From Ecology to Cancer Biology and Back Again
Author: Frederick R. Adler
Publisher: Frontiers Media SA
Published: 2022-03-08
Total Pages: 259
ISBN-13: 2889746151
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Cancer through the Lens of Evolution and Ecology
Author: Jason A. Somarelli
Publisher: CRC Press
Published: 2024-05-29
Total Pages: 306
ISBN-13: 1040027687
DOWNLOAD EBOOKCancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.
The Cheating Cell
Author: Athena Aktipis
Publisher: Princeton University Press
Published: 2020-03-24
Total Pages: 256
ISBN-13: 0691163847
DOWNLOAD EBOOKA fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
Ecology and Evolution of Cancer
Author: Beata Ujvari
Publisher: Academic Press
Published: 2017-02-08
Total Pages: 292
ISBN-13: 0128043806
DOWNLOAD EBOOKEcology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies
The Emperor of All Maladies
Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
Published: 2011-08-09
Total Pages: 624
ISBN-13: 1439170916
DOWNLOAD EBOOKWinner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Why Birds Matter
Author: Çagan H. Sekercioglu
Publisher: University of Chicago Press
Published: 2016-08-24
Total Pages: 398
ISBN-13: 022638277X
DOWNLOAD EBOOKFor over one hundred years, ornithologists and amateur birders have jointly campaigned for the conservation of bird species, documenting not only birds’ beauty and extraordinary diversity, but also their importance to ecosystems worldwide. But while these avian enthusiasts have noted that birds eat fruit, carrion, and pests; spread seed and fertilizer; and pollinate plants, among other services, they have rarely asked what birds are worth in economic terms. In Why Birds Matter, an international collection of ornithologists, botanists, ecologists, conservation biologists, and environmental economists seeks to quantify avian ecosystem services—the myriad benefits that birds provide to humans. The first book to approach ecosystem services from an ornithological perspective, Why Birds Matter asks what economic value we can ascribe to those services, if any, and how this value should inform conservation. Chapters explore the role of birds in such important ecological dynamics as scavenging, nutrient cycling, food chains, and plant-animal interactions—all seen through the lens of human well-being—to show that quantifying avian ecosystem services is crucial when formulating contemporary conservation strategies. Both elucidating challenges and providing examples of specific ecosystem valuations and guidance for calculation, the contributors propose that in order to advance avian conservation, we need to appeal not only to hearts and minds, but also to wallets.
Frontiers in Cancer Research
Author: Carlo C. Maley
Publisher: Springer
Published: 2018-07-20
Total Pages: 258
ISBN-13: 9781493982073
DOWNLOAD EBOOKThis is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.
The Message of Ecology
Author: Charles J. Krebs
Publisher: Indo American Books
Published: 2007
Total Pages: 210
ISBN-13: 9788189617431
DOWNLOAD EBOOKEcology Is A Fascinating Subject. This Is A Book To Introduce You To It And The Problems Ecologists Try To Analyze. Above All It Is An Attempt To Present The Subject In A Direct, Simple Form Without Including The Detail That Is Necessary In A More Conventional Textbook And Without Burdening The Subject With Abstruse Definitions Or Voluminous Statistics. So Do Not View This Book As A Text But As Supplemental Reading Designed For An Introductory Biology Course Or For A First Course In Ecology.
The Ecological Theater and the Evolutionary Play
Author: George Evelyn Hutchinson
Publisher: New Haven : Yale University Press
Published: 1965
Total Pages: 139
ISBN-13: 9780300005868
DOWNLOAD EBOOKIn this delightful collection of essays, the author of The Enchanted Voyage and The Itinerant Ivory Tower turns his attention to the influence of environment on evolution. His discussion of the nature of the terrestrial environment we know leads to an account of possible ecological conditions on other bodies in the universe. Mr. Hutchinson also deals specifically with some influences on man's evolution, emphasizing the extremely recondite nature of these forces. One of the other pieces looks at the relationship of natural beauty to works of art, particularly in the context of comparisons between natural history museums and art galleries. The final essay, "The Cream in the Gooseberry Fool," is an entertaining account of an English country clergyman's work with the European magpie moth, which resulted in one of the most significant early discoveries in genetics. The treatment throughout requires no technical learning, though the most important and modern theoretical results are cited in the footnotes.
Explaining Cancer
Author: Anya Plutynski
Publisher: Oxford University Press
Published: 2018-07-18
Total Pages: 281
ISBN-13: 0199967466
DOWNLOAD EBOOKIn Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.
