemical, pharmacological and toxicological mechanisms of action, detection, identification, and treatment • Examines the complex interactions associated with clinical toxicological events • Emphasizes the signs and symptoms of diseases and pathology caused by toxins and clinical drugs • Covers effect of toxins on body systems and drug-induced adverse reactions • Offers a unique perspective for toxicology, pharmacology, pharmacy and health professions students The target audience for this book is undergraduate and graduate toxicology students, clinical pharmacy (Pharm.D.) students, emergency medical personnel, regulatory agencies, and other related health science professionals. It satisfies an essential need for a concise yet detailed authoritative, fundamental text addressing the current principles of clinical toxicology.
Computational Biology for Stem Cell Research is an invaluable guide for researchers as they explore HSCs and MSCs in computational biology. With the growing advancement of technology in the field of biomedical sciences, computational approaches have reduced the financial and experimental burden of the experimental process. In the shortest span, it has established itself as an integral component of any biological research activity. HSC informatics (in silico) techniques such as machine learning, genome network analysis, data mining, complex genome structures, docking, system biology, mathematical modeling, programming (R, Python, Perl, etc.) help to analyze, visualize, network constructions, and protein-ligand or protein-protein interactions. This book is aimed at beginners with an exact correlation between the biomedical sciences and in silico computational methods for HSCs transplantation and translational research and provides insights into methods targeting HSCs properties like proliferation, self-renewal, differentiation, and apoptosis. - Modeling Stem Cell Behavior: Explore stem cell behavior through animal models, bridging laboratory studies to real-world clinical allogeneic HSC transplantation (HSCT) scenarios. - Bioinformatics-Driven Translational Research: Navigate a path from bench to bedside with cutting-edge bioinformatics approaches, translating computational insights into tangible advancements in stem cell research and medical applications. - Interdisciplinary Resource: Discover a single comprehensive resource catering to biomedical sciences, life sciences, and chemistry fields, offering essential insights into computational tools vital for modern research.
Advances in Bionanocomposites: Materials, Applications, and Life Cycle brings together the latest research in bio-based nanocomposites, with a strong emphasis on improved sustainability in terms of preparation, lifecycle and end applications. The book begins by introducing biopolymers, bionanocomposites and the latest methods for their synthesis, processing and characterization. Other sections focus on specific bio-based materials, including bionanocomposites based on polylactic acid, poly(vinyl alcohol), chitosan, starch, cellulose, and protein. A range of advanced applications are then introduced across 3D printing, high entropy alloys, wastewater remediation, agriculture, biomedicine, solar cells, electrochemical sensors, and packaging. Throughout the book, opportunities for improved sustainability are analyzed and highlighted. The final section brings this together with in-depth coverage of biodegradation, lifecycle, environmental impact, circular economy, economic considerations and future opportunities in bionanocomposites. This is a valuable resource for researchers, advanced students, R&D professionals, and industrial scientists from a range of disciplines. - Provides the latest cutting-edge techniques for the synthesis, processing and characterization of biopolymer-based materials - Includes an approach to bionanocomposites from the perspective of environmental impact, lifecycle and sustainability - Opens the door to novel applications in areas such as 3D printing, wastewater remediation, agriculture and solar cells
Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions. Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful. - Includes smart sensing materials such as smart electro-active nanomaterials, sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical system, and device integration and interfacing for point-of-care applications - Describes each component involved in the development of an efficient cancer diagnostics system - Focuses on fundamental and applied concepts of the technologies, along with the related mechanisms proposed for diagnostics of cancer - Enhances fundamental understandings of the concepts and development of nanotechnology based analytical tools and novel techniques for early stage cancer diagnostics and management
This third volume on environmental nanotechnology includes chapters dealing with topics such nanoremediation, waste water purification, nanosensors, nanomedicine, and nanofiltration. It also highlights the safety aspects and risk assessment and management related to several toxins, as well as nanotechnology related solutions for these challenges. The book also discusses new nanomaterials from the nexus of environment, water, remediation and total environment.
Provides detailed information about the use of nanotechnology in remediating waste and pollution in agriculture Nano-Technological Intervention in Agricultural Productivity explores sustainable, eco-friendly technologies for remediating wastes and contaminated areas in both water and land ecosystems. Focusing on nano-technological innovations that use microbes and microbial agents to improve the quality and pollutant discharge of contaminated sites, this comprehensive volume also discusses molecular approaches for the characterization of nanoparticles, the biosynthetic pathways of microbes, gene and protein expression studies for bio-deterioration techniques, and more. Organized into nine chapters, the book opens with a thorough overview of the functions, classification, properties, synthesis, and applications of nanoparticles. Following a discussion of the environmental and agricultural implications of nanotechnology, the authors examine the current role and future prospects of nanotechnology in managing plant diseases, improving agri-food production, and increasing agricultural productivity. Subsequent chapters cover lignin nanoparticles, various applications of nanotechnology in agriculture, and nano-based advances in plant and microbial science. Offering an up-to-date account of the role of nanotechnologies in agricultural bioremediation, this book: Explores biotechnological advances in the development of sophisticated green technologies for waste minimization and waste control Emphasizes the use of microbes for degradation and removal of various xenobiotic substances Discusses bioremediation approaches in relation to the impact of increased urbanization and industrialization on the environment Covers a variety of applications of nanotechnology in agriculture, including nano-fertilizers, nano-biosensors, nano-pesticides, and nanoparticle protection in plants Nano-Technological Intervention in Agricultural Productivity is a valuable resource for students in plant biotechnology and agricultural science and engineering, as well as an important reference for researchers in plant biotechnology and agricultural sciences, particularly those with interest in the use of nanomaterials for pollution remediation and sustainable development.
Emerging Contaminants: Sustainable Agriculture and the Environment provides a thorough, comprehensive, and interdisciplinary overview of the many categories of emerging pollutants, including pharmaceuticals, insecticides, personal care items, and industrial chemicals that are currently impacting the environment. With insights into the exposure associated consequences on crops and edible plants, the book is designed to enable foundational understanding as the basis for future research, as well as practical application in current environments. Following an introduction to environmental contaminants, the book goes on to discuss their fate in soils, the most up-to-date analytical methods for detecting them in different environmental matrices, and current regulatory restrictions. Finally, the book comes to a close with the last chapter dedicated to conclusions and future perspectives. Emerging Contaminants is an ideal resource for researchers and professionals from a variety of sciences. - Focuses on the extensive emission of ECs raising concerns of toxicity in crop plants, in the environment, and also to human beings via the food chain - Includes examples and real-world insights - Highlights interaction of different categories of ECs with crop plants their toxicity and fate in the environment
