Experimental Design for Biologists

Experimental Design for Biologists

Author: David J. Glass

Publisher: CSHL Press

Published: 2007

Total Pages: 211

ISBN-13: 0879697350

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The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.


Experimental Design and Data Analysis for Biologists

Experimental Design and Data Analysis for Biologists

Author: Gerry P. Quinn

Publisher: Cambridge University Press

Published: 2002-03-21

Total Pages: 851

ISBN-13: 1139432893

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An essential textbook for any student or researcher in biology needing to design experiments, sample programs or analyse the resulting data. The text begins with a revision of estimation and hypothesis testing methods, covering both classical and Bayesian philosophies, before advancing to the analysis of linear and generalized linear models. Topics covered include linear and logistic regression, simple and complex ANOVA models (for factorial, nested, block, split-plot and repeated measures and covariance designs), and log-linear models. Multivariate techniques, including classification and ordination, are then introduced. Special emphasis is placed on checking assumptions, exploratory data analysis and presentation of results. The main analyses are illustrated with many examples from published papers and there is an extensive reference list to both the statistical and biological literature. The book is supported by a website that provides all data sets, questions for each chapter and links to software.


Experimental Design for Laboratory Biologists

Experimental Design for Laboratory Biologists

Author: Stanley E. Lazic

Publisher: Cambridge University Press

Published: 2016-12-08

Total Pages: 429

ISBN-13: 1316810674

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Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.


An Introduction To Experimental Design And Statistics For Biology

An Introduction To Experimental Design And Statistics For Biology

Author: David Heath

Publisher: CRC Press

Published: 1995-10-26

Total Pages: 372

ISBN-13: 1135370117

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This illustrated textbook for biologists provides a refreshingly clear and authoritative introduction to the key ideas of sampling, experimental design, and statistical analysis. The author presents statistical concepts through common sense, non-mathematical explanations and diagrams. These are followed by the relevant formulae and illustrated by w


Experimental Design for the Life Sciences

Experimental Design for the Life Sciences

Author: Graeme D. Ruxton

Publisher:

Published: 2023

Total Pages: 0

ISBN-13: 9780191975202

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Providing students with clear and practical advice on how best to organise experiments and collect data so as to make the subsequent analysis easier and their conclusions more robust, this text assumes no specialist knowledge.


Statistical Methods in Biology

Statistical Methods in Biology

Author: S.J. Welham

Publisher: CRC Press

Published: 2014-08-22

Total Pages: 606

ISBN-13: 1439808783

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Written in simple language with relevant examples, Statistical Methods in Biology: Design and Analysis of Experiments and Regression is a practical and illustrative guide to the design of experiments and data analysis in the biological and agricultural sciences. The book presents statistical ideas in the context of biological and agricultural sciences to which they are being applied, drawing on relevant examples from the authors’ experience. Taking a practical and intuitive approach, the book only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat® statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R. By the time you reach the end of the book (and online material) you will have gained: A clear appreciation of the importance of a statistical approach to the design of your experiments, A sound understanding of the statistical methods used to analyse data obtained from designed experiments and of the regression approaches used to construct simple models to describe the observed response as a function of explanatory variables, Sufficient knowledge of how to use one or more statistical packages to analyse data using the approaches described, and most importantly, An appreciation of how to interpret the results of these statistical analyses in the context of the biological or agricultural science within which you are working. The book concludes with a guide to practical design and data analysis. It gives you the understanding to better interact with consultant statisticians and to identify statistical approaches to add value to your scientific research.


Sampling Design and Statistical Methods for Environmental Biologists

Sampling Design and Statistical Methods for Environmental Biologists

Author: Roger H. Green

Publisher: John Wiley & Sons

Published: 1979-05-01

Total Pages: 278

ISBN-13: 9780471039013

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Provides--in an organized and compact source--a comprehensive guide to the principles of sampling design and statistical analysis methods. Reviews the principles of inference, sampling and statistical design, and hypothesis formulation, all with special reference to ecological data. Includes an impact study illustrating the principles presented. Contains a key to five broad categories of environmental studies--as well as examples and examines specific topics that apply to any environmental study. Provides a comprehensive bibliography which is cross-referenced to the text and keyed to a specific topic code (types of methods and environments studied).


Experiments in Ecology

Experiments in Ecology

Author: A. J. Underwood

Publisher: Cambridge University Press

Published: 1997

Total Pages: 536

ISBN-13: 9780521556965

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First published in 1996, this book is a logical and consistent approach to experimental design using statistical principles.


Quality by Experimental Design

Quality by Experimental Design

Author: Thomas B. Barker

Publisher: CRC Press

Published: 2016-01-27

Total Pages: 740

ISBN-13: 1482249677

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Achieve Technological Advancements in Applied Science and Engineering Using Efficient Experiments That Consume the Least Amount of ResourcesWritten by longtime experimental design guru Thomas B. Barker and experimental development/Six Sigma expert Andrew Milivojevich, Quality by Experimental Design, Fourth Edition shows how to design and analyze ex


Foundational and Applied Statistics for Biologists Using R

Foundational and Applied Statistics for Biologists Using R

Author: Ken A. Aho

Publisher: CRC Press

Published: 2016-03-09

Total Pages: 598

ISBN-13: 1439873399

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Full of biological applications, exercises, and interactive graphical examples, this text presents comprehensive coverage of both modern analytical methods and statistical foundations. The author harnesses the inherent properties of the R environment to enable students to examine the code of complicated procedures step by step and thus better understand the process of obtaining analysis results. The graphical capabilities of R are used to provide interactive demonstrations of simple to complex statistical concepts. R code and other materials are available online.