This volume provides readers with a better understanding of organogenesis in developmental biology and next-generation organ regenerative therapy. This book focuses on recent studies of organ regeneration from stem cells using in vitro 3D cell culture and manipulation. The chapters cover topics such as generation of a 3D retinal tissue formation; functional salivary gland regeneration; liver regeneration using cultures liver bud; and in vivo model of small intestine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Organ Regeneration: 3D Stem Cell Culture and Manipulation is a valuable resource for scientists and researchers who are interested in this field.
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Hair disorders have become a central social and psychological issue and patients now have increasing demands and expectations. Written by world-renowned experts, this lavishly illustrated book provides the latest scientific aspects of hair biology, up to date knowledge on hair diagnosis and treatment options as well as hair removal and restoration techniques. The content is divided into three sections: basic aspects of hair growth; hair and scalp disorders; and fotoepilation, surgery and hair cosmetics. In addition, coverage is enhanced with unique sections on hair in different ages and in art, on ethnic hair and in forensic investigations.
This textbook contains the latest advances and scientific knowledge from the leading experts in hair biology, hair disorders, and clinical trichology. The book consists of ten sections in which hair biology, hair genetics, hair diagnostics, hair loss types, pathogenesis, treatment options, and restoration techniques are discussed. This book also emphasizes on various genetic and nongenetic alopecia types, differential diagnosis, and the measurement of hair loss. One chapter of the book is devoted to natural products for hair care and treatment. We believe that this textbook will serve as a comprehensive guide to many physicians dealing with hair disorders in their clinical practice.
A microhistory in the vein of Salt and Cod exploring the biological, evolutionary, and cultural history of one of the world's most fascinating fibers. Most people don't give a second thought to the stuff on their head, but in Hair, Kurt Stenn — one of the world's foremost hair follicle experts — takes readers on a global journey through history, from fur merchant associations and sheep farms to medical clinics and patient support groups, to show the remarkable impact hair has had on human life. From a completely bald beauty queen with alopecia to the famed hair-hang circus act, Stenn weaves the history of hair through a variety of captivating examples, with sources varying from renaissance merchants’ diaries to interviews with wig makers, modern barbers, and more. In addition to expelling the biological basis and the evolutionary history of hair, the fiber is put into context: hair in history (as tied to textile mills and merchant associations), hair as a construct for cultural and self-identity, hair in the arts (as the material for artist's brushes and musical instruments), hair as commodity (used for everything from the inner lining of tennis balls to an absorbent to clean up oil spills), and hair as evidence in criminology. Perfect for fans of Mark Kurlansky, Hair is a compelling read based solidly in historical and scientific research that will delight any reader who wants to know more about the world around them.
The Biology of Hair Growth is based on a conference on The Biology of Hair Growth, sponsored by the British Society for Research on Ageing, held at the Royal College of Surgeons, in London, 7-9 August 1957. The papers presented at this conference, and a few others, have been gathered in this book to serve as a source reference for all those interested in research on hair and hair growth. The application of modern methods in histology, cytology, histochemistry, physiology, electron microscopy, the use of radioactive isotopes, and modern biochemical techniques have given greater insight into the phenomena of growth and differentiation of hair follicles than ever before. The book opens with a chapter on the embryology of hair. Separate chapters follow on the anatomy and histochemistry of the hair follicle; the electron microscopy of keratinized tissues; the chemistry of keratinization; the mitotic activity of the follicle; and the the vascularity and patterns of growth of hair follicles. Subsequent chapters deal with behavior of pigment cells and epithelial cells in the hair follicle; the nature of hair pigment; the effects of nutrition on hair growth; and effects of chemical agents, ionizing radiation, and particular illnesses on hair roots.
Hair is a major component of the body's tissue system that contributes to the individual's make up and confers a large degree of personal identity. Apart from its visible façade, hair also has a functional role. It has an unique structure and complex molecular development. The very nature of hair makes it a suitable marker for the prognosis of disease. Hair can also be used to screen for toxins and changes in the diet. However, there are currently no suitable publications available that describe hair in a rational scientific context. This handbook provides an academic approach to hair in health and disease. Divided into five sections the Handbook of Hair in Health and Disease provides an insight into hair growth and loss, molecular and cellular biology of hair, dietary toxicity and pathological history, diseases and treatments of hair, as well as shampoos and conditioners. Unique features of each chapter in this volume include relevant and useful 'Key facts' which highlight interesting or important findings of the specific subjects and 'Summary points' that will give a clear overview of the subjects treated in each chapter. The Handbook of Hair in Health and Disease will be essential to a variety of users, such as trichologists, doctors and nurses and all those interested or working within the area of hair health. This includes nutritionists and dieticians, scientific beauticians, health workers and practitioners, college and university lecturers and undergraduate and graduate students.
This reference volume conveys complete understanding and management of Androgenetic Alopecia and Female Pattern Hair Loss (AGA/FPHL). These are probably the most common adult (18-50 yrs.) health disorders besides dental caries, accounting for over 98% of hair loss cases in males and over 70% cases in females. The present volume, the first of three related volumes, is structured in 4 sections: 22 dedicated chapters, ranging from basic science (Biology, Anatomy, Physiology, Embryology), the etiology of adult, childhood & adolescent AGA/FPHL, diagnostic steps and evaluation, to related disorders and comorbidities. For the first time in the scientific literature, all pathogenic contributors of AGA/FPHL, including micro-inflammation, scalp vascularization, biochemical stress, aging, solar radiation, and the sebaceous gland, are examined in comprehensive, dedicated chapters. The effects of every hormone on AGA/FPHL, as well as the psychological impact of the condition, are explored in depth. An extensive chapter on childhood and adolescent AGA/FPHL, a more common than previously thought condition, is another unique feature. Finally, two extremely detailed sections are included on the pathogenic links of AGA/FPHL to life-threatening comorbidities: cardiovascular disease, metabolic syndrome, hypertension, insulin resistance, and prostatic disorders, with suggested guidelines on how to save lives of balding patients by adopting early screening strategies. In providing a fully updated, thorough guide to this popular topic, this richly illustrated volume (over 200 figures, tables, and algorithms) offers the latest, evidence-based information on every aspect of AGA/FPHL causing hair loss to countless patients. Each subject is addressed according to learning and clinical needs, and the presented information is supported by a wealth of peer-reviewed papers. Every aspect of this condition is considered, including biology, diagnosis, etiology, from drug treatment, the influence of nutrition, lifestyle and food supplements, to related disorders, surgical hair restoration, hair care, and future treatment options. This handbook will be an invaluable conveying best management standards to readers, whether experienced practitioners, clinicians, dermatologists, surgeons or researchers interested in hair restoration.
Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.
