The model system of eyeblink classical conditioning in humans has enormous potential for the understanding and application of fundamental principles of learning. This collection makes classical conditioning accessible to teachers and researchers in a number of ways. The first aim is to present the latest developments in theory building. Second, as background for the current directions, Eyeblink Classical Conditioning, Volume I presents an overview of a large body of previously published research on eyeblink classical conditioning. Last, the authors describe eyeblink classical conditioning techniques. Each chapter includes a highlighted methods section so that interested readers can replicate techniques for teaching and research.
This book explores hands-on issues of how to implement classical conditioning experiments, describing many of the techniques and equipment used to discover the locus for a simple memory in the brain. It details circuit diagrams for instrumentation and software for control and analysis.
Classical conditioning of the nictitating membrane (NM) eyeblink response in rabbits is a useful model system for the study of the neurobiology of learning and memory. This paradigm that is so well described on a biological level has also been applied to studies of normal development over the life span and to instances of abnormal developmental phenomena. Eyeblink conditioning has been studied from molecular and neural network perspectives, and the paradigm is of demonstrated utility in elucidating mechanisms in physiology and pharmacology. This model system provides a behavioral paradigm in animals that has a close analog in human behavior. Perspectives of recent developments in human eyeblink classical conditioning research are presented in the companion volume to this book, Eyeblink Classical Conditioning: Applications in Humans.
‘Behavioral Neuroscience of Learning and Memory’ brings together the opinions and expertise of some of the world’s foremost neuroscientists in the field of learning and memory research. The volume provides a broad coverage of contemporary research and thinking in this field, focusing both on well established topics such as the medial temporal lobe memory system, as well as emerging areas of research such as the role of memory in decision making and the mechanisms of perceptual learning. Key intersecting themes include the molecular and cellular mechanisms of memory formation, the multiplicity of memory systems in the brain, and the way in which technological innovation is driving discovery. Unusually for a volume of this kind, this volume brings together research from both humans and animals—often relatively separate areas of discourse—to give a more comprehensive and integrated view of the field. The book will be of interest to both established researchers who wish to broaden their knowledge of topics outside of their specific areas of expertise, and for students who need a resource to help them make sense of the vast scientific literature on this subject.
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
This volume contains a collection of papers written by former students, postdoctoral fellows, and colleagues of Richard Thompson and represent written versions of papers presented at the Festschrift symposium. The Festschrift provided an excellent opportunity for the participants to recount their memories and experiences of working with one of the leading figures in behavioral neuroscience, and to place their current research in the context of earlier research conducted in the Thompson laboratory. As a Festschrift volume, the various chapters contain numerous and sometimes very personal references to Richard Thompson's influence on the careers of the authors, as well as summaries of past and present work being conducted in the authors' laboratories. Part I includes studies of spinal cord plasticity and the involvement of the hippocampus and related structure in classical eyeblink conditioning. Part II explores the critical role of the cerebellum and associated areas in classical eyeblink conditioning. Part III focuses on a continued exploration of the involvement of the cerebellum in classical eyeblink conditioning using standard procedures as well as innovative molecular biology and genetic techniques. It also includes studies aimed at delineating modulatory influences on learning such as stress and hormonal factors. The incredible influence that Richard Thompson has had on the fields of experimental psychology and neuroscience should be evident on reading the contributions made by the various authors to this volume. The research conducted in Thompson's laboratory over the years has been cutting-edge, comprehensive, and influential. Therefore, this volume is dedicated to Richard F. Thompson a productive, innovative scientist and outstanding mentor.
Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. - Organized by function, making it easy to find and understand the material - Addresses impairments both associated with diseases and not associated with diseases - Written by leading researchers in the field - Most comprehensive source of information on the neurobiology of aging
This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader's understanding. - More than 25% new content, particularly expanding the scope to include new findings in translational research. - Unique in its depth of coverage of molecular and cellular mechanisms - Extensive cross-referencing to Comprehensive Learning and Memory - Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
The goal of this study was to demonstrate eyeblink classical conditioning (EBCC) to an olfactory stimulus and apply this technique to patients with Alzheimer's disease (AD) and those at-risk for AD by virtue of genetic status. A total of 95 people participated in this research: 15 people diagnosed with AD and 80 normal control participants, 28 of whom were carriers of the [special characters omitted]4 allele of apolipoprotein-E. Study 1: The goal of the first study was to determine whether humans could acquire a conditioned response (CR) to an olfactory conditioned stimulus (CS). Ten control subjects were tested in an EBCC delay paradigm with an olfactory CS. Results indicated that participants were able to learn and demonstrate a CR to an odorant stimulus. Study 2: The second study was designed to examine the role of inter-stimulus interval (ISI) on rate of CR acquisition with an olfactory CS. Twenty-four older adults were tested with either a long or a short ISI. Results indicate that acquisition of the CR by older adults is enhanced with a longer ISI. Study 3: Studies have shown that EBCC to auditory tones is a good discriminator of diseased from normal populations. There are not many studies in the field, making replication of those findings important. Given the documented olfactory dysfunction in AD, it was hypothesized that EBCC with an olfactory CS would provide a better discriminator between demented and non-demented older adults than an auditory CS. Performance of 15 patients with AD was compared to that of 30 control participants. Results indicate slowed olfactory CR acquisition in patients with AD. Study 4: This study was designed to examine performance of a group of people at risk for AD by virtue of genetic susceptibility (apoE, [special characters omitted] 4 positive). Performance of 30 healthy control participants (the same participants included in Study 3) was compared to performance of 28 [special characters omitted] 4 positive participants. No differences were found between the groups for overall CR acquisition to an auditory or an olfactory CS; however, the at risk group did evidence a slower rate of acquisition to the olfactory CS.
