"These guidelines explain, in detail, how notifiers determine whether a substance is subject to notification under the New Substances Notification Regulations and identify the applicable information requirements. In addition, these guidelines provide step-by-step instructions on the completion of a New Substances Notification (NSN) Form, elaborate the technical considerations of the information requirements, identify appropriate test procedures and practices, and outline how confidential information should be treated. These guidelines conclude with an explanation of how Environment Canada and Health and Welfare Canada assess the information submitted in an NSN, and what the consequences of assessment decisions are on notifiers"--Abstract.
The first and only guidance document to help applicants from chemical manufacturers obtain approval to synthesize and manufacture a chemical compound. Written by two EPA scientists, it provides coverage of chemical information needed for risk assessment to satisfy the requirements of the PMN review process and comply with the Toxic Substance Control Act.
"These guidelines explain, in detail, how notifiers determine whether a substance is subject to notification under the New Substances Notification Regulations and identify the applicable information requirements. In addition, these guidelines provide step-by-step instructions on the completion of a New Substances Notification (NSN) Form, elaborate the technical considerations of the information requirements, identify appropriate test procedures and practices, and outline how confidential information should be treated. These guidelines conclude with an explanation of how Environment Canada and Health and Welfare Canada assess the information submitted in an NSN, and what the consequences of assessment decisions are on notifiers"--Abstract.
The method described in this Test Guideline is based on soil column chromatography in disturbed soil. Two types of experiments are performed to determine (i) the leaching potential of the test substance, and (ii) the leaching potential of ...
Plastics have developed into the most important class of packaging materials. Their relative impermeability for substances from the surroundings has great influence on the shelf life and the quality of the packed goods. At the same time the interaction between the contents and the various components of the packaging plays a decisive role. This particular book is indispensable in the search for the optimal plastic packaging. It facilitates the estimation of the influence on the goods which come from the surroundings and from the packaging. The authors do not restrict themselves only to the description of the phenomena of diffusion or transport in theory, but they show what they mean for practical applications. Food represents the central theme as main area of application for plastic packaging. It can be considered to be the "model substance" and the findings are to be applied to many other products and systems. The main rules and regulations for food packaging of the European Community and the United States are presented in this book. Furthermore the authors emphasize the testing methods for proving the mass transport and the sensory check of the quality of the products.
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.