Cell Polarity in Development and Disease
Cell Polarity in Development and Disease

Author: Douglas W Houston

Publisher: Academic Press

Published: 2017-11-14

Total Pages: 238

ISBN-13: 0128125918

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Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. - Provides basic science understanding of cell polarity disease and development - Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer - Includes historical context of cell polarity research for potential future breakthroughs

Epithelial Morphogenesis in Development and Disease
Epithelial Morphogenesis in Development and Disease

Author: Walter Birchmeier

Publisher: CRC Press

Published: 2003-09-02

Total Pages: 395

ISBN-13: 1482283506

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Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelia, this volume represents a timely and valuable contribution to a growing field of study.

Extracellular Matrix in Development
Extracellular Matrix in Development

Author: Douglas W. DeSimone

Publisher: Springer Science & Business Media

Published: 2013-03-15

Total Pages: 260

ISBN-13: 3642359353

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Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Branching Morphogenesis
Branching Morphogenesis

Author: Jamie Davies

Publisher: Springer Science & Business Media

Published: 2007-03-20

Total Pages: 255

ISBN-13: 0387308733

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Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.

Mammalian Development
Mammalian Development

Author: Patrick P. L. Tam

Publisher:

Published: 2013

Total Pages: 0

ISBN-13: 9781936113248

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"A subject collection from Cold Spring Harbor perspectives in biology."

Kidney Development and Disease
Kidney Development and Disease

Author: Rachel K. Miller

Publisher: Springer

Published: 2017-04-13

Total Pages: 373

ISBN-13: 3319514369

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Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Epithelial Morphogenesis in Development and Disease
Epithelial Morphogenesis in Development and Disease

Author: Walter Birchmeier

Publisher: CRC Press

Published: 2003-09-02

Total Pages: 395

ISBN-13: 0203303768

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Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelia, this volume represents a timely and valuable contribution to a growing field of study.

Developmental Biology: A Very Short Introduction
Developmental Biology: A Very Short Introduction

Author: Lewis Wolpert

Publisher: Oxford University Press

Published: 2011-08-25

Total Pages: 153

ISBN-13: 0199601194

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"A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.

Fetal and Neonatal Lung Development
Fetal and Neonatal Lung Development

Author: Alan H. Jobe

Publisher: Cambridge University Press

Published: 2016-04-18

Total Pages:

ISBN-13: 1316665178

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Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.

Rise and Fall of Epithelial Phenotype
Rise and Fall of Epithelial Phenotype

Author: Pierre Savagner

Publisher: Springer Science & Business Media

Published: 2007-07-05

Total Pages: 341

ISBN-13: 0387286713

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Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.