Handbook of Chemical Glycosylation
Handbook of Chemical Glycosylation

Author: Alexei V. Demchenko

Publisher: John Wiley & Sons

Published: 2008-04-09

Total Pages: 524

ISBN-13: 3527621652

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Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.

Handbook of Glycomics
Handbook of Glycomics

Author: Richard D. Cummings

Publisher: Academic Press

Published: 2009-10-19

Total Pages: 507

ISBN-13: 0080920055

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The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans. - Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine - Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics - Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

Selective Glycosylations
Selective Glycosylations

Author: Clay S. Bennett

Publisher: John Wiley & Sons

Published: 2017-01-19

Total Pages: 500

ISBN-13: 3527696245

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A comprehensive summary of novel approaches to the stereoselective construction of glycosidic linkages, covering modern glycosylation methods and their use and application in natural product synthesis and drug discovery. Clearly divided into five sections, the first describes recent advances in classical methodologies in carbohydrate chemistry, while the second goes on to deal with newer chemistries developed to control selectivity in glycosylation reactions. Section three is devoted to selective glycosylation reactions that rely on the use of catalytic promoters. Section four describes modern approaches for controlling regioselectivity in carbohydrate synthesis. The final section focuses on new developments in the construction of "unusual" sugars and is rounded off by a presentation of modern procedures for the construction of glycosylated natural products. By providing the latest advances in glycosylation as well as information on mechanistic aspects of the reaction, this is an invaluable reference for both specialists and beginners in this booming interdisciplinary field that includes carbohydrate chemistry, organic synthesis, catalysis, and biochemistry.

Handbook Oligosaccharides Trisaccharides
Handbook Oligosaccharides Trisaccharides

Author: Andras Liptak

Publisher: CRC-Press

Published: 1990-10-24

Total Pages: 280

ISBN-13: 9780849329029

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Chemical synthesis of oligosaccharides is important to organic chemistry because of the critical biological functions of carbohydrates. Unfortunately, no handbook has been published on the subject...until now. Volume 1: Disaccharides presents synthetic carbohydrate chemistry, lists the syntheses, and shows the route of each synthesis. Volume 2: Trisaccharides presents schematic figures and references. This series includes all oligosaccharides synthesized between 1960 and 1986. This allows oligosaccharides prepared in their free form to be presented, as well as those produced in protected form. The series contains data regarding glycosylation reaction, namely reaction conditions (solvent, promoter, temperature), the aglycon and the glycosyl donor used, and the structure and physical data of the isolated product. For disaccharides, the names of the reactants and the products are revealed, while with trisaccharides and higher oligomers, schematic figures provide a quick and easy way to access information concerning the entire process. These volumes will provide an important reference source for biochemists, biologists, and organic chemists.

Glycoscience
Glycoscience

Author: Bertram O. Fraser-Reid

Publisher: Springer Science & Business Media

Published: 2008-04-14

Total Pages: 2847

ISBN-13: 3540361545

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As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.

Handbook of Carbohydrate Engineering
Handbook of Carbohydrate Engineering

Author: Kevin J. Yarema

Publisher: CRC Press

Published: 2005-05-27

Total Pages: 944

ISBN-13: 1420027638

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The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field. The text provides background information along with practical knowledge for current and future research methodologies used in the characterization and synthesis of various carbohydrates. This

Essentials of Glycobiology
Essentials of Glycobiology

Author: Ajit Varki

Publisher: CSHL Press

Published: 1999

Total Pages: 694

ISBN-13: 9780879696818

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Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Handbook of Oligosaccharides Disaccharides
Handbook of Oligosaccharides Disaccharides

Author: Andras Liptak

Publisher: CRC-Press

Published: 1990-06-22

Total Pages: 0

ISBN-13: 9780849329012

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Chemical synthesis of oligosaccharides is important to organic chemistry because of the critical biological functions of carbohydrates. Unfortunately, no handbook has been published on the subject...until now. Volume 1: Disaccharides presents synthetic carbohydrate chemistry, lists the syntheses, and shows the route of each synthesis. Volume 2: Trisaccharides presents schematic figures and references. This series includes all oligosaccharides synthesized between 1960 and 1986. This allows oligosaccharides prepared in their free form to be presented, as well as those produced in protected form. The series contains data regarding glycosylation reaction, namely reaction conditions (solvent, promoter, temperature), the aglycon and the glycosyl donor used, and the structure and physical data of the isolated product. For disaccharides, the names of the reactants and the products are revealed, while with trisaccharides and higher oligomers, schematic figures provide a quick and easy way to access information concerning the entire process. These volumes will provide an important reference source for biochemists, biologists, and organic chemists.

Development of the Regenerative Glycosylation Approach for Manual and Automated Oligosaccharide Synthesis
Development of the Regenerative Glycosylation Approach for Manual and Automated Oligosaccharide Synthesis

Author: Swati Sudhir Nigudkar

Publisher:

Published: 2014

Total Pages: 251

ISBN-13:

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It has been recognized that carbohydrates are involved in all phases of life beginning with the embryonic development and cell growth. However, it is the involvement of carbohydrates in the progression of various deadly diseases that gave these natural compounds significant roles in diagnostics and as pharmaceuticals. Although carbohydrates are highly desirable to the biological and medical communities, these molecules are still very challenging targets for chemists. Functionalization, derivatization, controlling anomeric stereoselectivity, purification, and characterization are all existing experimental hurdles towards producing synthetic carbohydrates in large quantities and high purity. Advances in chemistry and biochemistry have certainly facilitated the synthesis and purification of carbohydrates. However, the development of practical and general methods for chemical glycosylation and expeditious oligosaccharide synthesis remain an important and challenging area of research. This topic has also become the basis for this doctoral dissertation wherein the focus was primarily placed on the development of new leaving groups for chemical glycosylation and designing novel methods and technologies for efficient oligosaccharide synthesis. One outcome of this study is the development of two new classes of building blocks for chemical glycosylation, O-benzoxazolyl (OBox) and 3,3-difluoro-3H-indol-2-yl (OFox) imidates. Based on our observation that the OFox leaving group has the same structure before its introduction and after its departure, 3,3-difluoroxindole (HOFox) aglycone, we developed a new regenerative concept for chemical glycosylation. This method allows for performing glycosylation reactions in a conceptually novel way using catalytic amounts of reagents and activators. Further application of the regenerative concept to the HPLC-assisted synthesis on polymer support, an automated technology being developed in our laboratory, was complementary for refining all chemical aspects of both methods.