Modeling the Psychopathological Dimensions of Schizophrenia

Modeling the Psychopathological Dimensions of Schizophrenia

Author: Mikhail Pletnikov

Publisher: Academic Press

Published: 2015-11-05

Total Pages: 550

ISBN-13: 012801184X

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Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader's understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. - Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models - Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia - Edited and authored by leading researchers in the field of schizophrenia and related psychoses


A Clinical Introduction to Psychosis

A Clinical Introduction to Psychosis

Author: Johanna C. Badcock

Publisher: Academic Press

Published: 2019-10-19

Total Pages: 736

ISBN-13: 0128150130

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This practical guide outlines the latest advances in understanding and treating psychotic symptoms and disorders, articulating step-by-step the clinical skills and knowledge required to effectively treat this patient population. A Clinical Introduction to Psychosis takes an evidence-based approach that encourages a wider perspective on clinical practice, with chapters covering stigma and bias, cultural factors, the importance of social functioning, physical health, sleep, and more. A broad array of treatment modalities are discussed, including cognitive behavioral therapy, cognitive remediation, psychosocial interventions, trauma-informed therapies, and recovery-oriented practice. The book also provides a concise overview of the latest advances regarding cognitive profiles in people with psychotic disorders, the developmental progression of cognitive abilities, and the clinical relevance of cognitive dysfunction. The book additionally familiarizes readers with issues and controversies surrounding diagnostic classification, transdiagnostic expression, and dimensional assessment of symptoms in psychosis. - Provides treatment and assessment methods for psychotic symptoms and disorders - Looks at how psychosis develops and the impact of stigma on clinicians and clients - Studies the links between trauma, PTSD, and psychosis, as well as sleep and psychosis - Covers digital technologies for treating and assessing psychosis - Outlines strategies for treating visual and auditory hallucinations - Examines how to incorporate consumer and clinician perspectives in clinical practice


Principles of Psychiatric Genetics

Principles of Psychiatric Genetics

Author: John I. Nurnberger

Publisher: Cambridge University Press

Published: 2012-09-13

Total Pages: 415

ISBN-13: 0521896495

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A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.


The New Genetics of Mental Illness

The New Genetics of Mental Illness

Author: Peter McGuffin

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 317

ISBN-13: 1483164276

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The New Genetics of Mental Illness is a collection of papers that discusses the advancement of molecular biology in the context of psychiatry. The book presents papers that are organized thematically. The text first discusses the basics of biology and quantitative models, and then proceeds to covering linkage analysis. Next, the book deals with various mental disorders, including schizophrenia, eating disorders, and developmental disorders. The remaining materials turn their attention to dementia and Huntington's disease. The book will be of great use to researchers and practitioners of behavioral sciences, such as psychology and psychiatry.


Models of Madness

Models of Madness

Author: Dr John Read

Publisher: Routledge

Published: 2013-06-19

Total Pages: 489

ISBN-13: 1134055021

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Are hallucinations and delusions really symptoms of an illness called ‘schizophrenia’? Are mental health problems really caused by chemical imbalances and genetic predispositions? Are psychiatric drugs as effective and safe as the drug companies claim? Is madness preventable? This second edition of Models of Madness challenges those who hold to simplistic, pessimistic and often damaging theories and treatments of madness. In particular it challenges beliefs that madness can be explained without reference to social causes and challenges the excessive preoccupation with chemical imbalances and genetic predispositions as causes of human misery, including the conditions that are given the name 'schizophrenia'. This edition updates the now extensive body of research showing that hallucinations, delusions etc. are best understood as reactions to adverse life events and that psychological and social approaches to helping are more effective and far safer than psychiatric drugs and electroshock treatment. A new final chapter discusses why such a damaging ideology has come to dominate mental health and, most importantly, how to change that. Models of Madness is divided into three sections: Section One provides a history of madness, including examples of violence against the ‘mentally ill’, before critiquing the theories and treatments of contemporary biological psychiatry and documenting the corrupting influence of drug companies. Section Two summarises the research showing that hallucinations, delusions etc. are primarily caused by adverse life events (eg. parental loss, bullying, abuse and neglect in childhood, poverty, etc) and can be understood using psychological models ranging from cognitive to psychodynamic. Section Three presents the evidence for a range of effective psychological and social approaches to treatment, from cognitive and family therapy to primary prevention. This book brings together thirty-seven contributors from ten countries and a wide range of scientific disciplines. It provides an evidence-based, optimistic antidote to the pessimism of biological psychiatry. Models of Madness will be essential reading for all involved in mental health, including service users, family members, service managers, policy makers, nurses, clinical psychologists, psychiatrists, psychotherapists, counsellors, psychoanalysts, social workers, occupational therapists, art therapists.


Genetic Models of Schizophrenia

Genetic Models of Schizophrenia

Author: Akira Sawa

Publisher: Elsevier

Published: 2009-11-10

Total Pages: 142

ISBN-13: 0080962238

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This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, and neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.


Models of Madness

Models of Madness

Author: John Read

Publisher: Routledge

Published: 2004-08-02

Total Pages: 398

ISBN-13: 1135445087

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Models of Madness shows that hallucinations and delusions are understandable reactions to life events and circumstances rather than symptoms of a supposed genetic predisposition or biological disturbance. International contributors: * critique the 'medical model' of madness * examine the dominance of the 'illness' approach to understanding madness from historical and economic perspectives * document the role of drug companies * outline the alternative to drug based solutions * identify the urgency and possibility of prevention of madness. Models of Madness promotes a more humane and effective response to treating severely distressed people that will prove essential reading for psychiatrists and clinical psychologists and of great interest to all those who work in the mental health service. This book forms part of the International Society for the Psychological Treatment of Psychoses series edited by Brian Martindale.


Genetic Models of Schizophrenia

Genetic Models of Schizophrenia

Author: Akira Sawa

Publisher: Elsevier Science

Published: 2009-12-28

Total Pages: 144

ISBN-13: 9780444534309

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This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, and neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.


Secondary Schizophrenia

Secondary Schizophrenia

Author: Perminder S. Sachdev

Publisher: Cambridge University Press

Published: 2010-02-04

Total Pages:

ISBN-13: 1139485229

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Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases.


Schizophrenia

Schizophrenia

Author: Irving I. Gottesman

Publisher: CUP Archive

Published: 1982-06-30

Total Pages: 276

ISBN-13: 9780521295598

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