Epidemiological Research: Terms and Concepts

Epidemiological Research: Terms and Concepts

Author: O. S. Miettinen

Publisher: Springer Science & Business Media

Published: 2011-04-22

Total Pages: 181

ISBN-13: 9400711719

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The book is organized so as to address in separate sections first the preparatory topics of medicine (clinical and epidemiological), science in general, and statistics (mathematical); then topics of epidemiological research proper; and, finally, topics of ‘meta-epidemiological’ clinical research. In those two main sections, a further grouping is based on the distraction between objects and methods of study. In this framework, the particular topics are addressed both descriptively and quasi-prescriptively, commonly with a number of explicatory annotations. This book is intended to serve as a handbook for whomever is, in whatever way, concerned with epidemiological or ‘meta-epidemiological’ clinical research. But besides this, it is also intended to serve as a textbook for students in introductory courses on ‘epidemiological’ research – to which end there is a suggested hierarchy of the concepts that might reasonably be covered.


Concepts of Epidemiology

Concepts of Epidemiology

Author: Raj S. Bhopal

Publisher: Oxford University Press

Published: 2016

Total Pages: 481

ISBN-13: 0198739680

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First edition published in 2002. Second edition published in 2008.


Epidemiological Research: An Introduction

Epidemiological Research: An Introduction

Author: O. S. Miettinen

Publisher: Springer Science & Business Media

Published: 2012-07-25

Total Pages: 188

ISBN-13: 9400745370

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Having last year published “Up from Clinical Epidemiology & EBM” and also “Epidemiological Research: Terms and Concepts,” Miettinen now – this time with collaboration from his junior colleague I. Karp – brings out this further introduction into epidemiological research; and he is now working on an introduction into clinical research, for publication next year. It evidently is Miettinen’s felt time to crystallize the basic understandings he has come to as the culmination of a half-century of concentrated effort to advance the theory of epidemiological and ‘meta-epidemiological clinical’ research. In accord with its title, this book focuses on research to develop the knowledge-base for preventive medicine, which mainly is knowledge about the causal origin –etilogy, etiogenesis – of illness. It first illustrates how wanting this knowledge still is, despite much research; and it then aims to guide the reader to more productive etiogenetic research. This book places much emphasis on the need to assure relevance by principles-guided objects design for the studies, which now remains conspicuously absent from epidemiologists’ concerns. And as for methods design, this book exposes the fallacies in the still-common ‘cohort’ and ‘case-control’ studies, defines the essentials of all etiogenetic studies, and then addresses the true options for design in this framework of shared essentials. A good deal of attention is also given to the still commonly-held, very major, twin fallacies that screening for an illness is a preventive intervention, to be studied by randomized trials, and that research on it can imply rational guidelines or recommendations regarding decisions about the screening. While Miettinen already is regarded as ‘the father of modern epidemiology,’ he now appears to have become the father also of post-modern epidemiology, where ‘epidemiology’ still means epidemiological research.


Analysis of Cancer Risks in Populations Near Nuclear Facilities

Analysis of Cancer Risks in Populations Near Nuclear Facilities

Author: National Research Council

Publisher: National Academies Press

Published: 2012-06-29

Total Pages: 424

ISBN-13: 0309255716

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In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.


Epidemiology: Principles and Practical Guidelines

Epidemiology: Principles and Practical Guidelines

Author: Jan Van den Broeck

Publisher: Springer Science & Business Media

Published: 2013-04-22

Total Pages: 622

ISBN-13: 9400759894

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This textbook presents epidemiology in a practical manner, contextualized with discussions of theory and ethics, so that students and professionals from all academic backgrounds may develop a deep appreciation for how to conduct and interpret epidemiological research. Readers will develop skills to: -Search for and appraise literature critically, -Develop important research questions, -Design and implement studies to address those questions, -Perform and interpret fundamental statistical estimations and tests, -Consider the ethical implications of all stages of research, -Report findings in publications, and -Advocate for change in the public health setting. Epidemiology is and will remain a discipline in motion, and this textbook aims at reflecting this dynamism and keeping pace with its momentum. This textbook is not only a classroom tool with high utility but also an essential reference and guide for those engaging in research involving human subjects.


Epidemiological Research Methods

Epidemiological Research Methods

Author: Donald R. McNeil

Publisher: John Wiley & Sons

Published: 1996-08-06

Total Pages: 320

ISBN-13: 9780471961963

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The concepts of epidemiology, the science that uses statistical methods to investigate associations between risk factors and disease outcomes in human populations, are developed using examples involving real data from published studies. The relevant statistical methods are developed systematically to provide an integrated approach to observational and experimental studies. After covering basic measurement, study design, and study credibility issues, the author continues with basic statistical methods and techniques for adjusting risk estimates for confounders. Statistical models including logistic regression and the proportional hazards model for survival analysis are explained in detail in the following chapters, concluding with an explanation of the general methods for determining the sample size and power requirements for an epidemiological study. Taking advantage of the power, accessibility and user-friendliness of modern computer packages, the author uses a variety of interesting data sets and graphical displays to illustrate the methods. Epidemiological Research Methods will be of interest to students and research workers who need to learn and appreciate modern approaches to the subject. Without unnecessary emphasis on mathematics or theory, the book will enable the reader to gain a greater level of understanding of the underlying methods than is normally provided in books on epidemiology.


Epidemiology and Biostatistics

Epidemiology and Biostatistics

Author: Bryan Kestenbaum

Publisher: Springer Science & Business Media

Published: 2009-08-28

Total Pages: 242

ISBN-13: 0387884335

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Concise, fast-paced, intensive introduction to clinical research design for students and clinical research professionals Readers will gain sufficient knowledge to pass the United States Medical Licensing Examination part I section in Epidemiology


Epidemiology

Epidemiology

Author: Moon, Graham

Publisher: McGraw-Hill Education (UK)

Published: 2000-08-01

Total Pages: 210

ISBN-13: 0335200125

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This text offers a comprehensive insight into the methods and principles of epidemological study alongside an analysis of the broad context in which epidemiological work is undertaken.


A Dictionary of Epidemiology

A Dictionary of Epidemiology

Author: Miquel S. Porta

Publisher: Oxford University Press

Published: 2014

Total Pages: 377

ISBN-13: 0199976724

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This edition is the most updated since its inception, is the essential text for students and professionals working in and around epidemiology or using its methods. It covers subject areas - genetics, clinical epidemiology, public health practice/policy, preventive medicine, health promotion, social sciences and methods for clinical research.


Small Clinical Trials

Small Clinical Trials

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-01-01

Total Pages: 221

ISBN-13: 0309171148

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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.