A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Exercise, a healthy diet, stress management, sound sleep: Most practitioners would agree that living well can mitigate the impact of mental disorders. Yet many are unprepared to address lifestyle factors in their care of patients. Lifestyle Psychiatry seeks to instill confidence by collating and analyzing the impressive emerging body of evidence that supports the efficacy of healthy lifestyle practices -- both as the primary intervention and in conjunction with traditional treatments such as psychopharmacology or psychotherapy -- in preventing and managing psychiatric disorders. This volume examines the impact of lifestyle interventions -- from exercise, yoga, and tai chi to mindfulness and meditation, diet and nutrition, and sleep management -- on psychiatric disorders, including depression, anxiety, posttraumatic stress disorder, schizophrenia, and addiction. Readers can readily find data to support the use of specific lifestyle interventions for a patient presenting with a specific disorder. Detailed descriptions of the mechanisms of each lifestyle intervention also prepare practitioners to educate their patients on the specific neurobiological and psychological effects of these interventions to support their recovery. With chapters that focus on developing a robust therapeutic alliance and inspiring patients to assume responsibility for their own well-being, this guide provides a framework for lasting, sustainable lifestyle changes. Additionally, the book discusses the impact of the provider's lifestyle on clinical behavior and the implications of lifestyle medicine and psychiatry for health care systems and population health, offering a broader examination of the important role this new field can play in leading a sophisticated, holistic approach to optimizing wellness.
Traumatic Dissociation: Neurobiology and Treatment offers an advanced introduction to this symptom, process, and pattern of personality organization seen in several trauma-related disorders, including acute stress disorder, posttraumatic stress disorder (PTSD), and the dissociative disorders. Our understanding of traumatic dissociation has recently been advanced by neuroimaging technology, empirically-based investigation, and an acknowledgment of its importance in psychopathology. The authors of this volume tie these findings together, tracking the condition from its earliest historical conceptualization to its most recent neurobiological understanding to provide even greater insight into traumatic dissociation and its treatment. Bringing together for the first time theoretical, cognitive, and neurobiological perspectives on traumatic dissociation, this volume is designed to provide both empirical and therapeutic insights by drawing on the work of many of the main contributors to the field. Opening chapters examine historical, conceptual, and theoretical issues and how other fields, such as cognitive psychology, have been applied to the study of traumatic dissociation. The following section focuses specifically on how neurobiological investigations have deepened our understanding of dissociation and concluding chapters explore issues pertinent to the assessment and treatment of traumatic dissociation. The interacting effects of traumatic experience, developmental history, neurobiological function, and specific vulnerabilities to dissociative processes that underlie the occurrence of traumatic dissociation are among some of the key issues covered. The book's significant contributions include A review of cognitive experimental findings on attention and memory functioning in dissociative identity disorder An appreciation of how the literature on hypnosis provides a greater understanding of perceptual processing and traumatic stress Ascertaining symptoms of dissociation in a military setting and in other situations of extreme stress An outline of key issues for planning assessment of traumatic dissociation, including a critique of its primary empirically supported standardized measures An examination of the association between child abuse or neglect and the development of eating disorders, suggesting ways to therapeutically deal with negative body experience to reduce events that trigger dissociation A description of neuroendocrine alterations associated with stress, pointing toward a better understanding of the developmental effects of deprivation and trauma on PTSD and dissociation A review of the relation of attachment and dissociation A discussion of new research findings in the neuroimaging of dissociation and a link between cerebellar functioning and specific peritraumatic experiences Useful as a clinical reference or as ancillary textbook, Traumatic Dissociation reorganizes phenomenological observations that have been overlooked, misunderstood, or neglected in traditional training. The research and clinical experience described here will provide the basis for further clinical and theoretical formulations of traumatic dissociation and will advance empirical examination and treatment of the phenomenon.
Here is the first volume of a new series that explores diversity, culture, and ethnicity and their impact on neurological function. This volume features research-based evidence on the impact of Hispanic culture on brain-behavior relationships. Articles explore factors such as acculturation, assimilation, cultural identity, and migration patterns. Clinical issues, such as competence and minimal standards and novel approaches for appropriate assessments of Hispanic populations, are examined. You’ll discover important new findings and gain fascinating perspectives from disciplines in both the life and social sciences.
The inspirational success story of the first 100 years of Hutchinson Builders. What started out as a one-man band in 1912, when an English immigrant builder arrived with his family to start a new life in Australia, has grown into the country's largest privately owned construction company. The Hutchies' story straddles a century that witnessed two world wars, the great depression and tumultuous cycles of financial crises against the back drop of the rough and tumble world of construction. As well as tracking the survival and eventual growth of Hutchies into the dynamic and well respected company of today, the book outlines its evolution through successive generations of Jack Hutchinsons at the helm with a fifth generation poised to take on that role. That story is told by way of a historical account as well as captured through the republication and inclusion of every back issue of "Hutchies' Truth", the company's colourful, tabloid-style newsletter covering those years.
In the second half of the 1990s, Stuart Eizenstat was perhaps the most controversial U.S. foreign policy official in Europe. His mission had nothing to do with Russia, the Middle East, Yugoslavia, or any of the other hotspots of the day. Rather, Eizenstat's mission was to provide justice—albeit belated and imperfect justice—for the victims of World War II. Imperfect Justice is Eizenstat's account of how the Holocaust became a political and diplomatic battleground fifty years after the war's end, as the issues of dormant bank accounts, slave labor, confiscated property, looted art, and unpaid insurance policies convulsed Europe and America. He recounts the often heated negotiations with the Swiss, the Germans, the French, the Austrians, and various Jewish organizations, showing how these moral issues, shunted aside for so long, exposed wounds that had never healed and conflicts that had never been properly resolved. Though we will all continue to reckon with the crimes of World War II for a long time to come, Eizenstat's account shows that it is still possible to take positive steps in the service of justice.
This book provides detailed analyses of systems that have been established to provide reparations to victims of genocide, crimes against humanity and war crimes, and the way in which these systems have worked and are working in practice. Many of these systems are described and assessed for the first time in an academic publication. The publication draws upon a groundbreaking Conference organised by the Clemens Nathan Research Centre (CNRC) and REDRESS at the Peace Palace in The Hague, with the support of the Dutch Carnegie Foundation. Both CNRC and REDRESS had become very concerned about the extreme difficulty encountered by most victims of serious international crimes in attempting to access effective and enforceable remedies and reparation for harm suffered. In discussions between the Conference organisers and Judges and officials of the International Criminal Court, it became ever more apparent that there was a great need for frank and open exchanges on the question of effective reparation, between the representatives of victims, of NGOs and IGOs, and other experts. It was clear to all that the many current initiatives of governments and regional and international institutions to afford reparations to victims of genocide, crimes against humanity and war crimes could benefit greatly by taking into full account the wide and varied practice that had been built up over several decades. In particular, the Hague Conference sought to consider in detail the long experience of the Conference on Jewish Material Claims against Germany (the Claims Conference) in respect of Holocaust restitution programmes, as well as the practice of truth commissions, arbitral proceedings and a variety of national processes to identify common trends, best practices and lessons. This book thus explores the actions of governments, as well as of national and international courts and commissions in applying, processing, implementing and enforcing a variety of reparations schemes and awards. Crucially, it considers the entire complex of issues from the perspective of the beneficiaries - survivors and their communities - and from the perspective of the policy-makers and implementers tasked with resolving technical and procedural challenges in bringing to fruition adequate, effective and meaningful reparations in the context of mass victimisation.
