Genetic and Epigenetic Insights Into the Developmental Origins of Health and Disease
Author: Tesfaye B. Mersha
Publisher: Frontiers Media SA
Published: 2022-04-21
Total Pages: 83
ISBN-13: 2889747476
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Epigenetics in Health and Disease
Author: Igor Kovalchuk
Publisher: FT Press
Published: 2012
Total Pages: 609
ISBN-13: 013259708X
DOWNLOAD EBOOK"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Page 4 of cover.
Early Life Origins of Human Health and Disease
Author: John P. Newnham
Publisher: Karger Medical and Scientific Publishers
Published: 2009-01-01
Total Pages: 233
ISBN-13: 380559139X
DOWNLOAD EBOOKThere is compelling evidence that many of the risks leading to the most frequent chronic diseases in adulthood originate in the earliest stages of life. Adverse environmental conditions in utero and during infancy can lead to negative health effects during the subsequent lifetime of the exposed individual.This book offers precious insights into the latest concepts and results from epidemiologic, clinical and basic studies in this burgeoning area of health care. The developmental origins of various diseases such as diabetes, obesity and cancer are examined, as well as the early programming of reproductive health and different organs. Attention is given to the impact of environmental factors such as nutrition and pollution, and the mediating genetic and epigenetic pathways are reviewed. A crucial point under discussion is the concept of environmental insults adversely affecting not only the exposed persons, but also their descendants. In addition, the economic consequences of a suboptimal start to life and the importance of preventive measures are stressed.This publication is of great value to anyone interested in health care, notably to specialists in obstetrics, pediatrics, internal medicine, obesity, diabetes and heart disease.
The Epigenome and Developmental Origins of Health and Disease
Author: Cheryl S. Rosenfeld
Publisher: Academic Press
Published: 2015-10-10
Total Pages: 562
ISBN-13: 0128016728
DOWNLOAD EBOOKWinner of 2016 BMA Medical Award for Basic and Clinical Sciences The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field
Developmental Origins of Health and Disease
Author: Peter Gluckman
Publisher: Cambridge University Press
Published: 2006-04-20
Total Pages: 542
ISBN-13: 9780521847438
DOWNLOAD EBOOKThis landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.
Investigating the Human Genome
Author: Moyra Smith
Publisher: Ft Press
Published: 2011
Total Pages: 216
ISBN-13: 9780132168144
DOWNLOAD EBOOKLeading medical genetics scholar Moyra Smith reviews current prospects and progress in medical genetics and genomics, arising from the growth of gene mapping and Human Genome sequencing. She addresses recent investigations into human origins, migrations, and diversity; psychiatric diseases; Alzheimer’s, Parkinsonism, and ALS; protein misfolding; gene-environment interactions; mRNA; epigenetics, and much more
Epigenetics, Development, Ecology and Evolution
Author: Luis María Vaschetto
Publisher: Springer Nature
Published: 2022-10-13
Total Pages: 239
ISBN-13: 303113771X
DOWNLOAD EBOOKEpigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.
Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease
Author: Fumihiro Sata
Publisher: Springer
Published: 2018-12-11
Total Pages: 217
ISBN-13: 9811321949
DOWNLOAD EBOOKThis book reviews public health activities such as awareness campaigns, health education, and strategies for health policy based on recent epidemiological studies that provide insights into epigenetic processes caused by environmental factors and developmental plasticity. It provides the latest concepts and findings on the public health aspects of Developmental Origins of Health and Disease (DOHaD) research regarding early prevention of non-communicable diseases (NCDs). Attention is especially paid to key issues, including strategies for the effective prevention of NCDs in developmental stages of life and younger generations rather than in adults and the elderly. Public Health Aspects in Developmental Origins of Health and Disease (DOHaD) is structured in two parts; the first focuses on general remarks reviewing specific recommendations, practical methods and protocols, and future goals regarding public health aspects, while the second presents brief profiles of individual cohorts and consortia studies. This collection will benefit both new and established researchers, as well as students in the fields of epidemiology, clinical medicine, nutrition, education, and public health who are seeking comprehensive information on DOHaD and preemptive medicine.
Epigenetics and Public Policy
Author: Shea K. Robison
Publisher:
Published: 2023
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOKThe exciting field of epigenetics offers novel and unanticipated science-based insights into human origins and development. This book presents one of the first detailed examinations of the political implications of epigenetics. Epigenetics-the study of internal and environmental factors that affect how genes are turned on or off and how cells read those genes-is a rapidly emerging science akin to genetics that introduces a number of novel and unexpected biological explanations of human origins and development. It also poses fundamental challenges to many of the assumptions of the prevailing science of genetics. When science changes, how does public policy respond? This book comprehensively considers the political implications of the emerging science of epigenetics in specific policy domains, addressing the intersections of epigenetics with cancer, obesity, the environment, and the law. Author Shea K. Robison carefully navigates the messy history of genetics and epigenetics in order to explore what changes in public policy might come in the age of a new scientific frontier. Readers will understand how new findings in epigenetic research and increased acceptance of epigenetic science may lead to paradigm shifts in cancer prevention and treatment, significantly different policy solutions for combating obesity, and revised statutes of limitations and laws regarding civil and corporate liability and wrongful life.
Developmental Origins of Health and Disease (DOHaD)
Author: Takeo Kubota
Publisher: Springer
Published: 2018-07-12
Total Pages: 0
ISBN-13: 9789811055256
DOWNLOAD EBOOKThis book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
