This volume brings together noted scientists who study presbycusis from the perspective of complementary disciplines, for a review of the current state of knowledge on the aging auditory system. Age-related hearing loss (ARHL) is one of the top three most common chronic health conditions affecting individuals aged 65 years and older. The high prevalence of age-related hearing loss compels audiologists, otolaryngologists, and auditory neuroscientists alike to understand the neural, genetic and molecular mechanisms underlying this disorder. A comprehensive understanding of these factors is needed so that effective prevention, intervention, and rehabilitative strategies can be developed to ameliorate the myriad of behavioral manifestations.
This book starts by discussing the anatomy and physiology of the inner ear. Then it delves deeper into hearing loss, how to prevent it, and the genetics behind it. How to manage related symptoms such as hyperacusis and tinnitus is also discussed as well as current medical treatments and new immunological approaches to treating hearing loss. Furthermore, the most up-to-date hearing devices such as digital hearing aids, implantable bone conduction devices, and cochlear implants are discussed at great length.Each chapter opens with an overview of its main concepts, is filled with various illustrations and tables to aid in the explanation of the text, and concludes with a list of the pertinent citations. This fascinating book is especially aimed at people with hearing loss and includes pertinent information on devices assisting them in hearing. This unique book that is addressed to both patients and professionals, is an easy to read book and will update them about the management of hearing loss in 2023 and beyond.
Heredity, either alone or in combination with environmental factors, is the most prominent underlying cause of hearing impairment. Thanks in large part to positional cloning techniques, scientists have identified nearly 100 gene loci implicated in hearing loss since 1995-an extraordinarily rapid rate of gene identification. Genetic Hearing Loss branches into syndromic and nonsyndromic categorical directions in its coverage of the genetics behind hearing loss. Authored by 60 internationally recognized researchers, the book describes the normal development of the ear, updates the classification and epidemiology of hearing loss, and surveys the usage of audiometric tests and diagnostic medical examinations.
Hearing loss is the most common form of sensory impairment in humans, affecting 360 million persons worldwide. In parallel, tinnitus disorder, the perception of a phantom sound often described as a ringing or buzzing, affects around 10–15% of the general population and interferes with daily life. Hyperacusis, defined as a hypersensitivity to moderate-intensity sounds often co-occurs with tinnitus suggesting a common mechanism of dysfunction for these two perceptual disorders. Whereas some drug candidates are in the process of being developed, nowadays no effective treatment exists to cure hearing loss and tinnitus. The topic of this book was selected with the goal of emphasizing mechanisms that induce hearing loss and tinnitus which lead the selection of promising targets for hearing disorder treatment. Hair cells (HC) are the sensory cells of the inner ear required for both auditory and vestibular functions in all vertebrates. HC are progressively lost during ageing and they are in addition sensitive to physical and acoustic traumas, infectious diseases and chemicals present in commonly used treatments such as anticancer, antimalarial or antibiotics. As adult mammals--including humans--cannot regenerate dead HC, all the possible injury could result in irreversible and permanent hearing loss. It has been shown, however, that a limited capacity to regenerate HC exists in mouse at an early stage of development. The regenerative capacity of HC then appears simply “repressed” in adult mammals, and one could expect it will be possible to re-activate it with an appropriate therapeutic approach which is still to be defined. Immune-mediated inner ear disease has been introduced and accepted as one SNHL pathophysiology; it responds to immunosuppressive therapy and is one of the few reversible forms of bilateral SNHL. Macrophages are always present in the spiral ligament of the lateral wall and are activated in response to various types of stimuli, including noise exposure, ischemia, mitochondrial damage, and surgical stress. Recent studies have also revealed another type of immune cell, called perivascular melanocyte-like macrophages (PVM/Ms), in the stria vascularis. The book will include a review of inflammatory/immune cells in the cochlear lateral wall, the pathways involved in cochlear damage and their potential as therapeutic targets. The final chapter provides an overview of current animal model of tinnitus and hyperacusis. Nowadays no effective treatment exists to cure tinnitus and hyperacusis. One major obstacle to arises from the fact that tinnitus is a subjective phenomenon, the only possible diagnosis relies on self-reports of the subjects. The main constraint of the use of animal models is the subjective character of tinnitus. This chapter describe the advancement in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis.
Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. - Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors - Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement - Demonstrates noninvasive imaging of adenovirus-mediated gene transfer - Discusses utility of adenoviral vectors in animal disease models - Considers Federal Drug Administration regulations for human clinical trials
The Senses: A Comprehensive Reference, Second Edition, Seven Volume Set is a comprehensive reference work covering the range of topics that constitute current knowledge of the neural mechanisms underlying the different senses. This important work provides the most up-to-date, cutting-edge, comprehensive reference combining volumes on all major sensory modalities in one set. Offering 264 chapters from a distinguished team of international experts, The Senses lays out current knowledge on the anatomy, physiology, and molecular biology of sensory organs, in a collection of comprehensive chapters spanning 4 volumes. Topics covered include the perception, psychophysics, and higher order processing of sensory information, as well as disorders and new diagnostic and treatment methods. Written for a wide audience, this reference work provides students, scholars, medical doctors, as well as anyone interested in neuroscience, a comprehensive overview of the knowledge accumulated on the function of sense organs, sensory systems, and how the brain processes sensory input. As with the first edition, contributions from leading scholars from around the world will ensure The Senses offers a truly international portrait of sensory physiology. The set is the definitive reference on sensory neuroscience and provides the ultimate entry point into the review and original literature in Sensory Neuroscience enabling students and scientists to delve into the subject and deepen their knowledge. All-inclusive coverage of topics: updated edition offers readers the only current reference available covering neurobiology, physiology, anatomy, and molecular biology of sense organs and the processing of sensory information in the brain Authoritative content: world-leading contributors provide readers with a reputable, dynamic and authoritative account of the topics under discussion Comprehensive-style content: in-depth, complex coverage of topics offers students at upper undergraduate level and above full insight into topics under discussion
Sotos syndrome, characterized by its distinctive physical features, cognitive challenges, and various health concerns, presents unique psychological and emotional hurdles for affected individuals and their families. This book, "Psychological Support by Cognitive Behavioral Therapy for Sotos Syndrome," aims to address these challenges through the lens of Cognitive Behavioral Therapy (CBT). In recent years, there has been growing recognition of the profound impact that psychological support can have on individuals living with genetic conditions. Many families navigating the complexities of Sotos syndrome often grapple with feelings of isolation, uncertainty, and distress. This book seeks to bridge that gap by providing valuable insights, practical tools, and therapeutic strategies tailored to meet the needs of those affected by this syndrome. The foundation of this work lies in the integration of psychological theory, genetic understanding, and therapeutic practices. Each chapter delves into critical topics—from understanding the biological and genetic underpinnings of Sotos syndrome to exploring the various therapeutic approaches available. By combining scientific knowledge with practical applications, we hope to empower readers to engage with the psychological aspects of living with Sotos syndrome in a constructive manner. Cognitive Behavioral Therapy has proven to be an effective intervention for addressing a range of emotional and psychological issues. It focuses on the connection between thoughts, feelings, and behaviors, enabling individuals to challenge negative thought patterns and develop healthier coping strategies. This book not only introduces the principles of CBT but also emphasizes its specific application to the unique experiences of individuals with Sotos syndrome. Moreover, this book acknowledges the vital role of families, caregivers, and healthcare professionals in the therapeutic process. Through the inclusion of personalized therapeutic approaches and tools, we aim to create a comprehensive resource that fosters collaboration among all parties involved in the care and support of those affected by Sotos syndrome. In closing, I would like to extend my heartfelt gratitude to all the individuals and families who have generously shared their stories and insights. Your resilience and courage continue to inspire us all. It is my hope that this book will serve as a guiding light, offering support, understanding, and practical strategies for navigating the emotional landscape of Sotos syndrome. Together, we can build a foundation for hope, healing, and a brighter future.
