G-Protein-Coupled Receptor Dimers
G-Protein-Coupled Receptor Dimers

Author: Katharine Herrick-Davis

Publisher: Humana Press

Published: 2017-09-12

Total Pages: 501

ISBN-13: 9783319601724

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G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

Protein Dimerization and Oligomerization in Biology
Protein Dimerization and Oligomerization in Biology

Author: Jacqueline M. Matthews

Publisher: Springer Science & Business Media

Published: 2012-09-04

Total Pages: 184

ISBN-13: 1461432294

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This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

Principles of Endocrinology and Hormone Action
Principles of Endocrinology and Hormone Action

Author: Antonino Belfiore

Publisher: Springer

Published: 2018-02-08

Total Pages: 0

ISBN-13: 9783319446745

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This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

G-Protein-Coupled Receptor Dimers
G-Protein-Coupled Receptor Dimers

Author: Katharine Herrick-Davis

Publisher: Springer

Published: 2017-08-31

Total Pages: 502

ISBN-13: 3319601741

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G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

Author: Denis J. Dupré

Publisher: Springer Science & Business Media

Published: 2012-11-19

Total Pages: 298

ISBN-13: 9400747659

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Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

The G-Protein Linked Receptor Facts Book
The G-Protein Linked Receptor Facts Book

Author: Steve P. Watson

Publisher: Academic Press

Published: 1994-02-28

Total Pages: 452

ISBN-13:

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Catalogues major facts about receptors, G-proteins and effector molecules. Each entry has a common format, using a minimum amount of text, and contains information on the sequence, gene structure, distribution, agonists/antagonists and physiochemical properties of these proteins.

Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine

Author: Robert C. Bast, Jr.

Publisher: John Wiley & Sons

Published: 2017-03-10

Total Pages: 2004

ISBN-13: 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cannabinoids and the Brain
Cannabinoids and the Brain

Author: Attila Köfalvi

Publisher: Springer Science & Business Media

Published: 2007-12-22

Total Pages: 587

ISBN-13: 0387743499

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Endocannabinoids have tremendous therapeutic potential. This book introduces readers to our current understanding of the neurobiology of endocannabinoids and related systems, detailing their pathophysiological role and therapeutic potential. Authors, experienced clinical investigators, present and analyze results of recent clinical trials as well as the development of new therapeutic strategies and medicines.

GPCR Molecular Pharmacology and Drug Targeting
GPCR Molecular Pharmacology and Drug Targeting

Author: Annette Gilchrist

Publisher: John Wiley & Sons

Published: 2010-12-10

Total Pages: 675

ISBN-13: 1118035178

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G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.