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Author: Stanley E. Lazic
Publisher: Cambridge University Press
Published: 2016-12-08
Total Pages: 429
ISBN-13: 1107074290
DOWNLOAD EBOOKA guide to designing lab-based biological experiments that have low bias, high precision and widely applicable results.
Author: David J. Glass
Publisher: CSHL Press
Published: 2007
Total Pages: 211
ISBN-13: 0879697350
DOWNLOAD EBOOKThe effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.
Author: Gerry P. Quinn
Publisher: Cambridge University Press
Published: 2002-03-21
Total Pages: 851
ISBN-13: 1139432893
DOWNLOAD EBOOKAn essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data. The text begins with a revision of estimation and hypothesis testing methods, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models. Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models. Multivariate techniques, including classification and ordination, are then introduced. Special emphasis is placed on checking assumptions, exploratory data analysis and presentation of results. The main analyses are illustrated with many examples from published papers and there is an extensive reference list to both the statistical and biological literature. The book is supported by a website that provides all data sets, questions for each chapter and links to software.
Author: Stanley E. Lazic
Publisher: Cambridge University Press
Published: 2016-12-08
Total Pages: 429
ISBN-13: 1316810674
DOWNLOAD EBOOKSpecifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.
Author: David Heath
Publisher: CRC Press
Published: 1995-10-26
Total Pages: 372
ISBN-13: 1135370117
DOWNLOAD EBOOKThis illustrated textbook for biologists provides a refreshingly clear and authoritative introduction to the key ideas of sampling, experimental design, and statistical analysis. The author presents statistical concepts through common sense, non-mathematical explanations and diagrams. These are followed by the relevant formulae and illustrated by w
Author: Alastair C. Wardlaw
Publisher: Wiley
Published: 2000-04-07
Total Pages: 0
ISBN-13: 9780471988229
DOWNLOAD EBOOKA good working knowledge of statistical principles is needed for both the design and analysis of biological experiments and the subsequent handling of the large amounts of data generated if worthwhile, reliable conclusions are to be reached. Practical Statistics for Experimental Biologists, Second Edition provides biologists with a user-friendly, non-technical introduction to the basics of statistics. The book has been thoroughly revised and updated to incorporate: * Worked examples and printouts from MINITAB * Relevant case studies and applications * Further Notes section for background explanations Written by a biologist with extensive experience of applying statistical procedures to experimental systems, this book will be invaluable to undergraduates, postgraduates and researchers in microbiology, immunology, biochemistry, botany, zoology, physiology, pharmacology and pharmacy. Review of the First Edition "...strongly recommended as the current first choice both for students and established research workers." Society for General Microbiology Quarterly "...the book is refreshingly free from jargon, is well illustrated and is to be recommended." Trends in Biochemical Sciences "It is written in an easy style, and can be thoroughly recommended..." Trends in Pharmacological Sciences
Author: Bruno J. Strasser
Publisher: University of Chicago Press
Published: 2019-06-07
Total Pages: 421
ISBN-13: 022663518X
DOWNLOAD EBOOKDatabases have revolutionized nearly every aspect of our lives. Information of all sorts is being collected on a massive scale, from Google to Facebook and well beyond. But as the amount of information in databases explodes, we are forced to reassess our ideas about what knowledge is, how it is produced, to whom it belongs, and who can be credited for producing it. Every scientist working today draws on databases to produce scientific knowledge. Databases have become more common than microscopes, voltmeters, and test tubes, and the increasing amount of data has led to major changes in research practices and profound reflections on the proper professional roles of data producers, collectors, curators, and analysts. Collecting Experiments traces the development and use of data collections, especially in the experimental life sciences, from the early twentieth century to the present. It shows that the current revolution is best understood as the coming together of two older ways of knowing—collecting and experimenting, the museum and the laboratory. Ultimately, Bruno J. Strasser argues that by serving as knowledge repositories, as well as indispensable tools for producing new knowledge, these databases function as digital museums for the twenty-first century.
Author: Michael H. Herzog
Publisher: Springer
Published: 2019-08-13
Total Pages: 146
ISBN-13: 3030034992
DOWNLOAD EBOOKThis open access textbook provides the background needed to correctly use, interpret and understand statistics and statistical data in diverse settings. Part I makes key concepts in statistics readily clear. Parts I and II give an overview of the most common tests (t-test, ANOVA, correlations) and work out their statistical principles. Part III provides insight into meta-statistics (statistics of statistics) and demonstrates why experiments often do not replicate. Finally, the textbook shows how complex statistics can be avoided by using clever experimental design. Both non-scientists and students in Biology, Biomedicine and Engineering will benefit from the book by learning the statistical basis of scientific claims and by discovering ways to evaluate the quality of scientific reports in academic journals and news outlets.
Author:
Publisher:
Published: 2002
Total Pages: 537
ISBN-13: 9780511176210
DOWNLOAD EBOOKAn essential textbook for any biologist needing to design experiments, sampling programs or analyse the resulting data. Worked examples are used to illustrate the analyses and an extensive reference list provides links to the relevant biological and statistical literature. A supporting web-site contains datasets, questions and software links.
Author: Reiner Westermeier
Publisher: John Wiley & Sons
Published: 2008-09-08
Total Pages: 502
ISBN-13: 3527622306
DOWNLOAD EBOOKStill the only concise practical guide to laboratory experiments in proteomics, this new edition now also covers DIGE technology and liquid-chromatography, while the troubleshooting section has been considerably extended. Adopting a practical approach, the authors present the relevant techniques and explain the route to successful experimental design and optimal method selection. They cover such electrophoretic techniques as isoelectric focusing, SDS page, 2-D page, and DIGE, as well as liquid-chromatography techniques, such as ion exchange, affinity chromatography and reversed-phase HPLC. Mass-spectrometric techniques include MALDI, ESI, and FT ICR. Generously illustrated, partly in color, the book also features updates of protocols as well as animations illustrating crucial methodological steps on a companion website.
