Exploring Mathematical Modeling in Biology Through Case Studies and Experimental Activities
Exploring Mathematical Modeling in Biology Through Case Studies and Experimental Activities

Author: Rebecca Sanft

Publisher: Academic Press

Published: 2020-03-30

Total Pages: 262

ISBN-13: 0128195967

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Exploring Mathematical Modeling in Biology through Case Studies and Experimental Activities provides supporting materials for courses taken by students majoring in mathematics, computer science or in the life sciences. The book's cases and lab exercises focus on hypothesis testing and model development in the context of real data. The supporting mathematical, coding and biological background permit readers to explore a problem, understand assumptions, and the meaning of their results. The experiential components provide hands-on learning both in the lab and on the computer. As a beginning text in modeling, readers will learn to value the approach and apply competencies in other settings. Included case studies focus on building a model to solve a particular biological problem from concept and translation into a mathematical form, to validating the parameters, testing the quality of the model and finally interpreting the outcome in biological terms. The book also shows how particular mathematical approaches are adapted to a variety of problems at multiple biological scales. Finally, the labs bring the biological problems and the practical issues of collecting data to actually test the model and/or adapting the mathematics to the data that can be collected. - Presents a single volume on mathematics and biological examples, with data and wet lab experiences suitable for non-experts - Contains three real-world biological case studies and one wet lab for application of the mathematical models - Includes R code templates throughout the text, which are also available through an online repository, along with the necessary data files to complete all projects and labs

Control Theory in Biomedical Engineering
Control Theory in Biomedical Engineering

Author: Olfa Boubaker

Publisher: Academic Press

Published: 2020-06-30

Total Pages: 398

ISBN-13: 0128226218

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Control Theory in Biomedical Engineering: Applications in Physiology and Medical Robotics highlights the importance of control theory and feedback control in our lives and explains how this theory is central to future medical developments. Control theory is fundamental for understanding feedback paths in physiological systems (endocrine system, immune system, neurological system) and a concept for building artificial organs. The book is suitable for graduate students and researchers in the control engineering and biomedical engineering fields, and medical students and practitioners seeking to enhance their understanding of physiological processes, medical robotics (legs, hands, knees), and controlling artificial devices (pacemakers, insulin injection devices).Control theory profoundly impacts the everyday lives of a large part of the human population including the disabled and the elderly who use assistive and rehabilitation robots for improving the quality of their lives and increasing their independence. - Gives an overview of state-of-the-art control theory in physiology, emphasizing the importance of this theory in the medical field through concrete examples, e.g., endocrine, immune, and neurological systems - Takes a comprehensive look at advances in medical robotics and rehabilitation devices and presents case studies focusing on their feedback control - Presents the significance of control theory in the pervasiveness of medical robots in surgery, exploration, diagnosis, therapy, and rehabilitation

Mathematical Modeling in Systems Biology
Mathematical Modeling in Systems Biology

Author: Brian P. Ingalls

Publisher: MIT Press

Published: 2022-06-07

Total Pages: 423

ISBN-13: 0262545829

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An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

Annual Report
Annual Report

Author: National Cancer Institute (U.S.). Division of Cancer Etiology

Publisher:

Published: 1989

Total Pages: 346

ISBN-13:

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An Introduction to Mathematical Modeling
An Introduction to Mathematical Modeling

Author: Edward A. Bender

Publisher: Courier Corporation

Published: 2012-05-23

Total Pages: 273

ISBN-13: 0486137120

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Employing a practical, "learn by doing" approach, this first-rate text fosters the development of the skills beyond the pure mathematics needed to set up and manipulate mathematical models. The author draws on a diversity of fields — including science, engineering, and operations research — to provide over 100 reality-based examples. Students learn from the examples by applying mathematical methods to formulate, analyze, and criticize models. Extensive documentation, consisting of over 150 references, supplements the models, encouraging further research on models of particular interest. The lively and accessible text requires only minimal scientific background. Designed for senior college or beginning graduate-level students, it assumes only elementary calculus and basic probability theory for the first part, and ordinary differential equations and continuous probability for the second section. All problems require students to study and create models, encouraging their active participation rather than a mechanical approach. Beyond the classroom, this volume will prove interesting and rewarding to anyone concerned with the development of mathematical models or the application of modeling to problem solving in a wide array of applications.

Collective Animal Behavior
Collective Animal Behavior

Author: David J. T. Sumpter

Publisher: Princeton University Press

Published: 2010-09-27

Total Pages: 313

ISBN-13: 1400837103

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How and why animals produce group behaviors Fish travel in schools, birds migrate in flocks, honeybees swarm, and ants build trails. How and why do these collective behaviors occur? Exploring how coordinated group patterns emerge from individual interactions, Collective Animal Behavior reveals why animals produce group behaviors and examines their evolution across a range of species. Providing a synthesis of mathematical modeling, theoretical biology, and experimental work, David Sumpter investigates how animals move and arrive together, how they transfer information, how they make decisions and synchronize their activities, and how they build collective structures. Sumpter constructs a unified appreciation of how different group-living species coordinate their behaviors and why natural selection has produced these groups. For the first time, the book combines traditional approaches to behavioral ecology with ideas about self-organization and complex systems from physics and mathematics. Sumpter offers a guide for working with key models in this area along with case studies of their application, and he shows how ideas about animal behavior can be applied to understanding human social behavior. Containing a wealth of accessible examples as well as qualitative and quantitative features, Collective Animal Behavior will interest behavioral ecologists and all scientists studying complex systems.

Modeling Life
Modeling Life

Author: Alan Garfinkel

Publisher: Springer

Published: 2017-09-06

Total Pages: 456

ISBN-13: 3319597310

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This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?

Dynamic Models in Biology
Dynamic Models in Biology

Author: Stephen P. Ellner

Publisher: Princeton University Press

Published: 2011-09-19

Total Pages: 352

ISBN-13: 1400840961

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From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.

Trends in Teaching and Learning of Mathematical Modelling
Trends in Teaching and Learning of Mathematical Modelling

Author: Gabriele Kaiser

Publisher: Springer Science & Business Media

Published: 2011-06-23

Total Pages: 711

ISBN-13: 9400709102

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This book contains suggestions for and reflections on the teaching, learning and assessing of mathematical modelling and applications in a rapidly changing world, including teaching and learning environments. It addresses all levels of education from universities and technical colleges to secondary and primary schools. Sponsored by the International Community of Teachers of Mathematical Modelling and Applications (ICTMA), it reflects recent ideas and methods contributed by specialists from 30 countries in Africa, the Americas, Asia, Australia and Europe. Inspired by contributions to the Fourteenth Conference on the Teaching of Mathematical Modelling and Applications (ICTMA14) in Hamburg, 2009, the book describes the latest trends in the teaching and learning of mathematical modelling at school and university including teacher education. The broad and versatile range of topics will stress the international state-of-the-art on the following issues: Theoretical reflections on the teaching and learning of modelling Modelling competencies Cognitive perspectives on modelling Modelling examples for all educational levels Practice of modelling in school and at university level Practices in Engineering and Applications

Mathematical Modelling and Applications
Mathematical Modelling and Applications

Author: Gloria Ann Stillman

Publisher: Springer

Published: 2017-11-05

Total Pages: 620

ISBN-13: 3319629689

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This volume documents on-going research and theorising in the sub-field of mathematics education devoted to the teaching and learning of mathematical modelling and applications. Mathematical modelling provides a way of conceiving and resolving problems in the life world of people whether these range from the everyday individual numeracy level to sophisticated new problems for society at large. Mathematical modelling and real world applications are considered as having potential for multi-disciplinary work that involves knowledge from a variety of communities of practice such as those in different workplaces (e.g., those of educators, designers, construction engineers, museum curators) and in different fields of academic endeavour (e.g., history, archaeology, mathematics, economics). From an educational perspective, researching the development of competency in real world modelling involves research situated in crossing the boundaries between being a student engaged in modelling or mathematical application to real word tasks in the classroom, being a teacher of mathematical modelling (in or outside the classroom or bridging both), and being a modeller of the world outside the classroom. This is the focus of many of the authors of the chapters in this book. All authors of this volume are members of the International Community of Teachers of Mathematical Modelling (ICTMA), the peak research body into researching the teaching and learning of mathematical modelling at all levels of education from the early years to tertiary education as well as in the workplace.