Effect of Resveratrol and Implant Surface Topography on Osseointegration Under Hyperglycemic Conditions

Effect of Resveratrol and Implant Surface Topography on Osseointegration Under Hyperglycemic Conditions

Author: Anthony Joseph Staibano

Publisher:

Published: 2021

Total Pages: 0

ISBN-13:

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Chronic hyperglycemia compromises bone structure and may contribute to dental implant failures. Previous studies show that topographically complex implant surfaces enhance bone-implant anchorage compromised by hyperglycemia. Furthermore, resveratrol (RSV) is a potent antioxidant that counteracts the effects of hyperglycemia. The influence of two implant surface profiles (micro- and nanotopographically complex) and RSV administration on osseointegration in hyperglycemic bone was investigated. 240 custom-designed threaded implants were inserted in the proximal tibiae of 120 hyperglycemic Wistar rats. Rats were randomized to receiving weekly subcutaneous resveratrol or propylene glycol injections for a maximum of 4 weeks. Implants then underwent reverse-torque mechanical testing at timepoints between 5 and 84 days. Nanotopographic implants significantly enhanced bone-implant anchorage during implant osseointegration, which transpires within 28 days post-implantation, while resveratrol significantly increased bone-implant anchorage at 84 days, indicating an effect on bone remodelling. This likely occurred due to an influence of RSV on tibial longitudinal growth.


Bone Response to Dental Implant Materials

Bone Response to Dental Implant Materials

Author: Adriano Piattelli

Publisher: Woodhead Publishing

Published: 2016-10-27

Total Pages: 286

ISBN-13: 0081002882

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Bone Response to Dental Implant Materials examines the oral environment and the challenges associated with dental biomaterials. Understanding different in vivo and in vitro responses is essential for engineers to successfully design and tailor implant materials which will withstand the different challenges of this unique environment. This comprehensive book reviews the fundamentals of bone responses in a variety of implant materials and presents strategies to tailor and control them. - Presents a specific focus on the development and use of biomaterials in the oral environment - Discusses the basic science of the dental interface and its clinical applications - Contains important coverage on the monitoring and analysis of the dental implant interface


Implant Surfaces and their Biological and Clinical Impact

Implant Surfaces and their Biological and Clinical Impact

Author: Ann Wennerberg

Publisher: Springer

Published: 2015-01-05

Total Pages: 190

ISBN-13: 3662453797

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This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients.


Bio-Implant Interface

Bio-Implant Interface

Author: J.E. Ellingsen

Publisher: CRC Press

Published: 2003-04-29

Total Pages: 467

ISBN-13: 0203491432

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Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning


Tissue-integrated Prostheses

Tissue-integrated Prostheses

Author: Per-Ingvar Brånemark

Publisher: Quintessence Publishing (IL)

Published: 1985

Total Pages: 360

ISBN-13:

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" This book provides the prosthodontist and oral surgeon for the first time with a safe, predictable, and scientifically proven method for permanently anchoring artificial tooth abutments in the jawbones. It combines the osseointegration research results of biologists, physicists, bioengineers, oral surgeons, and prosthodontists to demonstrate step-by-step how to achieve long-term osseointegration of dental implants" -- Amazon.


Bio-Implant Interface

Bio-Implant Interface

Author: J.E. Ellingsen

Publisher: CRC Press

Published: 2003-04-29

Total Pages: 593

ISBN-13: 1135508216

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Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning


Effect of High Insertion Torque on the Coronal Surface Roughness of Implants with Different Macro-geometries. An In- Vitro Study

Effect of High Insertion Torque on the Coronal Surface Roughness of Implants with Different Macro-geometries. An In- Vitro Study

Author: zeev ormianer

Publisher:

Published: 2017

Total Pages:

ISBN-13:

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Background. Numerous studies are dealing with implants placement using different torque degrees. Most of them studied the effect of the torque values on the tissues both the bone and the soft tissue housing the implants in short and long term. Too little is described what is the effect of the friction created between the implant's high insertion torque and the bone, on the average roughness of the implant surface as supplied by the manufacturer. Aim.This study aimed to evaluate the effect of different osteotomy diameters on the coronal surface roughness of standard implants, which is thought to be an important factor among others, for successful osseointegration.Materials and Methods. 100 coronally shaped micro u2013threads (NEO 3.75 mm, Alpha- Biou00ae) and 100 coronally shaped microu2013ring implants (SPI 3.75 mm Alpha- Biou00ae) were examined. Each group was divided into 4 groups of 25 implants. Sub- groups 1, 2 and 3 were inserted into bone analogs (Bone-simu00ae) with prepared decreasing osteotomies diameters of 3.65, 3.2 and 2.8 mm respectively. The insertion torque and temperature during the installation of the implant into the different diameters were monitored. Group 4, composed of implants taken from the original packages and subjected to surface roughness measurements served as control and a reference value for the inserted implants . Surface topography of the coronal surfaces of each implant of test groups was scanned using Nanofocus u03bcsurf explorer (Nanofocusu00ae) , and values were compared to the control group roughness. Results.For both groups highest insertion torque and temperature values were measured during implants insertion into 2.8 mm osteotomies (NEO: 243.26u00b136.77Ncm, 44.82u00bau00b114.34u00ba ; SPI: 239.10u00b129.50[Ncm] , 38.86u00bau00b17.52u00ba), (p


Treatments to Optimize Dental Implant Surface Topography and Enhance Cell Bioactivity

Treatments to Optimize Dental Implant Surface Topography and Enhance Cell Bioactivity

Author: Jaume Miranda-Rius

Publisher:

Published: 2016

Total Pages:

ISBN-13:

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Osseointegration is a biological process in which histological, surgical, infectious factors, biomechanical load, and the choice of biomaterials all play important roles. In the case of dental implants, the success of this process is also influenced by the design, composition, and properties of the implant surface, which may stimulate cell bioactivity and promote osteoblast adhesion. Currently, the raw materials most frequently used in the manufacture of dental implants are titanium, its alloys, and certain ceramic materials such as zirconia. Multiple macroscopic designs incorporating various diameters, lengths, shapes, and types of screw offer different options for specific clinical situations. The characteristics of implant surfaces have aroused great interest, due to their importance in osseointegration. The different methods used to modify surface properties are classified as additive (id est, impregnation and coating) or subtractive (id est, physical, mechanical and chemical methods). The surface characteristics of dental implants also have a significant influence on peri-implant microbiota.