Enzymes
Author: Howard F. Loomis
Publisher:
Published: 2005
Total Pages: 232
ISBN-13:
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Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publisher: CRC Press
Published: 2019-06-27
Total Pages: 456
ISBN-13: 1000021289
DOWNLOAD EBOOKThis book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.
The Exocrine Pancreas
Author: Stephen Pandol
Publisher: Morgan & Claypool Publishers
Published: 2011
Total Pages: 66
ISBN-13: 1615041389
DOWNLOAD EBOOKThe secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
Enzymes for Solving Humankind's Problems
Author: José J. G. Moura
Publisher: Springer Nature
Published: 2020-12-01
Total Pages: 507
ISBN-13: 3030583155
DOWNLOAD EBOOKThis book presents specific key natural and artificial systems that are promising biocatalysts in the areas of health, agriculture, environment and energy. It provides a comprehensive account of the state of the art of these systems and outlines the significant progress made in the last decade using these systems to develop innovative, sustainable and environmentally friendly solutions. Chapters from expert contributors explore how natural enzymes and artificial systems tackle specific targets such as: climate change, carbon footprint and economy and carbon dioxide utilisation; nitrogen footprint and fixation and nitrous oxide mitigation; hydrogen production, fuel cells and energy from bacteria; biomass transformation and production of added-value compounds, as well as biosensors development. This book provides an important and inspiring account for the designing of new natural and artificial systems with enhanced properties, and it appeals not only to students and researchers working in the fields of energy, health, food and environment, but also to a wider audience of educated readers that are interested in these up-to-date and exciting subjects. Chapter “Carbon Dioxide Utilisation—The Formate Route” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Pancreatic Enzymes in Health and Disease
Author: Paul G. Lankisch
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 314
ISBN-13: 364276097X
DOWNLOAD EBOOKDieses Buch pr{sentiert neueste Forschungsergebnisse zur Be- deutung von Pankreasenzymen f}r die normale Verdauung und untersucht die Notwendigkeit der Enzymsubstitution bei Un- terfunktion und Erkrankungen des Pankreas.
Food Enzymes for Health & Longevity
Author: Edward Howell
Publisher: Lotus Press (WI)
Published: 2015-01-07
Total Pages: 0
ISBN-13: 9780940676275
DOWNLOAD EBOOKWith an expanded introduction by Viktoras Kulvinskas, this new, enlarged edition of the classic book contains over 400 references to scientific literature that contributed to the formulation of Dr. Howell's revolutionary "food enzyme concept." The second edition incorporated an interview of the author by Viktoras Kulvinskas. There is also an extensive new foreword by Viktoras Kulvinskas that has been added to this revised 3rd edition, as well as a new research appendix at the end. The foreword adds a very substantial body of recent and updated research to support the food enzyme concept of Dr. Howell and underline the importance of food enzymes.
Glutathione System and Oxidative Stress in Health and Disease
Author:
Publisher: BoD – Books on Demand
Published: 2020-08-26
Total Pages: 140
ISBN-13: 1838801251
DOWNLOAD EBOOKThe imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Enzymes: A Very Short Introduction
Author: Paul Engel
Publisher: Oxford University Press
Published: 2020-11-26
Total Pages: 152
ISBN-13: 0192558803
DOWNLOAD EBOOKEnzymes are the astonishing, tiny molecular machines that make life possible. Each one of these small proteins speeds up a single chemical reaction inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that collectively we recognise as life, from making DNA to digesting food. This Very Short Introduction explains the why and the how of speeding up these reactions - catalysis - before going on to reveal how we have evolved these catalysts of such extraordinary power and exquisite selectivity. Paul Engel shows how X-ray crystallography has revealed the complex molecular shapes that allow enzymes to function at an extraordinarily sophisticated level. He also examines medical aspects of enzymes, both in the way faulty enzymes cause disease and in the way enzymes can be used for diagnosis and therapy. Finally, he looks at the many varied ways in which individual enzymes, taken out of their biological context, are used nowadays as tools - in washing powders, food production, waste treatment, and chemical synthesis. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Enzymes
Author: D. A. Lopez
Publisher:
Published: 1994
Total Pages: 354
ISBN-13: 9781884303005
DOWNLOAD EBOOKReviews the role of enzymes in health and disease, with emphasis on their importance in maintaining our health, disease prevention and their uses in medicine.
Fabry Disease
Author: Deborah Elstein
Publisher: Springer Science & Business Media
Published: 2010-08-02
Total Pages: 525
ISBN-13: 9048190339
DOWNLOAD EBOOKFabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
