Folded Selves
Folded Selves

Author: Michelle Burnham

Publisher: Dartmouth College Press

Published: 2014-06-14

Total Pages: 233

ISBN-13: 1611686849

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Folded Selves radically refigures traditional portraits of seventeenth-century New England literature and culture by situating colonial writing within the spatial, transnational, and economic contexts that characterized the early-modern "world system" theorized by Immanuel Wallerstein and others. Michelle Burnham rethinks American literary history and the politics of colonial dissent, and her book breaks new ground in making the economic relations of investment, credit, and trade central to this new framework for early American literary and cultural study. Transcontinental colonialism and mercantile capitalism underwrote not just the emerging world system but New World writing -- suggesting that early modern literary aesthetics and the early modern economy helped to sponsor each other. Burnham locates in New England's literature of dissent -- from Ma-re Mount to the Salem witchcraft trials -- a persistent use of economic language, as well as competing economies of style. The brilliance of Burnham's study is that it exposes the transoceanic material and commercial concerns of colonial America's literature and culture of dissent.

Folding and Self-assembly of Biological Macromolecules
Folding and Self-assembly of Biological Macromolecules

Author: Eric Westhof

Publisher: World Scientific

Published: 2004

Total Pages: 417

ISBN-13: 9812385002

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This proceedings volume explores the pathways and mechanisms by which constituent residues interact and fold to yield native biological macromolecules (catalytic RNA and functional proteins), how ribosomes and other macromolecular complexes self-assemble, and relevant energetics considerations. At the week-long interactive conference, some 20 leading researchers reported their most pertinent results, confronting each other and an audience of more than 150 specialists from a wide range of scientific disciplines, including structural and molecular biology, biophysics, computer science, mathematics, and theoretical physics. The fourteen papers - and audience interaction - are edited and illustrated versions of the transcribed oral presentations.

Protein Folding and Self-Avoiding Walks Polyhedral Studies and Solutions
Protein Folding and Self-Avoiding Walks Polyhedral Studies and Solutions

Author: Agnes Dittel

Publisher: Logos Verlag Berlin GmbH

Published: 2008

Total Pages: 362

ISBN-13: 3832520236

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The protein folding problem refers to the correlation of a protein's amino acid sequence and its native three-dimensional structure which is essential for functionality. It still constitutes one of the major challenges in computational biology. One commonly studied model for the protein folding problem is the HP lattice model in which proteins are considered in a fairly abstract representation. However, the HP model proteins exhibit significant parallels to proteins occurring in nature. The solution of the HP lattice mode as a combinatorial optimization problem has been proven to be NP-complete, and there have already been developed various different approaches for efficient algorithms. We study an integer programming formulation of the problem. Starting with an analysis of this model, where we concentrate on symmetry issues, we show how the model can be consolidated by exploiting symmetry properties of the underlying lattice. The main focus lies in the development of specific components of a branch-and-cut framework for the computation of solutions for the HP model by means of integer programming methods. In order to understand the structure of the model, we perform a series of polyhedral studies from which we derive two main classes of cutting planes. Furthermore, we exploit the knowledge of folding principles which are also valid for HP model proteins for the development of related branching strategies. For the solution of a special class of instances, we present an implementation of a genetic algorithm for the generation of primal feasible start solutions. Finally, we document the performance of the methods developed for each of the four topics (model consolidation, primal method, branching strategy and cutting planes) within the branch-and-cut procedure. We present computational results for different types of lattices, where we both consider known benchmark instances from literature and random instances.

Folded Synthetic Peptides for Biomedical Applications
Folded Synthetic Peptides for Biomedical Applications

Author: Alessandro Contini

Publisher: Frontiers Media SA

Published: 2019-09-26

Total Pages: 145

ISBN-13: 2889630455

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Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.

On Folding
On Folding

Author: Michael Friedman

Publisher: transcript Verlag

Published: 2016-05-31

Total Pages: 243

ISBN-13: 3839434041

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It is only recently, with the increasing interest in origami and folding in natural sciences and the humanities, that the fold as a new conception in a whole range of disciplines has begun to be conceived in a broader way. Folding as a material and structural process offers a new methodology to think about the close relationship of matter, form and code. It henceforth crosses out old dichotomies, such as the organic and the inorganic or nature and technology, and blurs the boundaries between experimental, conceptual and historical approaches. This anthology aims to unfold this new interdisciplinary field and its disciplinary impact, ranging from materials science, biology, architecture, and mathematics to literature and philosophy.

Molecular Biology of Protein Folding, Part B
Molecular Biology of Protein Folding, Part B

Author: P. Michael Conn

Publisher: Academic Press

Published: 2009-01-09

Total Pages: 301

ISBN-13: 0080923399

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Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. Follow the new editor-in-chief, P. Michael Conn, as he introduces this second thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

The Man Who Folded Himself
The Man Who Folded Himself

Author: David Gerrold

Publisher: ReadHowYouWant.com

Published: 2011-02-02

Total Pages: 218

ISBN-13: 1459610970

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This classic work of science fiction is widely considered to be the ultimate time-travel novel. When Daniel Eakins inherits a time machine, he soon realizes that he has enormous power to shape the course of history. He can foil terrorists, prevent assassinations, or just make some fast money at the racetrack. And if he doesn't like the results of the change, he can simply go back in time and talk himself out of making it! But Dan soon finds that there are limits to his powers and forces beyond his control.