Gender Differences in Metabolism

Gender Differences in Metabolism

Author: Mark Tarnopolsky

Publisher: CRC Press

Published: 2019-08-15

Total Pages: 354

ISBN-13: 1351080679

DOWNLOAD EBOOK

Gender Differences in Metabolism: Practical and Nutritional Implications is the first book to successfully integrate nutritional science, exercise physiology/medicine, and metabolism. This volume explores recent scientific evidence that male and female athletes exhibit different metabolic responses and, therefore, differ in their nutritional needs and advice. Anyone interested in good health, exercise, and nutrition will find this book a valuable resource.


Pancreatic Islet Biology

Pancreatic Islet Biology

Author: Anandwardhan A. Hardikar

Publisher: Springer

Published: 2016-10-25

Total Pages: 332

ISBN-13: 3319453076

DOWNLOAD EBOOK

This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.


Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Author: Franck Mauvais-Jarvis

Publisher: Springer

Published: 2017-12-08

Total Pages: 630

ISBN-13: 3319701789

DOWNLOAD EBOOK

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.


Oxford Textbook of Endocrinology and Diabetes

Oxford Textbook of Endocrinology and Diabetes

Author: John A.H. Wass

Publisher: Oxford University Press, USA

Published: 2011-07-28

Total Pages: 2158

ISBN-13: 0199235295

DOWNLOAD EBOOK

Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.


Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Author: H.Gerhard Vogel

Publisher: Springer Science & Business Media

Published: 2010-12-15

Total Pages: 576

ISBN-13: 3540898905

DOWNLOAD EBOOK

Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".


Exploring the Biological Contributions to Human Health

Exploring the Biological Contributions to Human Health

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-07-02

Total Pages: 287

ISBN-13: 0309132975

DOWNLOAD EBOOK

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.


Metabolic Response to Food Restriction in Military-Eligible Women, with a Gender Comparison

Metabolic Response to Food Restriction in Military-Eligible Women, with a Gender Comparison

Author:

Publisher:

Published: 1996

Total Pages: 0

ISBN-13:

DOWNLOAD EBOOK

Two major series of investigations are being undertaken to explore the metabolic responses of women who meet military standards for body-weight and percent body-fat to the nutritional stressors of food restriction. A comparison of their responses is being made with those occurring in men, who also meet the standards established by the military. The first series (Series 1) has been devoted to the temporal (progressive) changes in lipid, carbohydrate and protein metabolism that occur during a short-term (3 day) fasting period. Data obtained so far for leucine kinetics, nitrogen output, and fatty acid kinetics do not reveal any significant differences, either qualitatively or quantitatively in the metabolic response to an acute total food lack in women versus men. This series of studies will be completed pending further analysis of samples obtained. Work is now underway on the second set of studies. The first phase of this 3-week hypercaloric intake/metabolic study involves the participation of both women and men who receive a hypocaloric diet for 21 days to achieve a 900 Kcal daily dietary deficit that is based on an equal restriction of both lipid and carbohydrate but with keeping protein content at a relatively generous intake of 1.2 g/kg/day. Body composition, metabolic and physical and mental performance changes are being monitored to assess whether there are gender differences to partial and more prolonged energy restriction.


Sports Endocrinology

Sports Endocrinology

Author: F. Lanfranco

Publisher: Karger Medical and Scientific Publishers

Published: 2016-06-28

Total Pages: 182

ISBN-13: 3318058696

DOWNLOAD EBOOK

This book is an up-to-date, extensive overview of the effects of physical activity and training on endocrine function. It gives insights into a complex relationship by describing effects with respect to exercise performance, growth, development, and ageing. It includes discussions of the endocrine response depending on exercise mode, intensity, and duration as well as on gender, age, and fitness level. Additionally the book deals with the impact of environmental and psychological factors on endocrine level. A substantial part of Sports Endocrinology is devoted to the 'hot topic' of hormonal doping in sports. The properties of androgens, growth hormone, erythropoietin, and dietary supplements are highlighted. The use and abuse among professional and recreational athletes is discussed and specific methods of detection are presented and explained. All contributors are well-known experts in sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection, so this book is a must-read for every professional involved in the field.