This book contains a series of review chapters from the world's leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.
This book contains a series of review chapters from the world''s leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.
Emerging Topics in Physical Virology is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, their assembly and disassembly, the organization of the viral genome, infection, evolution, as well as applications of viruses in Biomedical Nanotechnology. It is an essential primer for scientists working in all aspects of virology, including the increasing use of viruses and virus-like particles in bio- and nano-technology. Its review style makes it moreover suitable for non-experts as an introduction into this exciting research area.
1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clinical studies in gene therapy / Caroline Le Guiner [und weitere] -- 11. Gene therapy for central nervous system disorders / Deborah Young and Patricia A. Lawlor -- 12. Gene therapy of hemoglobinopathies / Angela E. Rivers and Arun Srivastava -- 13. Gene therapy for primary immunodeficiencies / Aisha Sauer, Barbara Cassani and Alessandro Aiuti -- 14. Gene therapy for hemophilia / David Markusic, Babak Moghimi and Roland Herzog -- 15. Gene therapy for obesity and diabetes / Sergei Zolotukhin and Clive H. Wasserfall -- 16. Gene therapy for Duchenne muscular dystrophy / Takashi Okada and Shin'ichi Takeda -- 17. Cancer gene therapy / Kirsten A.K. Weigel-Van Aken -- 18. Gene therapy for autoimmune disorders / Daniel F. Gaddy, Melanie A. Ruffner and Paul D. Robbins -- 19. Gene therapy for inherited metabolic storage diseases / Cathryn Mah -- 20. Retinal diseases / Shannon E. Boye, Sanford L. Boye and William W. Hauswirth -- 21. A brief guide to gene therapy treatments for pulmonary diseases / Ashley T. Martino, Christian Mueller and Terence R. Flotte -- 22. Cardiovascular disease / Darin J. Falk, Cathryn S. Mah and Barry J. Byrne
Ch. 1. Human rhinovirus cell entry and uncoating / Renate Fuchs and Dieter Blaas -- ch. 2. Role of lipid microdomains in influenza virus multiplication / Makoto Takeda -- ch. 3. Functions of integrin alpha2beta1, a collagen receptor, in the internalization of echovirus 1 / Varpu Marjomäki [und weitere] -- ch. 4. Entry mechanism of murine and SARS coronaviruses - similarity and dissimilarity / Fumihiro Taguchi -- ch. 5. Hepatitis viruses, signaling events, and modulation of the innate host response / Syed Mohammad Moin, Anindita Kar-Roy and Shahid Jameel -- ch. 6. Virus-cell interaction of HCV / Hideki Tani [und weitere] -- ch. 7. RNA replication of hepatitis C virus / Hideki Aizaki and Tetsuro Suzuki -- ch. 8. Structure and dynamics in viral RNA packaging / Thorsten Dieckmann and Marta Zumwalt -- ch. 9. Rational design of viral protein structures with predetermined immunological properties / James Lara and Yury Khudyakov -- ch. 10. Bioinformatics resources for the study of viruses at the Virginia Bioinformatics Institute / Anjan Purkayastha [und weitere] -- ch. 11. Virus architecture probed by atomic force microscopy / A.J. Malkin [und weitere] -- ch. 12. Filovirus assembly and budding / Takeshi Noda and Yoshihiro Kawaoka -- ch. 13. Challenges in designing HIV Env immunogens for developing a vaccine / Indresh K. Srivastava and R. Holland Cheng -- ch. 14. Insights into the Caliciviridae family / Grant Hansman -- ch. 15. Mathematical approaches for stoichiometric quantification in studies of viral assembly and DNA packaging / Peixuan Guo, Jeremy Hall and Tae Jin Lee -- ch. 16. Virus-like particles of fish nodavirus / Chan-Shing Lin -- ch. 17. The assembly of the double-layered capsids of phytoreoviruses / Toshihiro Omura [und weitere] -- ch. 18. Structure and assembly of human herpesviruses: new insights from cryo-electron microscopy and tomography / Z. Hong Zhou and Pierrette Lo -- ch. 19. Human papillomavirus type 16 capsid proteins: immunogenicity and possible use as prophylactic vaccine antigens / Tadahito Kanda, Kei Kawana and Hiroyuki Yoshikawa -- ch. 20. Chimeric recombinant Hepatitis E virus-like particles presenting foreign epitopes as a novel vector of vaccine by oral administration / Yasuhiro Yasutomi -- ch. 21. Nucleocapsid protein of hantaviruses (Bunyaviridae): structure and functions / Alexander Plyusnin [und weitere] -- ch. 22. Astrovirus replication: an overview / Susana Guix, Albert Bosch and Rosa M. Pintó -- ch. 23. DNA vaccines against viruses / Britta Wahren and Margaret Liu -- ch. 24. Life cycles of polyomaviridae - DNA tumor virus / Masaaki Kawano, Hiroshi Handa and R. Holland Cheng
Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
The story of the rise and fall of smallpox, one of the most savage killers in the history of mankind, and the only disease ever to be successfully exterminated (30 years ago next year) by a public health campaign.
Horace G. Danner’s A Thesaurus of English Word Roots is a compendium of the most-used word roots of the English language. As Timothy B. Noone notes in his foreword: “Dr. Danner’s book allows you not only to build up your passive English vocabulary, resulting in word recognition knowledge, but also gives you the rudiments for developing your active English vocabulary, making it possible to infer the meaning of words with which you are not yet acquainted. Your knowledge can now expand and will do so exponentially as your awareness of the roots in English words and your corresponding ability to decode unfamiliar words grows apace. This is the beginning of a fine mental linguistic library: so enjoy!” In A Thesaurus of English Word Roots, all word roots are listed alphabetically, along with the Greek or Latin words from which they derive, together with the roots’ original meanings. If the current meaning of an individual root differs from the original meaning, that is listed in a separate column. In the examples column, the words which contain the root are then listed, starting with their prefixes, for example, dysacousia, hyperacousia. These root-starting terms then are followed by terms where the root falls behind the word, e.g., acouesthesia and acoumeter. These words are followed by words where the root falls in the middle or the end, as in such terms as bradyacusia and odynacusis.. In this manner, A Thesaurus of English Word Roots places the word in as many word families as there are elements in the word. This work will interest linguists and philologists and anyone interested in the etymological aspects of English language.
