Both macro- and microeconomic aspects of biotechnology are discussed in this book for biologists studying microbiology, biochemistry and genetics. It explains economics and accounting procedures from first principles and assumes no prior knowledge of these areas. The author works on developing new biotechnological projects. He draws extensively on his own experience and brings together the factors which determine commercial reasoning towards biotechnology in areas such as markets, project selection, costing and capital investment. His subjects include market analysis, fermentation, enzyme technology, genetic engineering and many others; they are all tied together by a common framework of industrial and technological development.
The principal message of this book is that thermodynamics and statistical mechanics will benefit from replacing the unfortunate, misleading and mysterious term "entropy" with a more familiar, meaningful and appropriate term such as information, missing information or uncertainty. This replacement would facilitate the interpretation of the "driving force" of many processes in terms of informational changes and dispel the mystery that has always enshrouded entropy. It has been 140 years since Clausius coined the term "entropy"; almost 50 years since Shannon developed the mathematical theory of "information"--Subsequently renamed "entropy." In this book, the author advocates replacing "entropy" by "information," a term that has become widely used in many branches of science. The author also takes a new and bold approach to thermodynamics and statistical mechanics. Information is used not only as a tool for predicting distributions but as the fundamental cornerstone concept of thermodynamics, held until now by the term "entropy." The topics covered include the fundamentals of probability and information theory; the general concept of information as well as the particular concept of information as applied in thermodynamics; the re-derivation of the Sackur-Tetrode equation for the entropy of an ideal gas from purely informational arguments; the fundamental formalism of statistical mechanics; and many examples of simple processes the "driving force" for which is analyzed in terms of information.
The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.
Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.
Biotechnology can bring major breakthroughs in agriculture. The book examines the experience of introduction of biotechnology in Indian agriculture, specifically, examining the performance of Bt cotton versus non-Bt cotton across India’s major cotton states, namely Andhra Pradesh, Gujarat, Maharashtra and Tamil Nadu, which together account for nearly 70 percent of the country’s cotton production. Major advances in biotechnology have made it possible to directly identify genes, determine their functions, and transfer them from one organism to another. The advances have spawned many technologies and Bt cotton is one important outcome. Bt cotton has become one of the most widely cultivated transgenic crops and is currently grown in 21 countries - 11 developing and 10 industrialized countries. The Government of India was relatively late in permitting biotechnology, only approving the cultivation of three transgenic Bt cotton hybrids from April 2002. Many concerns were raised about their performance there was strong opposition from some quarters. In India, Gujarat and Maharastra were the first states to adopt them, followed by Andhra Pradesh, Karnataka, Tamil Nadu and Madhya Pradesh. Based on a sample of 694 farming households, the book examines and analyzes the performance on the yields, pesticide costs, seed costs, overall production costs and profits. It also reports on the environmental impacts, satisfaction with the technology and ways of improving its performance.
Using economic models and empirical analysis, this volume examines a wide range of agricultural and biofuel policy issues and their effects on American agricultural and related agrarian insurance markets. Beginning with a look at the distribution of funds by insurance programs—created to support farmers but often benefiting crop processors instead—the book then examines the demand for biofuel and the effects of biofuel policies on agricultural price uncertainty. Also discussed are genetically engineered crops, which are assuming an increasingly important role in arbitrating tensions between energy production, environmental protection, and the global food supply. Other contributions discuss the major effects of genetic engineering on worldwide food markets. By addressing some of the most challenging topics at the intersection of agriculture and biotechnology, this volume informs crucial debates.
Around the world, many countries are increasing efforts to promote biomass production for industrial uses including biofuels and bio-products such as chemicals and bio-plastic. Against a backdrop of lively public debate on sustainability, bioenergy wields both positive and negative impacts upon a variety of environmental and socio-economic issues. These include property rights, labor conditions, social welfare, economic wealth, poverty reduction and more. This book discusses the issues and impacts of bioenergy, taking into account the local and regional framework under which bioenergy is produced, touching upon educational level, cultural aspects, the history and economies of the producing countries and an array of policies including environmental and social targets. The book surveys and analyzes global bioenergy production from a number of perspectives. The authors illustrate the complexity of interrelated topics in the bioenergy value chain, ranging from agriculture to conversion processes, as well as from social implications to environmental effects. It goes on to offer insight on future challenges associated with the expected boom of a global bio-based economy, which contributes to the paradigm shift from a fossil-based to a biomass and renewable energy-based economy. The expert contributors include researchers, investors, policy makers, representatives from NGOs and other stakeholders, from Europe, Africa, Asia and Latin America. Their contributions build upon the results of the Global-Bio-Pact project on “Global Assessment of Biomass and Bio-product Impacts on Socio-economics and Sustainability,” which was supported by the European Commission in its 7th Framework Program for Research and Technological Development, conducted from February 2010 to January 2013. The book benefits policy makers, scientists and NGO staffers working in the fields of agriculture, forestry, biotechnology and energy.
This book includes 6 chapters examining the relevance of transgenic crops in food production, prices and the environment. It initially describes the historical evolution of biotechnology and defines key terms, before moving on to explore transgenic technology and food regime concepts. It analyses genetically modified organism (GMO) policy as part of overall agrarian policy, considering neoregulation in the USA, the EU, Brazil, Russia, China, India, South Africa and Serbia, as well as discussing agricultural performance, support and trade relations. The effect of transgenic food production on world food prices is also examined, along with food security at global and regional levels, and the links between GMOs and world hunger. The environmental implications of transgenic technology are considered through analysis of pesticide and fertilizer usage and efficiency, and pesticide consumption in GMO and non-GMO producing countries. Finally, the book considers the entry of transgenic ingredients into the food chain and lists GMOs approved for use in foods and products contaminated with unapproved GMOs. The key features of this book include: a detailed analysis of economic data; a comparison of international trends, including BRICS countries (Brazil, Russia, India, China and South Africa) and Serbia; evaluation of environmental and food security implications; and glossary of important terms. This book is intended for a wide range of professionals and researchers whose interests relate to all aspects of the global food system, including policy makers, policy advisers and analysts, NGOs, students and other interest groups.
Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.
Early integration is the key to success in industrial biotechnology. This is as true when a selected wild-type organism is put to work as when an organism is engineered for a purpose. The present volume Engineering and Manufacturing for Biotechnology took advantage of the 9th European Congress on Biotechnology (Brussels, Belgium, July 11-15, 1999): in the topics handled and in the expertise of the contributors, the engineering science symposia of this congress offered just what was needed to cover the important topic of integration of process engineering and biological research. The editors have solicited a number of outstanding contributions to illustrate the intimate interaction between productive organisms and the numerous processing steps running from the initial inoculation to the packaged product. Upstream processing of the feed streams, selection of medium components, product harvesting, downstream processing, and product conditioning are just a few major steps. Each step imposes a number of important choices. Every choice is to be balanced against time to market, profitability, safety, and ecology.
