Genomic Profiling of Familial Early-age of Onset Breast Cancer
Author: Andrew Seto
Publisher:
Published: 2015
Total Pages:
ISBN-13:
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Mammography and Beyond
Author: National Research Council
Publisher: National Academies Press
Published: 2001-06-04
Total Pages: 34
ISBN-13: 0309075505
DOWNLOAD EBOOKX-ray mammography screening is the current mainstay for early breast cancer detection. It has been proven to detect breast cancer at an earlier stage and to reduce the number of women dying from the disease. However, it has a number of limitations. These current limitations in early breast cancer detection technology are driving a surge of new technological developments, from modifications of x-ray mammography such as computer programs that can indicate suspicious areas, to newer methods of detection such as magnetic resonance imaging (MRI) or biochemical tests on breast fluids. To explore the merits and drawbacks of these new breast cancer detection techniques, the Institute of Medicine of the National Academy of Sciences convened a committee of experts. During its year of operation, the committee examined the peer-reviewed literature, consulted with other experts in the field, and held two public workshops. In addition to identifying promising new technologies for early detection, the committee explored potential barriers that might prevent the development of new detection methods and their common usage. Such barriers could include lack of funding from agencies that support research and lack of investment in the commercial sector; complicated, inconsistent, or unpredictable federal regulations; inadequate insurance reimbursement; and limited access to or unacceptability of breast cancer detection technology for women and their doctors. Based on the findings of their study, the committee prepared a report entitled Mammography and Beyond: Developing Technology for Early Detection of Breast Cancer, which was published in the spring of 2001. This is a non-technical summary of that report.
Identification of Novel Genetic Gains and Losses in Early Age of Onset Breast Cancer by Array Comparative Genomic Hybridization
Author: Duygu Acar
Publisher:
Published: 2007
Total Pages: 196
ISBN-13: 9780494402764
DOWNLOAD EBOOKBreast cancer represents the most frequent female cancer. Hereditary breast cancers usually arise at an earlier age and are often multifocal or bilateral. Early age of onset breast carcinomas generally exhibit more aggressive features. Moreover, they are usually associated with poorer prognosis. Gene amplifications and deletions frequently contribute to tumorigenesis. This study aimed to identify and characterize specific regions of alteration that are associated with each subgroup; early age of onset and familial breast tumors by array comparative genomic hybridization (aCGH). A number of alterations, many of which have been shown in breast cancer through conventional CGH were identified. Several gains including 8q24, 11g12-q13, 16p, 17q12 and 19g13.2 were studied and validated by Real time PCR. Moreover, a gain on chromosome 16p was narrowed down to 16p12.3. In this region ARL6IP1, an inhibitor of apoptosis, was found to be amplified in 18% of tumors and may represent a candidate oncogene.
Understanding Breast Cancer Genetics
Author: Barbara T. Zimmerman
Publisher: Univ. Press of Mississippi
Published: 2004
Total Pages: 142
ISBN-13: 9781578065783
DOWNLOAD EBOOKHealth & Sickness -- Consumer Health This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually. Why are some women more vulnerable than others? The interplay between genetics and environment is suspected. Thus this book for general readers will help them understand the genetic bases of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on. Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered. Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included. Barbara T. Zimmerman did her graduate work in experimental pathology and her post-doctoral research in the cellular and molecular processes of disease. Widely published, she is the manager of the Denver-based firm Biomedical Communication and Consulting.
Accomplishments, Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition
Author: Paolo Peterlongo
Publisher: Frontiers Media SA
Published: 2019-10-16
Total Pages: 141
ISBN-13: 288963132X
DOWNLOAD EBOOKIn this eBook, we described the accomplishments, collaborative projects and future initiatives in the field of breast cancer genetic predisposition. More specifically, the articles included focused on aspects such as mutation screening in unexplored populations, identification and characterization of novel predisposing genes and mutations, and population screening.
Genomic Profiling of Hereditary Breast Cancer
Author: Lars van Brakel Andersen
Publisher:
Published: 2019
Total Pages: 188
ISBN-13:
DOWNLOAD EBOOKGenetic and Environmental Influences on Early-onset Breast Cancer Prognosis:Using Genome-wide Association Data to Assess Gene-environment Interactio N
Author: Stephanie Claire Melkonian
Publisher:
Published: 2013
Total Pages: 141
ISBN-13: 9781303229039
DOWNLOAD EBOOKIn the second study of this dissertation (Chapter 3) I evaluated interactions of pregnancy (ever/never), age at menarche (
Breast Cancer Research. Ageing as Predisposing Factor
Author: Gabby Ian
Publisher: GRIN Verlag
Published: 2021-09-08
Total Pages: 34
ISBN-13: 3346482812
DOWNLOAD EBOOKDiploma Thesis from the year 2018 in the subject Health - Nursing Science - Geriatric Care, grade: A, Kenyatta University, language: English, abstract: This work investigates whether age is among the predisposing factors for breast cancer. Breast cancer is heterogeneous malignant cells whose specific age profiles exponentially increases until menopause after which it rises gently slowly thereby reflecting the superimposition of the early and late onset rates of breast cancer. The early onset breast cancers represent mainly the untimely life transforming or inherited consequences on the undeveloped epithelium, while late-onset breast cancers in most cases are likely to follow an extended exposure to supporting stimulus of vulnerable epithelium, which has botched to age normally. Biomarker studies and clinical observations indicates that the latter staged breast cancer types often develop slowly and are less biologically aggressive compared to the early staged breast cancers despite being under the control of hormone receptors such as growth factor receptor abbreviated as (HER2) and estrogen receptor (ER), expressions hence supporting the conclusion that breast cancer biology is age dependent. Approximately twelve percent of women across the globe in the current society are annually affected by breast cancer. Moreover, while breast cancer incidence increases with age advancement, patients of younger age at diagnosis are largely associated with increase in the mortality rate. This research discusses most of the age-related factors, which affect the identification or diagnosis, treatment, and management of breast cancer incidence; examining main concepts and exploring vital areas, which calls for additional research. Ageing as a predisposing factor for breast cancer will be examined in connection to diagnosis and treatment with special reference to nodal status, hormone factors, breast cancer subtypes and genetic status. Further, although narrowly, the study will also touch on the future expectations of breast cancer identification and treatment through examination of some rising potential technologies and breast cancer tests like the miRNA.
Fast Facts: Comprehensive Genomic Profiling
Author: Bernardo L. Rapoport
Publisher: Karger Medical and Scientific Publishers
Published: 2020-10-20
Total Pages: 109
ISBN-13: 3318068187
DOWNLOAD EBOOKCancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
Targeted Therapies for Lung Cancer
Author: Ravi Salgia
Publisher: Springer
Published: 2019-06-26
Total Pages: 238
ISBN-13: 3030178323
DOWNLOAD EBOOKThis book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
