Read and Download eBook Full
Author: Ajit Varki
Publisher: CSHL Press
Published: 1999
Total Pages: 694
ISBN-13: 9780879696818
DOWNLOAD EBOOKSugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Anatole A. Klyosov
Publisher: John Wiley & Sons
Published: 2008-10-17
Total Pages: 302
ISBN-13: 047037778X
DOWNLOAD EBOOKThe comprehensive guide to the current understanding of galectins and their promising potential in drug design This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes: * An overview of early galectin research * An explanation of the nature of galectins * A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell * An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity * A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance * An introduction to new approaches to designing galectin inhibitors This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.
Author: Anatole Klyosov
Publisher: OUP USA
Published: 2013-07-04
Total Pages: 0
ISBN-13: 9780841228801
DOWNLOAD EBOOKProvides discussion of the latest work in Galectins, stemming from the Symposium 'Galectin Functions and Therapeutics.'
Author: Armando Bartolazzi
Publisher: MDPI
Published: 2018-11-29
Total Pages: 351
ISBN-13: 3038974080
DOWNLOAD EBOOKIn the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell "glycome" in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, including RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response, and tumor growth and progression. It is not surprising, indeed, that a large number of studies on galectin-glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine. The aim of this Special Issue of IJMS is to collect selected contributions in the field reporting data, concepts, and new ideas, which have the potential to be translated in a clinical setting in the near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.
Author: Loriano Ballarin
Publisher: Academic Press
Published: 2016-04-08
Total Pages: 326
ISBN-13: 0128032537
DOWNLOAD EBOOKLessons in Immunity: From Single-cell Organisms to Mammals stems from the activity of the Italian Association of Developmental and Comparative Immunobiology (IADCI), represented by the editors. This book is presented as a series of short overviews that report on the current state of various relevant fields of immunobiology from an evolutionary perspective. The overviews are written by authors directly involved in the research, and most are members of the IADCI or have otherwise been involved in the related research for their respective overview. This publication offers scientists and teachers an easy and updated reference tool. Provides simple and updated reviews on the immunobiology of a wide spectrum of organisms, considered in an evolutionary context Focuses on both cells and humoral components of a variety of non-classical model organisms Offers in a single volume many contributions which can help with understanding the evolution of immune responses and the main adaptations in animal phyla Presents a valuable holistic cross-sectional approach for teaching immunology and its applications
Author: Sean R. Stowell
Publisher: Humana Press
Published: 2014-09-25
Total Pages: 488
ISBN-13: 9781493913978
DOWNLOAD EBOOKGalectins: Methods and Protocols is the first book solely dedicated to methodological approaches designed to study galectin function. The galectin family represents one of the most pleiotropic families, with individual members having been implicated in various aspects of nearly every biological process described, from RNA splicing to complex regulatory circuits that orchestrate adaptive immunity. Given the diverse roles of galectins in a variety of biological systems, studying these glycan binding proteins often requires the assimilation of diverse technical skills to fully appreciate their biological function. Their nearly ubiquitous expression and ability to bind highly modifiable carbohydrate ligands, in addition to a variety of other regulatory proteins, allows these glycan binding proteins (GBPs) to possess the capacity to regulate a wide variety of biological processes. Individual chapters are dedicated to examining salient features of galectin functions. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Galectins: Methods and Protocols seeks to serve both professionals and novices with a useful framework when examining galectin function for many years to come.
Author: Shie-Liang Hsieh
Publisher: Springer Nature
Published: 2020-03-09
Total Pages: 240
ISBN-13: 9811515808
DOWNLOAD EBOOKThis book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous ‘pathogen-associated molecular patterns’ or ‘damage-associated molecular patterns’. As such, microbes’ interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.
Author: Noel R. Rose
Publisher: John Wiley & Sons
Published: 2010-02-08
Total Pages: 297
ISBN-13: 1573317799
DOWNLOAD EBOOKThis volume in The Year in Immunology series focuses on reviews covering novel approaches to our understanding of immunoregulatory mechanisms. A wide-range of topics is covered within this volume, including: Lineage determination of T cells Roles of various receptors in B-cell activation Activation of plasmactyoid dendritic cells Micro-RNAs (miRNAs) in inflammation and immunity Autoimmune disorders NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Author: Shoib Sarwar Siddiqui
Publisher: Frontiers Media SA
Published: 2024-01-17
Total Pages: 154
ISBN-13: 2832542980
DOWNLOAD EBOOKGlycans are complex, multi-unit carbohydrate structures that cover the surfaces of cells and guide cellular interactions. Glycobiology studies the synthesis, structure, function, regulation, and evolution of glycans and glycan-binding molecules. Glycans are synthesized and added as modifications to proteins, lipids, and RNA. Though they are often associated with functions outside of cells (glycoproteins and glycolipids are most often extracellular or secreted), glycans are also active within cells. Glycans are known to have diverse physiological roles ranging from cell adhesion (maintaining tissue structure and integrity) to molecular recognition (marking position during development, or self-identity in immunity and reproduction). Glycans also regulate cellular activity and physiological state. The families of proteins that bind glycans are called lectins. Glycans and lectins are vital in many diseases such as cancer, neurodegeneration, inflammation, allergies, asthma, and autoimmune disorders.
Author: Hans-Joachim Gabius
Publisher: John Wiley & Sons
Published: 2008-09-26
Total Pages: 663
ISBN-13: 3527614729
DOWNLOAD EBOOKA comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes.
