Enantioselective C-C Bond Forming Reactions
Enantioselective C-C Bond Forming Reactions

Author:

Publisher: Elsevier

Published: 2023-12-01

Total Pages: 338

ISBN-13: 044323700X

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Enantioselective C-C Bond Forming Reactions: From Metal Complex-, Organo-, and Bio-catalyzed Perspectives, Volume 73 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as An introduction to Chirality, Metal-catalyzed stereoselective C-C-bond forming reactions, Enantioselective C-C bond forming reactions promoted by organocatalysts based on unnatural amino acid derivatives, Enantioselective C-C bond formation in complex multicatalytic system, Gold-based multicatalytic systems for enantioselective C-C Bond forming reactions, Novel enzymatic tools for C-C bond formation through the development of new-to-nature biocatalysis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Catalysis serials - Updated release includes the latest information in the field

Enantioselective Organocatalyzed Reactions II
Enantioselective Organocatalyzed Reactions II

Author: Rainer Mahrwald

Publisher: Springer Science & Business Media

Published: 2011-08-03

Total Pages: 400

ISBN-13: 9048138671

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Organocatalyzed Reactions I and II presents a timely summary of organocatalysed reactions including: a) Enantioselective C-C bond formation processes e.g. Michael-addition, Mannich-reaction, Hydrocyanation (Strecker-reaction), aldol reaction, allylation, cycloadditions, aza-Diels-Alder reactions, benzoin condensation, Stetter reaction, conjugative Umpolung, asymmetric Friedel-Crafts reactions; b) Asymmetric enantioselective reduction processes e.g. Reductive amination of aldehydes or ketones, asymmetric transfer hydrogenation; c) Asymmetric enantioselective oxidation processes; d) Asymmetric epoxidation, Bayer-Villiger oxidation; e) Enantioselective a-functionalization; f) A-alkylation of ketones, a-halogenation and a-oxidation of carbonyl compounds.

P-stereogenic Ligands in Enantioselective Catalysis
P-stereogenic Ligands in Enantioselective Catalysis

Author: Arnald Grabulosa

Publisher: Royal Society of Chemistry

Published: 2011

Total Pages: 521

ISBN-13: 1849731233

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P-stereogenic ligands were among the first to be used in asymmetric catalysis but synthetic difficulties and prejudices have hampered their development. However, continuous screening for new chiral ligands means that they can no longer be ignored and this rigorous reference source reflects their renaissance.The book is filled with many examples from recent primary literature. The synthetic chemist will easily be able to follow the preparation methods which are accompanied by a description of the challenges and limitations. Those working in homogenous catalysis, and wanting to increase their repertoire of ligands, will be able to establish which have already been used in each reaction and their performance.This book provides comprehensive coverage of the application of P-stereogenic ligands in homogeneous catalysis. It begins with a brief chapter on generalities of P-stereogenic compounds: history, configurational stability, and interconversions among them.The book then goes on to describe the main preparative methods, from resolution of racemates to enantioselective catalysis, before focusing on the catalytic applications of P-stereogenic ligands. Chapter 7 describes the use of the ligands in catalytic hydrogenation and related reactions whereas chapter 8 deals with other reactions, mainly C-C bond forming reactions. The aim of these two final chapters is to give an outline of the usefulness of the ligands in homogeneous catalysis.

C-H Activation for Asymmetric Synthesis
C-H Activation for Asymmetric Synthesis

Author: Françoise Colobert

Publisher: John Wiley & Sons

Published: 2019-11-12

Total Pages: 294

ISBN-13: 3527343407

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Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.

Transition-Metal-Mediated Aromatic Ring Construction
Transition-Metal-Mediated Aromatic Ring Construction

Author: Ken Tanaka

Publisher: John Wiley & Sons

Published: 2013-07-09

Total Pages: 785

ISBN-13: 111862999X

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State-of-the-science methods, synthetic routes, and strategies to construct aromatic rings The development of new reactions for the synthesis of aromatic compounds is a highly active research area in organic synthesis, providing new functional organic materials, functional reagents, and biologically active compounds. Recently, significant advances in transition-metal-mediated reactions have enabled the efficient and practical construction of new aromatic rings with useful properties and applications. This book draws together and reviews all the latest discoveries and methods in transition-metal-mediated reactions, offering readers promising new routes to design and construct complex aromatic compounds. Integrating metal catalysis with aromatic compound synthesis, Transition-Metal-Mediated Aromatic Ring Construction offers a practical guide to the methods, synthetic routes, and strategies for constructing aromatic compounds. The book's five parts examine: [2+2+2], [2+2+1], and related cycloaddition reactions [4+2], [3+2], and related cycloaddition reactions Electrocyclization reactions Coupling and addition reactions Other important transformations, including methathesis reactions and skeletal rearrangement reactions Edited by Ken Tanaka, an internationally recognized expert in the field of transition-metal catalysis, the book features authors who are leading pioneers and researchers in synthetic reactions. Their contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience developing new aromatic compounds. All chapters end with a summary and outlook, setting forth new avenues of research and forecasting new discoveries. There are also references at the end of each chapter, guiding readers to important original research reports and reviews. In summary, Transition-Metal-Mediated Aromatic Ring Construction offers synthetic chemists a promising new avenue for the development of important new aromatic compounds with a broad range of applications.

New Frontiers in Asymmetric Catalysis
New Frontiers in Asymmetric Catalysis

Author: Koichi Mikami

Publisher: John Wiley & Sons

Published: 2007-02-16

Total Pages: 436

ISBN-13: 047009799X

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A compilation of recent advances and applications in asymmetric catalysis The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers: * "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation) * Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis * Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis * Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.

C-X Bond Formation
C-X Bond Formation

Author: Arkadi Vigalok

Publisher: Springer

Published: 2010-06-30

Total Pages: 198

ISBN-13: 3642120733

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Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.

New Trends in Asymmetric Catalysis
New Trends in Asymmetric Catalysis

Author: Giorgio Della Sala

Publisher: MDPI

Published: 2021-08-30

Total Pages: 172

ISBN-13: 3036509720

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The synthesis of enantiopure organic compounds is a key issue for several applications in pharmacology, food chemistry, agricultural chemistry, perfumery, materials science and other industrial sectors. Nowadays, asymmetric catalysis is undoubtedly the most important tool to achieve this goal. This technology, in fact, enables the production of large amounts of enantiomerically enriched compounds, employing relatively small quantities of chiral enantiopure catalysts, which is exactly what is accomplished by enzymes in nature. Since the pioneering works of Noyori, Knowles and Sharpless, which later earned them the Nobel Prize in Chemistry, asymmetric catalysis has experienced a rapid and relentless development in the last fifty years. The tremendous expansion of enantioselective transformations, the design of novel and more efficient organometallic and organic catalysts, the development of sophisticated bioreactors and cell factories, are just some of the elements responsible for such growth. However, new challenges of asymmetric catalysis are devoted to enhancing the process’s sustainability, by the introduction of recyclable and low-cost catalysts, and the use of renewable starting materials and energy source. This book provides an overview of some of these development directions and comprises a collection of review papers and a research article authored by renowned researchers actively involved in this field. The topics covered by the review papers are photoredox-catalyzed reactions of imines, asymmetric catalytic electrosynthesis, cooperative catalysis of chiral N-heterocyclic carbenes and Lewis acid, and asymmetric ring-opening reactions of epoxides catalyzed by metal–salen complexes. The research article presents a proline-catalyzed aldol reaction in water–methanol solvent mixture.

Multicatalyst System in Asymmetric Catalysis
Multicatalyst System in Asymmetric Catalysis

Author: Jian Zhou

Publisher: John Wiley & Sons

Published: 2014-10-03

Total Pages: 712

ISBN-13: 1118846931

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This book introduces multi-catalyst systems by describing their mechanism and advantages in asymmetric catalysis. • Helps organic chemists perform more efficient catalysis with step-by-step methods • Overviews new concepts and progress for greener and economic catalytic reactions • Covers topics of interest in asymmetric catalysis including bifunctional catalysis, cooperative catalysis, multimetallic catalysis, and novel tandem reactions • Has applications for pharmaceuticals, agrochemicals, materials, and flavour and fragrance

Enantioselective Chemical Synthesis
Enantioselective Chemical Synthesis

Author: Elias J. Corey

Publisher: Elsevier

Published: 2013-10-23

Total Pages: 334

ISBN-13: 0128001518

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Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages