Estrogen/antiestrogen Action and Breast Cancer Therapy
Estrogen/antiestrogen Action and Breast Cancer Therapy

Author: Virgil Craig Jordan

Publisher: Univ of Wisconsin Press

Published: 1986

Total Pages: 564

ISBN-13: 9780299104801

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This book marks one of the achievements of the "Estrogen and Antiestrogen Action: Basic and Clinical Aspects" Wisconsin Clinical Cancer Center conference in June 1984. It is not intended to be a recount of the meeting proceedings but is, rather, a historical review of the development of this field of endeavor during the past 30 years. The chapters have been written by many of the leading experts in the field who were asked to recount the development of a particular area or laboratory idea in which they had been personally involved. The book is intended to provide both scientists and clinicians with a single-volume overview of both the basic principles of hormonal control of breast cancer and the recent clinical results from cooperative groups around the world.

Medicinal Chemistry of Anticancer Drugs
Medicinal Chemistry of Anticancer Drugs

Author: Carmen Avendaño

Publisher: Elsevier

Published: 2015-06-11

Total Pages: 767

ISBN-13: 0444626670

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Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Tamoxifen
Tamoxifen

Author: Philipp Y. Maximov

Publisher: Springer Science & Business Media

Published: 2013-07-23

Total Pages: 218

ISBN-13: 3034806647

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Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Gene Activation by Antiestrogens Used in Breast Cancer Therapy Via the Interaction of Estrogen Receptor and AP-1
Gene Activation by Antiestrogens Used in Breast Cancer Therapy Via the Interaction of Estrogen Receptor and AP-1

Author:

Publisher:

Published: 1997

Total Pages: 34

ISBN-13:

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Progestins and glucocorticoids are sometimes used as second line therapy for breast cancer that has become resistant to antiestrogens. We investigated whether the opposing actions of estrogens and glucocorticoids (or progestins) might reflect the opposing actions of hormone bound receptors on target genes regulated by the AP-l response element. We found that estrogens stimulate, while the glucocorticoid dexamethasone (Dex) inhibits, transcription through a model promoter from the collagenase gene ( -73 to +63 bearing a consensus AP- 1 response element. Together the hormones counteracted each others effects, and the amount of transfected receptor for estrogen (ER) or glucocorticoid (GR) determined which prevailed. Dex also inhibited tamoxifen activated AP-l. Both progesterone receptor -A and -B also interacted with the ER at the A')- 1 site. These data indicate that opposing steroid influences can be mediated at the level of transcription through the A')- 1 site and suggest that the integration of hormone action at this response element may underlie some of the opposing actions of estrogens and glucocorticoids or progestins on physiologic responses.

Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And Promise
Estrogen Action, Selective Estrogen Receptor Modulators And Women's Health: Progress And Promise

Author: V Craig Jordan

Publisher: World Scientific

Published: 2013-05-27

Total Pages: 544

ISBN-13: 1848169590

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This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

Estrogen Receptor and Breast Cancer
Estrogen Receptor and Breast Cancer

Author: Xiaoting Zhang

Publisher:

Published: 2019

Total Pages: 417

ISBN-13: 9783319993515

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The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Selective Estrogen Receptor Modulators
Selective Estrogen Receptor Modulators

Author: Andrea Manni

Publisher: Springer Science & Business Media

Published: 2002-01-18

Total Pages: 417

ISBN-13: 1592591574

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Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

Estrogens, Estrogen Receptor and Breast Cancer
Estrogens, Estrogen Receptor and Breast Cancer

Author: Fritz F. Parl

Publisher: IOS Press

Published: 2000

Total Pages: 280

ISBN-13: 9780967335544

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Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.