Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.
This fully updated thirteenth edition of Simpson's Forensic Medicine remains a classic introductory text to the field. Continuing its tradition of preparing the next generation of forensic practitioners, it presents essential concepts in the interface between medicine and the law. Twenty-four chapters cover basic science, toxicology, forensic odont
Fifty years after the founding of NASA, from 28 to 29 October 2008, the NASA History Division convened a conference whose purpose was a scholarly analysis of NASA's first 50 years. Over two days at NASA Headquarters, historians and policy analysts discussed NASA's role in aeronautics, human spaceflight, exploration, space science, life science, and Earth science, as well as crosscutting themes ranging from space access to international relations in space and NASA's interaction with the public. The speakers were asked to keep in mind the following questions: What are the lessons learned from the first 50 years? What is NASA's role in American culture and in the history of exploration and discovery? What if there had never been a NASA? Based on the past, does NASA have a future? The results of those papers, elaborated and fully referenced, are found in this 50th anniversary volume. The reader will find here, instantiated in the complex institution that is NASA, echoes of perennial themes elaborated in an earlier volume, Critical Issues in the History of Spaceflight. The conference culminated a year of celebrations, beginning with an October 2007 conference celebrating the 50th anniversary of the Space Age and including a lecture series, future forums, publications, a large presence at the Smithsonian Folklife Festival, and numerous activities at NASA's 10 Centers and venues around the country. It took place as the Apollo 40th anniversaries began, ironically still the most famous of NASA's achievements, even in the era of the Space Shuttle, International Space Station (ISS), and spacecraft like the Mars Exploration Rovers (MERs) and the Hubble Space Telescope. And it took place as NASA found itself at a major crossroads, for the first time in three decades transitioning, under Administrator Michael Griffin, from the Space Shuttle to a new Ares launch vehicle and Orion crew vehicle capable of returning humans to the Moon and proceeding to Mars in a program known as Constellation. The Space Shuttle, NASA's launch system since 1981, was scheduled to wind down in 2010, freeing up funds for the new Ares launch vehicle. But the latter, even if it moved forward at all deliberate speed, would not be ready until 2015, leaving the unsettling possibility that for at least five years the United States would be forced to use the Russian Soyuz launch vehicle and spacecraft as the sole access to the ISS in which the United States was the major partner. The presidential elections a week after the conference presaged an imminent presidential transition, from the Republican administration of George W. Bush to (as it turned out) the Democratic presidency of Barack Obama, with all the uncertainties that such transitions imply for government programs. The uncertainties for NASA were even greater, as Michael Griffin departed with the outgoing administration and as the world found itself in an unprecedented global economic downturn, with the benefits of national space programs questioned more than ever before. There was no doubt that 50 years of the Space Age had altered humanity in numerous ways ranging from applications satellites to philosophical world views. Throughout its 50 years, NASA has been fortunate to have a strong sense of history and a robust, independent, and objective history program to document its achievements and analyze its activities. Among its flagship publications are Exploring the Unknown: Selected Documents in the History of the U.S. Civil Space Program, of which seven of eight projected volumes were completed at the time of the 50th anniversary. The reader can do no better than to turn to these volumes for an introduction to NASA history as seen through its primary documents. The list of NASA publications at the end of this volume is also a testimony to the tremendous amount of historical research that the NASA History Division has sponsored over the last 50 years, of which this is the latest volume.
Documenting how in the course of acquiring language children become speakers and members of communities, The Handbook of Language Socialization is a unique reference work for an emerging and fast-moving field. Spans the fields of anthropology, education, applied linguistics, and human development Includes the latest developments in second and heritage language socialization, and literary and media socialization Discusses socialization across the entire life span and across institutional settings, including families, schools, work places, and churches Explores data from a multitude of cultures from around the world
The authors contemplate the origins, architecture and commercial growth of wayside eateries in the US over the past 100 years. Fast Food examines the impact of the automobile on the restaurant business and offers an account of roadside dining.
This is a book about readers on the move in the age of Victorian empire. It examines the libraries and reading habits of five reading constituencies from the long nineteenth century: shipboard emigrants, Australian convicts, Scottish settlers, polar explorers, and troops in the First World War. What was the role of reading in extreme circumstances? How were new meanings made under strange skies? How was reading connected with mobile communities in an age of expansion? Uncovering a vast range of sources from the period, from diaries, periodicals, and literary culture, Bill Bell reveals some remarkable and unanticipated insights into the way that reading operated within and upon the British Empire for over a century.
