Genetically Modified and other Innovative Vector Control Technologies

Genetically Modified and other Innovative Vector Control Technologies

Author: Brij Kishore Tyagi

Publisher: Springer Nature

Published: 2022-01-01

Total Pages: 455

ISBN-13: 9811629641

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This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.


Genetic Control of Malaria and Dengue

Genetic Control of Malaria and Dengue

Author: Zach N. Adelman

Publisher: Academic Press

Published: 2015-10-15

Total Pages: 487

ISBN-13: 0128004053

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Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. - Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission - Provides a summary of the concepts of both population suppression and population replacement - Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies


Genetically Modified and Other Innovative Vector Control Technologies

Genetically Modified and Other Innovative Vector Control Technologies

Author: Brij Kishore Tyagi

Publisher:

Published: 2021

Total Pages: 0

ISBN-13: 9789811629655

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This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.


Genetically Modified Mosquitoes for Malaria Control

Genetically Modified Mosquitoes for Malaria Control

Author: Christophe Boete

Publisher: CRC Press

Published: 2006-07-15

Total Pages: 198

ISBN-13:

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This book describes the epidemiological and evolutionary consequences of the use of genetically modified (GM) mosquitoes as well as research orientations and ethical issues concerning the use of GM mosquitoes. It also includes discussion on transgenic mosquitoes for malaria control.


Gene Drives on the Horizon

Gene Drives on the Horizon

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-08-28

Total Pages: 231

ISBN-13: 0309437873

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Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.


Safety of Genetically Engineered Foods

Safety of Genetically Engineered Foods

Author: National Research Council

Publisher: National Academies Press

Published: 2004-07-08

Total Pages: 254

ISBN-13: 0309166152

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Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.


Innovative Strategies for Vector Control

Innovative Strategies for Vector Control

Author: Constantianus J.M. Koenraadt

Publisher: Brill Wageningen Academic

Published: 2021-03-04

Total Pages: 0

ISBN-13: 9789086863440

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This 6th volume of the ECVD series reflects on the progress of GVCR. The introduction and concluding chapters of the book have been written in collaboration with WHO.


Genetically Engineered Crops

Genetically Engineered Crops

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2017-01-28

Total Pages: 607

ISBN-13: 0309437385

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Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.


Dengue and Zika: Control and Antiviral Treatment Strategies

Dengue and Zika: Control and Antiviral Treatment Strategies

Author: Rolf Hilgenfeld

Publisher: Springer

Published: 2018-05-29

Total Pages: 375

ISBN-13: 981108727X

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This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.


Mosquito Research

Mosquito Research

Author: Henry Puerta-Guardo

Publisher: BoD – Books on Demand

Published: 2023-01-04

Total Pages: 284

ISBN-13: 1803558520

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With around 3,500 species identified so far, mosquitoes can be found in virtually every environment and continent around the globe. Blood-feeding biters (e.g., Anopheles, Culex, Aedes, Ochlerotatus, and Mansonia) are among the most influential vectors for harboring and transmitting mosquito-borne diseases (MBDs) such as Zika, Japanese encephalitis, West Nile fever, dengue fever, yellow fever, and malaria, among other diseases. More than 700 million human infections and 725,000 deaths occur every year. Mosquitoes are increasing in number worldwide, yet there are still no effective vaccines or prevention strategies. Thus, traditional vector control strategies remain the most common ways to combat these diseases. Despite this, MBDs linger as one of the major challenges for public health and vector control programs at both global and local levels. This book provides a comprehensive overview of MBDs and vector control strategies.