Forensic Practitioner's Guide to the Interpretation of Complex DNA Profiles
Forensic Practitioner's Guide to the Interpretation of Complex DNA Profiles

Author: Peter Gill

Publisher: Academic Press

Published: 2020-06-10

Total Pages: 532

ISBN-13: 0128205687

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Over the past twenty years, there's been a gradual shift in the way forensic scientists approach the evaluation of DNA profiling evidence that is taken to court. Many laboratories are now adopting 'probabilistic genotyping' to interpret complex DNA mixtures. However, current practice is very diverse, where a whole range of technologies are used to interpret DNA profiles and the software approaches advocated are commonly used throughout the world. Forensic Practitioner's Guide to the Interpretation of Complex DNA Profiles places the main concepts of DNA profiling into context and fills a niche that is unoccupied in current literature. The book begins with an introduction to basic forensic genetics, covering a brief historical description of the development and harmonization of STR markers and national DNA databases. The laws of statistics are described, along with the likelihood ratio based on Hardy-Weinberg equilibrium and alternative models considering sub-structuring and relatedness. The historical development of low template mixture analysis, theory and practice, is also described, so the reader has a full understanding of rationale and progression. Evaluation of evidence and statement writing is described in detail, along with common pitfalls and their avoidance. The authors have been at the forefront of the revolution, having made substantial contributions to theory and practice over the past two decades. All methods described are open-source and freely available, supported by sets of test-data and links to web-sites with further information. This book is written primarily for the biologist with little or no statistical training. However, sufficient information will also be provided for the experienced statistician. Consequently, the book appeals to a diverse audience - Covers short tandem repeat (STR) analysis, including database searching and massive parallel sequencing (both STRs and SNPs) - Encourages dissemination and understanding of probabilistic genotyping by including practical examples of varying complexity - Written by authors intimately involved with software development, training at international workshops and reporting cases worldwide using the methods described in this book

Techniques of Crime Scene Investigation
Techniques of Crime Scene Investigation

Author: Barry A. J. Fisher

Publisher: CRC Press

Published: 2022-07-05

Total Pages: 369

ISBN-13: 1498758142

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"Techniques of Crime Scene Investigation is a staple for any forensic science library and is routinely referenced by professional organizations as a study guide for certifications. It is professionally written and provides updated theoretical and practical applications using real casework. This text is a must-have for any CSI Unit or course teaching Crime Scene Investigation." – Kevin Parmelee, PhD, Detective (ret.), Somerset County, NJ Prosecutor’s Office Since the first English-language edition of Techniques of Crime Scene Investigation was published in 1964, the book has continued to be a seminal work in the field of forensic science, serving as a foundational textbook and reference title for professionals. This Ninth Edition includes several new chapters and has been fully updated and organized to present the effective use of science and technology in support of justice. New coverage to this edition addresses the debunking of a few forensic science disciplines, long thought to have been based on sound science. The book provides students, crime scene investigators, forensic scientists, and attorneys the proper ways to examine crime scenes and collect a wide variety of physical evidence that may be encountered. While it is not possible to cover every imaginable situation, this book is a comprehensive guide that details and promotes best practices and recommendations. In today’s challenging environment, it is essential that law enforcement personnel thoroughly understand and meticulously comply with the forensic evidence procedures that apply to their function in the investigation process. Criminal investigations remain as complex as ever and require professionals from many disciplines to work cooperatively toward the fair and impartial delivery of justice. Practitioners and students alike need to be aware of the increased scrutiny that they will face in the judicial system. Judges are taking a more involved role than ever before as far as the evidence and testimony that they allow into their courtrooms. No longer will substandard forensic science or crime scene investigation be acceptable. Key features: Newly reorganized contents—including 4 brand new chapters—reflects a more logical flow of crime scene processes and procedures Provides an overview of the crime scene investigation process and procedures, from the first officer on the scene through the adjudication of the case Includes several new cases, photos, and updates in technological advances in both digital evidence and DNA in particular Science and technology applied to CSI solves crimes and saves lives. Investigators, prosecutors, and defense attorneys must be able to use forensic tools and resources to their fullest potential and Techniques of Crime Scene Investigation serves as an invaluable resource to further this cause.

Forensic DNA Profiling
Forensic DNA Profiling

Author: Jo-Anne Bright

Publisher: CRC Press

Published: 2019-12-09

Total Pages: 192

ISBN-13: 0429671423

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DNA testing and its forensic analysis are recognized as the “gold standard” in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately, many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such, the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods, the polymerase chain reaction (PCR), capillary electrophoresis (CE), likelihood ratios (LRs) and their interpretation, and population genetic models—including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework, ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES: • The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results • Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel • New methods, heretofore unpublished previously, provide a means to innovate deconvoluting a mixed DNA profile, assign an LR, and appropriately report the weight of evidence • Includes a chapter on assigning LRs for close relatives (i.e., “It’s not me, it was my brother”), and discusses strategies for the validation of probabilistic genotyping software Forensic DNA Profiling fills the void for labs unfamiliar with LRs, and moving to probabilistic solutions, and for labs already familiar with LRs, but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians, students, and legal professionals seeking to understand and apply the techniques covered.

Forensic Science
Forensic Science

Author: Ian Shaw

Publisher: Royal Society of Chemistry

Published: 2024-10-23

Total Pages: 282

ISBN-13: 1837670412

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Forensic science is often important in criminal cases, so criminal justice professionals, including lawyers and forensic scene investigators, must have a basic understanding of what is often complex science. This book explains the science underpinning forensic techniques to give those who engage with forensic science professionally, but who are not primarily scientists, a level of understanding that will enable them to use forensic science data effectively. In addition, the book places the use of forensic data in the context of criminal cases to assess the reliability and usefulness of forensic data in court. Succinctly presented, this book covers all the facets of forensic science for students who are hoping to become police officers, lawyers or other members of the criminal justice system. As forensic investigations have advanced, e.g. in DNA profiling, computer modelling and behavioural sciences, so has the need for an increase in the level of scientific knowledge. The author understands the challenges this brings and has written the book to explain complex information in an accessible and undemanding style. Using international case studies, this book will bring forensic science to life and include aspects of the author's personal journey.

Advanced Topics in Forensic DNA Typing: Interpretation
Advanced Topics in Forensic DNA Typing: Interpretation

Author: John M. Butler

Publisher: Academic Press

Published: 2014-07-28

Total Pages: 609

ISBN-13: 012405854X

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Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. - Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence - Worked mixture examples illustrate the impact of different statistical approaches for reporting results - Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011

Interpreting Complex Forensic DNA Evidence
Interpreting Complex Forensic DNA Evidence

Author: Jane Moira Taupin

Publisher: CRC Press

Published: 2019-11-14

Total Pages: 162

ISBN-13: 1351023772

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Interpreting Complex Forensic DNA Evidence is a handy guide to recent advances—and emerging issues—in interpreting complex DNA evidence and profiles for use in criminal investigations. In certain cases, DNA cannot be connected to a specific biological material such as blood, semen or saliva. How or when the DNA was deposited may be an issue. The possibility of generating DNA profiles from touched objects, where there may not be a visible deposit, has expanded the scope and number of exhibits submitted for DNA analysis. With such advances, and increasing improvements in technological capabilities in testing samples, this means it is possible to detect ever smaller amounts of DNA. There are also many efforts underway to seek was to interpret DNA profiles that are sub-optimal—either relative to the amount required by the testing kit and, potentially, the quality of the obtained sample. Laboratories often use enhancements in order to obtain a readable DNA profile. The broad-reaching implications of improving DNA sensitivity have led to this next, emerging generation of more complex profiles. Examples partial profiles that do not faithfully reflect the proposed donor, or mixtures of partial DNA from multiple people. A complexity threshold has been proposed to limit interpretation of poor-quality data. Research is now addressing the interpretation of transfer of trace amounts of DNA. Complex issues are arising in trial that need to be reconciled as such complexity has added challenges to the interpretation of evidence and its introduction or dismissal in certain cases in the courts. Key Features: Addresses DNA transfer, from person-to-person as well as to objects Outlines each stage required to produce a DNA profile from an exhibit—including collection, handling, storage, and analysis Discusses ethics, subjectivity, and bias—including cognitive dissonance—as they relate specifically to complex DNA evidence Highlights current techniques and the latest advances in DNA analysis, including advances in familial DNA searches Interpreting Complex Forensic DNA Evidence provides tools to assist the criminal investigator, forensic expert, and legal professional when posed with a DNA result in a forensic report or testimony. The result—and any associated statistic—may not reveal any ambiguity, complexity, or the assumptions involved in deriving it. Questions from resolved criminal cases are posed, and the relevant forensic literature, provided for the reader to assess a DNA result and any associated statistic. Case studies throughout illustrate concepts and emphasize the need for conclusions in the forensic report that are supported by the data.

Forensic Science Evidence and Expert Witness Testimony
Forensic Science Evidence and Expert Witness Testimony

Author: Paul Roberts

Publisher: Edward Elgar Publishing

Published: 2018-11-30

Total Pages: 454

ISBN-13: 1788111036

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Forensic science evidence plays a pivotal role in modern criminal proceedings. Yet such evidence poses intense practical and theoretical challenges. It can be unreliable or misleading and has been associated with miscarriages of justice. In this original and insightful book, a global team of prominent scholars and practitioners explore the contemporary challenges of forensic science evidence and expert witness testimony from a variety of theoretical, practical and jurisdictional perspectives. Chapters encompass the institutional organisation of forensic science, its procedural regulation, evaluation and reform, and brim with comparative insight.

An Introduction to Forensic Genetics
An Introduction to Forensic Genetics

Author: William Goodwin

Publisher: John Wiley & Sons

Published: 2007-11-27

Total Pages: 170

ISBN-13: 0470010258

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An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science. This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented. An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context Includes case studies to enhance student understanding Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future Accessible treatment of population biology and statistics associated with forensic evidence This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.

Using Forensic DNA Evidence at Trial
Using Forensic DNA Evidence at Trial

Author: Jane Moira Taupin

Publisher: CRC Press

Published: 2018-09-03

Total Pages: 238

ISBN-13: 1315360683

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Using Forensic DNA Evidence at Trial: A Case Study Approach covers the most common DNA analysis methods used in criminal trials today, including STR techniques, mitochondrial DNA, and Y-STRs. It presents some novel techniques—including familial testing and analyzing domestic animal hair—that have been recently introduced in unique cases, each of which is outlined in detail. It also illustrates special issues related to forensic DNA evidence by using court proceedings such as trials and appeals, commissions of inquiry, and government and laboratory reviews. With forensic DNA analysis becoming increasingly important at trial, the lively and sometimes bizarre cases presented in this book have been carefully chosen to highlight specific concepts, methods, and interpretations used in DNA analysis. Sections throughout examine the nature of expertise with a special focus on the role of subjectivity in the interpretation of forensic DNA evidence, emphasizing cognitive bias and extraneous context. Using both convictions and exonerations as examples, the book also discusses the strengths and limitations of DNA evidence and testing. The book is written in an accessible manner for the non-scientific reader, such that criminal lawyers, judges, and forensic experts will all understand the nature of analysis and application of DNA evidence in a variety of court cases. Extensive references—including notable trial proceedings, cross references of cases, and specific forensic statistics—round out the book and help to provide a complete understanding of forensic DNA analysis and its current usage in the courtroom.

Interpreting DNA Evidence
Interpreting DNA Evidence

Author: Ian Evett

Publisher: Sinauer Associates Incorporated

Published: 1998-01-01

Total Pages: 278

ISBN-13: 9780878931552

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Interpretation of DNA profile matches depends on the use of statistical weights. This text provides the background information in statistics and genetics for the reader to arrive at these weights.