Evaluation of Sixteen Antimotion Sickness Drugs Under Controlled Laboratory Conditions
Evaluation of Sixteen Antimotion Sickness Drugs Under Controlled Laboratory Conditions

Author: Charles D. Wood

Publisher:

Published: 1968

Total Pages: 24

ISBN-13:

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The effectiveness of a drug in reducing susceptibility to acute motion sickness is readily determined in a slow rotation room (SRR) where the stressful Coriolis accelerations are under quantitative control and the experimenter and subject can collaborate under laboratory conditions. Fifty subjects were used, each serving as his own control, in evaluating 16 representative antimotion sickness drugs. Only the drugs with a sympathomimetic or parasympatholytic action and some of the antihistamines were notably effective. The summation effect of dextroamphetamine sulfate and 1-scopolamine hydrobromide provided far better protection than any single drug. Other classes of drugs had either a slightly favorable or slightly unfavorable action. (Author).

Evaluation of Antimotion Sickness Drugs: a New Effective Remedy Revealed
Evaluation of Antimotion Sickness Drugs: a New Effective Remedy Revealed

Author: Charles D. Wood

Publisher:

Published: 1970

Total Pages: 16

ISBN-13:

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Three single drugs (one used in three dosage levels) and three drug combinations were compared in their effectiveness to prevent motion sickness under standarized stress conditions in a slow rotation room. An unexpected finding was that a combination of promethazine 25 mg with d-amphetamine 10 mg had the same range of effectiveness as that found in earlier studies (and confirmed here) for scopolamine 0.6 mg plus d-amphetamine 10 mg. When scopolamine was tested alone, halving the 'usual' dose (0.6 mg) reduced its effectiveness about one-fifth and doubling the usual dose increased effectiveness by 29 per cent; thus, the optimum dose of scopolamine appeared to be approximately 0.5 mg. Betahistine hydrochloride (4 mg) was ineffective and cinnarizine (50 mg) was of small benefit. (Author).

Evaluation of Sixteen Antimotion Sickness Drugs Under Controlled Laboratory Conditions
Evaluation of Sixteen Antimotion Sickness Drugs Under Controlled Laboratory Conditions

Author: Charles D. Wood

Publisher:

Published: 1968

Total Pages: 15

ISBN-13:

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The effectiveness of a drug in reducing susceptibility to acute motion sickness is readily determined in a slow rotation room (SRR) where the stressful Coriolis accelerations are under quantitative control and the experimenter and subject can collaborate under laboratory conditions. Fifty subjects were used, each serving as his own control, in evaluating 16 representative antimotion sickness drugs. Only the drugs with a sympathomimetic or parasympatholytic action and some of the antihistamines were notably effective. The summation effect of dextroamphetamine sulfate and 1-scopolamine hydrobromide provided far better protection than any single drug. Other classes of drugs had either a slightly favorable or slightly unfavorable action. (Author).

Aerospace Medicine and Biology
Aerospace Medicine and Biology

Author:

Publisher:

Published: 1988

Total Pages: 254

ISBN-13:

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A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).

Principles of Clinical Medicine for Space Flight
Principles of Clinical Medicine for Space Flight

Author: Michael R. Barratt

Publisher: Springer Science & Business Media

Published: 2008-03-20

Total Pages: 592

ISBN-13: 0387681647

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Over the years, a large body of knowledge has developed regarding the ways in which space flight affects the health of the personnel involved. Now, for the first time, this clinical knowledge on how to diagnose and treat conditions that either develop during a mission or because of a mission has been compiled by Drs. Michael Barratt and Sam L. Pool of the NASA/Johnson Space Center. Complete with detailed information on the physiological and psychological affects of space flight as well as how to diagnose and treat everything from dental concerns to decompression to dermatological problems encountered, this text is a must have for all those associated with aerospace medicine.

Comparison of Five Levels of Motion Sickness Severity as the Basis for Grading Susceptibility
Comparison of Five Levels of Motion Sickness Severity as the Basis for Grading Susceptibility

Author: Earl F. Miller (II)

Publisher:

Published: 1970

Total Pages: 28

ISBN-13:

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The Coriolis (motion) sickness susceptibility index (CSSI) of 275 healthy male subjects was calculated from data obtained by a standardized laboratory procedure at each of five specific levels of motion sickness severity, viz, frank sickness (FS), severe malaise (M III), moderate malaise (M IIA and M IIB), and mild malaise (M I). The stressor value (E factor) of a single standardized head movement associated with each rotational rate of the test chair was adjusted to yield an equivalent CSSI score independent of the endpoint selected. Close agreement among the CSSI scores obtained at each endpoint was found in intercorrelations, test-retest reliability coefficients (N = 30), and frequency distributions that reflected the orderliness and stability in the appearance, ramification, and intensification of the acute symptomatology evoked in progressing from M I to FS. The endpoint M IIA appeared, however, to yield the best balance between subject acceptability and test confidence, and was used without exception to calibrate the motion sickness susceptibility of 250 additional subjects. (Author).

A Comparison of Some Effects of Three Antimotion Sickness Drugs on Nystagmic Responses to Angular Accelerations and to Optokinetic Stimuli
A Comparison of Some Effects of Three Antimotion Sickness Drugs on Nystagmic Responses to Angular Accelerations and to Optokinetic Stimuli

Author: William Edward Collins

Publisher:

Published: 1981

Total Pages: 30

ISBN-13:

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This study examined the influence of three established antimotion sickness drugs on nystagmic eye movement responses to angular acceleration (whole-body movement) with vision either permitted or denied, and to optokinetic stimulation (visual field movement). Dimenhydrinate and promethazine hydrochloride, particularly at higher does levels, reduced optokinetic nystagmus, thereby making less accurate the following ability of the eye. During whole-body motion in darkness, there was little placebo-drug difference in the vestibular response under alert conditions; under relaxed conditions, dimenhydrinate and promethazine hydrochloride produced significant declines in the vestibular eye movements. These same drugs also interfered with the ability of the individual to fixate adequately on a visual task during motion. Subjects who received a combination of promethazine plus d-amphetamine were able to suppress vestibular eye movements under the task condition and maintain good visual fixation. Thus, the effect of a drug on nystagmus may be a poor indicator of its value in preventing motion sickness. Moreover, assessments of antimotion sickness drugs for many practical situations should include as a possible adverse side effect the inability to maintain visual fixation during motion.